The
enzyme 2-dehydro-3-deoxyglucarate aldolase ()
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:2-dehydro-3-deoxy-
D-glucarate
pyruvate + tartronate semialdehyde
This enzyme belongs to the family of
lyase
In biochemistry, a lyase is an enzyme that catalyzes the breaking (an elimination reaction) of various chemical bonds by means other than hydrolysis (a substitution reaction) and oxidation, often forming a new double bond or a new ring structure. ...
s, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The
systematic name of this enzyme class is 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming). Other names in common use include 2-keto-3-deoxyglucarate aldolase, alpha-keto-beta-deoxy-D-glucarate aldolase, and 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase. This enzyme participates in
ascorbate and aldarate metabolism.
Structural studies
As of late 2007, 6
structures have been solved for this class of enzymes, with
PDB accession codes , , , , , and .
References
*
EC 4.1.2
Enzymes of known structure
{{4.1-enzyme-stub