1V-LSD or 1-valeryl-D-lysergic acid diethylamide is a psychotropic substance and a

research chemical Research chemicals are chemical substances used by scientists for medical and scientific research purposes. One characteristic of a research chemical is that it is for laboratory research use only; a research chemical is not intended for human o ...

with

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of ...

effects. 1V-LSD is an artificial derivative of natural

lysergic acid Lysergic acid, also known as -lysergic acid and (+)-lysergic acid, is a precursor for a wide range of ergoline alkaloids that are produced by the ergot fungus and found in the seeds of '' Turbina corymbosa'' (ololiuhqui), '' Argyreia nervosa'' ...

, which occurs in ergot alkaloids, as well as being an analogue of LSD. 1V-LSD has been sold online since a recent amendment to the German NpSG was enforced which controls 1P-LSD and now 1cP-LSD and several other lysergamides.

Pharmacology

As demonstrated with other N-acylated derivatives of LSD, 1V-LSD is believed to serve as a prodrug for LSD but may also act as a weak partial agonist at the

5-HT2A receptor The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). The 5-HT2A receptor is a cell surface receptor, but has several intracellular locations. 5-HT is s ...

Animal studies

A Head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and

1cP-LSD 1cP-LSD (''N''1-(cyclopropylmethanoyl)-lysergic acid diethylamide) is an acylated derivative of lysergic acid diethylamide (LSD), which has been sold as a designer drug. In tests on mice it was found to be an active psychedelic with similar pote ...

, with behavioral effects also closely resembling these

structural analogs A structural analog (analogue in modern traditional English; Commonwealth English), also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a ce ...

Chemistry

1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety.

Ehrlich's reagent Ehrlich's reagent or Ehrlich reagent is a reagent containing ''p''-dimethylaminobenzaldehyde (DMAB) and thus can act as an indicator to presumptively identify indoles and urobilinogen. Several Ehrlich tests use the reagent in a medical test; som ...

is used to identify the presence of an indole

moiety Moiety may refer to: Chemistry * Moiety (chemistry), a part or functional group of a molecule ** Moiety conservation, conservation of a subgroup in a chemical species Anthropology * Moiety (kinship), either of two groups into which a society is ...

; the chemical backbone of the lysergamide and ergoline molecules. However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh.

Legal position

Since 1V-LSD is relatively new to the market, it is still uncontrolled in most countries. Specifically, 1V-LSD is not controlled in Germany since it does not fulfil all the requirements for legislation under section 5.2 of the NpSG. The substance has neither been recorded in the German BtMG. Since March 2nd 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled. 1v-LSD strip blotters

References

Designer drugs Psychedelic_drugs Lysergamides Lysergic acid diethylamide Prodrugs Serotonin receptor agonists {{hallucinogen-stub

Pharmacology

Animal studies

Chemistry

Legal position

See also

References