2-Bromomescaline (2-Br-M) is a
derivative
In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. ...
of the
phenethylamine hallucinogen
Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorize ...
mescaline which has an unusual 2-bromo substitution. It is an
agonist for
serotonin receptors, with a
binding affinity
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a m ...
of 215 nM at
5-HT1A, 513 nM at
5-HT2A and 379 nM at
5-HT2C, so while it is around ten times more tightly binding than mescaline at 5-HT
1A and 5-HT
2A receptors, it is over twenty times more potent at 5-HT
2C.
See also
*
6-Bromo-MDA
2-Bromo-4,5-methylenedioxyamphetamine (6-Bromo-MDA) is a lesser-known psychedelic drug and a substituted amphetamine. It was first synthesized by Alexander Shulgin. In his book '' PiHKAL'', the dose is listed as 350 mg and the duration unkn ...
*
6-Chloro-MDMA
6-Chloro-MDMA (6-Cl-MDMA, 2-Cl-4,5-MDMA) is a derivative of the amphetamine drug MDMA, which has been identified both in seized "ecstasy" tablets and in urine samples from drug users. It is thought most likely to be an impurity from synthesis and ...
References
Bromoarenes
Psychedelic phenethylamines
Serotonin receptor agonists
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