1-Hydroxyphenanthrene is a
phenanthrol and a human metabolite of
phenanthrene
Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) with formula C14H10, consisting of three fused benzene rings. It is a colorless, crystal-like solid, but can also appear yellow. Phenanthrene is used to make dyes, plastics and pesticides, e ...
that can be detected in urine of persons exposed to PAHs.
It can also be used as a marker for PAH pollution measured in marine fish bile.
The model fungus ''
Cunninghamella elegans
''Cunninghamella elegans'' is a species of fungus in the genus '' Cunninghamella'' found in soil.
It can be grown in Sabouraud dextrose broth, a liquid medium used for cultivation of yeasts and molds from liquid which are normally sterile.
As ...
'' produces, in the case of the biodegradation of phenanthrene, a
glucoside
A glucoside is a glycoside that is derived from glucose. Glucosides are common in plants, but rare in animals. Glucose is produced when a glucoside is hydrolysed by purely chemical means, or decomposed by fermentation or enzymes.
The name was o ...
conjugate of 1-hydroxyphenanthrene (
phenanthrene 1-O-beta-glucose).
Relationship with smoking
Highly significant differences and dose-response relationships with regard to cigarettes smoked per day were found for
2-,
3- and
4-hydroxyphenanthrene and
1-hydroxypyrene, but not for 1-hydroxyphenanthrene.
[Urinary monohydroxylated phenanthrenes and hydroxypyrene – the effects of smoking habits and changes induced by smoking on monooxygenase-mediated metabolism. Heudorf U and Angerer J, International Archives of Occupational and Environmental Health, April 2001, Volume 74, Issue 3, pages 177-183, ]
References
External links
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{{DEFAULTSORT:Hydroxyphenanthrene, 1-
Phenanthrenoids
Phenolic human metabolites