2-Tetralone is an

organic chemical compound In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon chemical bond, bonds. Due to carbon's ability to Catenation, catenate (form chains with other carbon atoms), millions of organic c ...

with the molecular formula C₁₀H₁₀O. This colourless oil is an intermediate in organic synthesis. It is a ketone derivative of

tetralin Tetralin (1,2,3,4-tetrahydronaphthalene) is a hydrocarbon having the chemical formula C10H12. It is a partially hydrogenated derivative of naphthalene. It is a colorless liquid that is used as a hydrogen-donor solvent. Production Tetralin is pro ...

, a

hydrogenate Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a catalyst such as nickel, palladium or platinum. The process is commonly employed to reduce or saturate organic ...

d derivative of naphthalene. A related compound is

1-tetralone 1-Tetralone is a bicyclic aromatic hydrocarbon and a ketone. In terms of its structure, it can also be regarded as benzo-fused cyclohexanone. It is a colorless oil with a faint odor. It is used as starting material for agricultural and pharmace ...

. 2-Tetralone is prepared by reductive cleavage of 2-naphthyl ethers.

Applications

2-Tetralone is an intermediate in the synthesis of a variety of pharmaceutical drugs including

L-687,384 L-687,384 is a sigma receptor agonist, selective for the σ1 subtype, as well as an NMDA antagonist NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor ( N ...

nepinalone Nepinalone is a cough suppressant. Its brand names include Placatus, Tussolvina, and Nepitus. The effect is evident after 20–30 minutes after administration and persists for at least 4 hours. It acts primarily at the level of the CNS, but also ...

, napamezole,

spirodone R-4066 (Spirodone) is a drug which is an analogue of the opioid analgesic methadone, or more accurately norpipanone, where the metabolically labile dimethylamino group has been replaced by a piperidinospiro group. Developed by Janssen Pharmaceu ...

, and

trioxifene Trioxifene ( INN) (developmental code name LY-133,314), or as the salt trioxifene mesylate (USAN), is a selective estrogen receptor modulator (SERM) with competitive binding activity against estradiol for the ERα and antagonistic activity aga ...

References

{{DEFAULTSORT:Tetralone, 2- Aromatic ketones Tetralins