3-Aminobenzamide is a

benzamide Benzamide is a organic compound with the chemical formula of C6H5C(O)NH2. It is the simplest amide derivative of benzoic acid Benzoic acid is a white (or colorless) solid organic compound with the formula , whose structure consists of a benz ...

. It is an off-white powder and has the chemical formula C₇H₈N₂O.

Preparation

3-Aminobenzamide can be prepared through the reduction of 3-nitrobenzamide by catalytic hydrogenation.

Uses

3-Aminobenzamide is an inhibitor of

poly ADP ribose polymerase Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. Members of PARP family The PARP family comprises 17 members (10 putative) ...

(PARP), an enzyme responsible for

DNA repair DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA dam ...

, transcription control, and

programmed cell death Programmed cell death (PCD; sometimes referred to as cellular suicide) is the death of a cell as a result of events inside of a cell, such as apoptosis or autophagy. PCD is carried out in a biological process, which usually confers advantage durin ...

. When PARP is activated it rapidly uses up stores of

nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism. Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an aden ...

(NAD) in the cell as it performs DNA repair. Low levels of NAD deplete the amount of ATP found in the cell which can lead to cell death. The structure of 3-aminobenzamide is similar to that of NAD so it binds to PARP and prevents it from using up NAD. PARP is often a target of cancer therapy and so 3-aminobenzamide could potentially be used as an anticancer drug.

References

{{DEFAULTSORT:Aminobenzamide, 3- Benzamides Amines