(–)-2-Methoxyethyl-18-methoxycoronaridinate (ME-18-MC) is a second generation synthetic derivative of
ibogaine developed by the research team led by the pharmacologist
Stanley D. Glick
Stanley may refer to:
Arts and entertainment
Film and television
* ''Stanley'' (1972 film), an American horror film
* ''Stanley'' (1984 film), an Australian comedy
* ''Stanley'' (1999 film), an animated short
* ''Stanley'' (1956 TV series) ...
from the
Albany Medical College and the chemist
Martin E. Kuehne Martin may refer to:
Places
* Martin City (disambiguation)
* Martin County (disambiguation)
* Martin Township (disambiguation)
Antarctica
* Martin Peninsula, Marie Byrd Land
* Port Martin, Adelie Land
* Point Martin, South Orkney Islands
Aus ...
from the
University of Vermont. In animal studies it has shown similar efficacy to the related compound
18-methoxycoronaridine
18-Methoxycoronaridine (18-MC, or MM-110) is a derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley D. Glick from the Albany Medical College and the chemists
Upul K. Bandarage and Martin E. Kuehne fro ...
(18-MC) at reducing self-administration of
morphine and
methamphetamine
Methamphetamine (contracted from ) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamph ...
but with higher potency by weight, showing anti-addictive effects at the equivalent of half the minimum effective dose of 18-MC. Similarly to 18-MC itself, ME-18-MC acts primarily as a selective
α3β4 nicotinic acetylcholine antagonist, although it has a slightly stronger effect than 18-MC as an
NMDA antagonist, and its effects on
opioid receptors are weaker than those of 18-MC at all except the
kappa opioid receptor, at which it has slightly higher affinity than 18-MC.
See also
*
18-Methylaminocoronaridine
(–)-18-Methylaminocoronaridine (18-MAC) is a second generation synthetic derivative of ibogaine developed by the research team led by the pharmacologist Stanley D. Glick from the Albany Medical College and the chemist Martin E. Kuehne from th ...
*
18-Methoxycoronaridine
18-Methoxycoronaridine (18-MC, or MM-110) is a derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley D. Glick from the Albany Medical College and the chemists
Upul K. Bandarage and Martin E. Kuehne fro ...
*
Coronaridine
*
Ibogaine
*
Noribogaine
Noribogaine (actually O-desmethylibogaine), or 12-hydroxyibogamine, is the principal psychoactive metabolite of the oneirogen ibogaine. It is thought to be involved in the antiaddictive effects of ibogaine-containing plant extracts, such as '' ...
*
Voacangine
References
{{DEFAULTSORT:Methoxyethyl-18-Methoxycoronaridinate, 2-
Drug rehabilitation
Iboga
Nicotinic antagonists