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Between 1738 and 1739, a
smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) c ...
epidemic An epidemic (from Ancient Greek, Greek ἐπί ''epi'' "upon or above" and δῆμος ''demos'' "people") is the rapid spread of disease to a large number of patients among a given population within an area in a short period of time. Epidemics ...
broke out among the
Cherokee The Cherokee (; chr, ᎠᏂᏴᏫᏯᎢ, translit=Aniyvwiyaʔi or Anigiduwagi, or chr, ᏣᎳᎩ, links=no, translit=Tsalagi) are one of the indigenous peoples of the Southeastern Woodlands of the United States. Prior to the 18th century, t ...
who resided in the
Province of North Carolina Province of North Carolina was a province of Kingdom of Great Britain, Great Britain that existed in North America from 1712(p. 80) to 1776. It was one of the five Southern Colonies, Southern colonies and one of the Thirteen Colonies, thir ...
, as well as in the
Province of South Carolina Province of South Carolina, originally known as Clarendon Province, was a province of Great Britain that existed in North America from 1712 to 1776. It was one of the five Southern colonies and one of the thirteen American colonies. The monar ...
. The epidemic was most damaging in
Eastern North Carolina Eastern North Carolina (sometimes abbreviated as ENC) is the region encompassing the eastern tier of North Carolina. It is known geographically as the state's Coastal Plain region. Primary subregions of Eastern North Carolina include the Sandhil ...
. The epidemic decimated the Cherokee and Catawba peoples, causing the deaths of about half of each tribe's population. Many other Native tribes were decimated as well. Smaller numbers of
European European, or Europeans, or Europeneans, may refer to: In general * ''European'', an adjective referring to something of, from, or related to Europe ** Ethnic groups in Europe ** Demographics of Europe ** European cuisine, the cuisines of Europe ...
settlers and Africans also died during the epidemic. The depopulation after the epidemic caused the Cherokee to abandon many villages, particularly in
Georgia Georgia most commonly refers to: * Georgia (country), a country in the Caucasus region of Eurasia * Georgia (U.S. state), a state in the Southeast United States Georgia may also refer to: Places Historical states and entities * Related to the ...
along the Chattooga,
Tugaloo Tugaloo (''Dugiluyi'' (ᏚᎩᎷᏱ)) was a Cherokee town located on the Tugaloo River, at the mouth of Toccoa Creek. It was south of Toccoa and Travelers Rest State Historic Site in present-day Stephens County, Georgia. Cultures of ancient ind ...
, and
Chattahoochee The Chattahoochee River forms the southern half of the Alabama and Georgia (U.S. state), Georgia border, as well as a portion of the Florida - Georgia border. It is a tributary of the Apalachicola River, a relatively short river formed by the con ...
rivers. The Cherokee did not begin to recover from their population loss until the end of the 18th century. An estimated 7,700–11,700 died during the epidemic. The 1738–1739 epidemic was the first known occasion where doctors utilized widespread inoculation as a smallpox preventative. The epidemic was first brought to
Charleston, South Carolina Charleston is the largest city in the U.S. state of South Carolina, the county seat of Charleston County, and the principal city in the Charleston–North Charleston metropolitan area. The city lies just south of the geographical midpoint o ...
by sea. From there, the epidemic spread throughout North and South Carolina. James Kilpatrick was the main person responsible for inoculations in Charleston, inoculating between 800 and 1,000 people, of whom only eight died. The Irish-born historian
James Adair James Adair may refer to: * James Makittrick Adair (1728–1802), Scottish doctor practising in Antigua *James Adair (historian) (1709–1783), Irish historian of the American Indians * James Adair (serjeant-at-law) (c. 1743–1798), English Whig M ...
claimed that smallpox was introduced by " Guinea-men", enslaved people from West Africa. The epidemic was probably spread to the Cherokee by white traders in the summer of 1739. The virus may also have come from
Spanish Florida Spanish Florida ( es, La Florida) was the first major European land claim and attempted settlement in North America during the European Age of Discovery. ''La Florida'' formed part of the Captaincy General of Cuba, the Viceroyalty of New Spain, ...
. 900 Cherokees had joined the British to fight the Spanish in Florida in 1739, and may have brought smallpox back with them. Cherokee "religious physicians" blamed the plague on "adulterous intercourse" among young married people, while Cherokee chiefs alleged that their people had been poisoned by infected rum brought by white traders. Thousands of Cherokee died from the epidemic. It was reported that upon seeing themselves become infected and disfigured, some Cherokee resorted to
suicide Suicide is the act of intentionally causing one's own death. Mental disorders (including depression, bipolar disorder, schizophrenia, personality disorders, anxiety disorders), physical disorders (such as chronic fatigue syndrome), and s ...
. Adair claimed that Cherokee people shot themselves, cut their own throats, stabbed themselves with knives or sharp-pointed canes, or burned themselves alive. Cherokee healers attempted to use traditional medicine against the epidemic. Cherokee healers would "sweat" their patients and then dunk them into a cold river, but many Cherokee died from the shock. This caused some of the Cherokee healers to abandon their spiritual beliefs in despair. As the Cherokee began to abandon traditional spiritual beliefs because of their ineffectiveness against smallpox, this left an opening for Christian missionaries who were working to proselytize among the Cherokee. The epidemic was so damaging to the
Waxhaw people The Waxhaw people (also referred to as Wisacky, the Gueça and possibly Wastana and Weesock) were a tribe native to what are now the counties of Lancaster, in South Carolina; and Union and Mecklenburg in North Carolina, around the area of presen ...
that they abandoned their historic homelands in 1740 that were located in what is now
Union County, North Carolina Union County is a county located in the U.S. state of North Carolina. As of the 2020 census, the population was 238,267. Its county seat is Monroe. Union County is included in the Charlotte-Concord- Gastonia, NC- SC Metropolitan Statistical Ar ...
. The remnants of the Waxhaw people joined with the
Catawba Catawba may refer to: *Catawba people, a Native American tribe in the Carolinas *Catawba language, a language in the Catawban languages family *Catawban languages Botany *Catalpa, a genus of trees, based on the name used by the Catawba and other N ...
. The lands of the Waxhaw were subsequently occupied by English, German, Scottish, and Welsh settlers.


References

{{DEFAULTSORT:1738-1739 North Carolina smallpox epidemic 1738 disease outbreaks 1739 disease outbreaks 1738 in North Carolina 1739 in North Carolina Catawba Province of Georgia Colonial South Carolina 18th century Cherokee history Province of North-Carolina Smallpox in the United States Disease outbreaks in the United States Disasters in North Carolina