16-Methylene-17α-hydroxyprogesterone acetate is a
progestin of the
17α-hydroxyprogesterone
17α-Hydroxyprogesterone (17α-OHP), also known as 17-OH progesterone (17-OHP), or hydroxyprogesterone (OHP), is an endogenous progestogen steroid hormone related to progesterone. It is also a chemical intermediate in the biosynthesis of many o ...
group which was never marketed.
Given
orally, it shows about 2.5-fold the
progestogenic activity of
parenteral
A route of administration in pharmacology and toxicology is the way by which a drug, fluid, poison, or other substance is taken into the body.
Routes of administration are generally classified by the location at which the substance is applied. ...
progesterone in animal
bioassay
A bioassay is an analytical method to determine the concentration or potency of a substance by its effect on living animals or plants (''in vivo''), or on living cells or tissues(''in vitro''). A bioassay can be either quantal or quantitative, dir ...
s.
It is a
parent compound
In chemistry, a parent structure is the structure of an unadorned ion or molecule from which derivatives can be visualized. Parent structures underpin systematic nomenclature and facilitate classification. Fundamental parent structures have on ...
of the following clinically used progestins:
*
Chlormethenmadinone acetate (6-chloro-16-methylene-17α-hydroxy-Δ
6-progesterone acetate)
*
Melengestrol acetate (6-methyl-16-methylene-17α-hydroxy-Δ
6-progesterone acetate)
*
Methenmadinone acetate (16-methylene-17α-hydroxy-Δ
6-progesterone acetate)
*
Segesterone acetate
Segesterone acetate (SGA), sold under the brand names Nestorone, Elcometrine, and Annovera, is a progestin medication which is used in birth control and in the treatment of endometriosis in the United States, Brazil, and other South American coun ...
(16-methylene-17α-hydroxy-19-norprogesterone acetate)
References
Abandoned drugs
Acetate esters
Diketones
Pregnanes
Progestogens
Vinylidene compounds
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