100 Proof may refer to:
* 100° proof,
alcohol proof
*
''100 Proof'' (film), 1997 film
*
''100 Proof'' (album), Kellie Pickler album
* ''
100 Proof: The Hangover'', Statik Selektah album
*
"100 Proof" (song), Kellie Pickler song
*
100 Proof (Aged in Soul), an American funk/soul group
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