2C-T-7 is a
psychedelic
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of ...
phenethylamine
Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace amin ...
of the
2C family. In his book ''
PiHKAL: A Chemical Love Story'',
Alexander Shulgin
Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author. He is credited with introducing 3,4-methylenedioxymethamph ...
lists the dosage range as 10 to 30
mg. 2C-T-7 is generally taken
orally, and produces
psychedelic
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of ...
and
entactogenic effects that last 8 to 15 hours. Up until
Operation Web Tryp Operation Web Tryp was a United States Drug Enforcement Administration operation that ended on July 21, 2004 with the arrests of 10 persons. Its purpose was to investigate web sites suspected of distribution of unscheduled, unregulated tryptamines ...
and three deaths, two of which involved the use of other drugs in addition to 2C-T-7, and one which involved an excessive insufflated dose, 2C-T-7 was sold commercially in Dutch and Japanese
smartshop
A smart shop (or smartshop) is a retail establishment that specializes in the sale of psychoactive substances, usually including psychedelics, as well as related literature and paraphernalia. The name derives from the name " smart drugs", a clas ...
s and online. It is known on the streets as Blue Mystic or 7th Heaven. There has been little real research done on this chemical other than Shulgin's comments in PiHKAL and a few small animal studies mostly aimed at detecting metabolites.
Pharmacology
The mechanism that produces the psychedelic and entactogenic effects of 2C-T-7 is most likely to result from action as a
5-HT2A serotonin receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neur ...
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
in the brain, a mechanism of action shared by most currently-known hallucinogenic tryptamines and phenethylamines.
Effects
2C-T-7 is psychedelic. In ''PiHKAL'', Shulgin records that the hallucinations are unique, and that the chemical may cause muscle tension and an altered vocal quality.
Deaths
The
Partnership for a Drug-Free America
Partnership to End Addiction, first known as the Partnership for a Drug-Free America (PDFA) then later as the Partnership at DrugFree.org, and The Partnership for Drug-Free Kids, is a New York, New York, New York City-based nonprofit, non-profit ...
reports that 2C-T-7 can be lethal even in small doses; however, they provide no source for their claim and of the three known deaths of 2C-T-7 intoxicated individuals, all involved either excessive
insufflated doses or the concomitant ingestion of other stimulants such as ephedrine and MDMA. There have been at least three reported deaths related to 2C-T-7 use as of August 2007, mainly at insufflated doses of 30 mg or more or combined with stimulants such as
MDMA
3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in Tablet (pharmacy), tablet form (ecstasy) and crystal form (molly or mandy), is a potent empathogen–entactogen with stimulant properties primarily used for Recreational dru ...
, as well as a number of very uncomfortably intense effects and hospitalizations, these mostly followed insufflation of 2C-T-7. In January 2002, ''
Rolling Stone
''Rolling Stone'' is an American monthly magazine that focuses on music, politics, and popular culture. It was founded in San Francisco, San Francisco, California, in 1967 by Jann Wenner, and the music critic Ralph J. Gleason. It was first kno ...
'' published an article about 2C-T-7 entitled "The New (legal) Killer Drug", although the legal status of the drug was misrepresented in the article, as 2C-T-7 may have been already illegal under the United States' legally ambiguous analog act. A detailed response on the website Disinformation challenged the accuracy of much of the reporting in that ''Rolling Stone'' article.
All of these known deaths of individuals under the influence of 2C-T-7, therefore, occurred in those known either to be intoxicated with potentially deadly stimulants such as
ephedrine
Ephedrine is a central nervous system (CNS) stimulant that is often used to prevent low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment. It is of unclear benefit in ...
or
MDMA
3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in Tablet (pharmacy), tablet form (ecstasy) and crystal form (molly or mandy), is a potent empathogen–entactogen with stimulant properties primarily used for Recreational dru ...
or after the individual insufflated an excessive amount of 2C-T-7—excessive being an amount greater than necessary to induce the full range of the drug's effects, such as the reported 35 mg insufflated dose taken by the individual who died in the fall of 2000. This reported dose was characterized as "excessive" by the US DEA.
Legal status
Around the year 2000, 2C-T-7 began to change from an obscure chemical to a drug used at parties and clubs in North America and Europe as it became available through a number of grey-market commercial vendors. This aroused the attention of the authorities, and many countries have since scheduled the chemical.
Germany
2C-T-7 is scheduled in Germany. (BTMG)
Australia
In Australia,
2C-T-2 and 2C-T-7 are covered by the country's
analogue drug laws.
Canada
As of October 31, 2016, 2C-T-7 is a controlled substance (Schedule III) in Canada.
China
As of October 2015 2C-T-7 is a controlled substance in China.
The Netherlands
The Netherlands was the first country in the world to ban 2C-T-7, after being sold in smartshops for a short period. After 2C-T-2 was first banned, 2C-T-7 quickly appeared on the market, but was soon banned as well. 2C-T-7 is a list I drug of the
Opium Law
The Opium Law (or ''Opiumwet'' in Dutch) is the section of the Dutch law which covers nearly all psychotropic drugs.
Origin and history
In 1912, the First International Opium Conference took place in The Hague, where agreements were made abou ...
.
Sweden
Schedule I in Sweden. 2C-T-7 was first classified as "health hazard" under the act
''Lagen om förbud mot vissa hälsofarliga varor'' (translated ''Act on the Prohibition of Certain Goods Dangerous to Health'') as of April 1, 1999, under SFS 1999:58 that made it illegal to sell or possess.
United Kingdom
In 1999,
Alexander Shulgin
Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author. He is credited with introducing 3,4-methylenedioxymethamph ...
was sent a copy of a letter from the
British Home Office to several of its administrative associates that in effect placed all compounds listed in
PiHKAL into Class A.
United States
On September 20, 2002, 2C-T-7 was classified as a
Schedule I substance in the United States by an emergency ruling by the
DEA
The Drug Enforcement Administration (DEA; ) is a United States federal law enforcement agency under the U.S. Department of Justice tasked with combating drug trafficking and distribution within the U.S. It is the lead agency for domestic en ...
. On March 18, 2004, the DEA published a Final Rule in the Federal Register permanently placing 2C-T-7 in Schedule I. (69 FR 12794).
Notes
External links
Erowid 2C-T-7 VaultPiHKAL #43 2C-T-7by
Alexander Shulgin
Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author. He is credited with introducing 3,4-methylenedioxymethamph ...
2C-T-7 Entry in PiHKAL
{{Serotonergics
2C (psychedelics)
Designer drugs
Thioethers