(RS)-MCPG is a

phenylglycine Phenylglycine is the organic compound with the formula C6H5CH(NH2)CO2H. It is a non-proteinogenic alpha amino acid related to alanine, but with a phenyl group in place of the methyl group. It is a white solid. The compound exhibits some biolog ...

derivative and a non-selective antagonist of group I and II

metabotropic glutamate receptor The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs. Like all glutamate rece ...

s (mGluRs). It has been used in

long-term potentiation In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons ...

(LTP) as well as

long-term depression In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms dependi ...

(LTD) research and proved that certain LTP and LTD pathways depend on mGluRs. Its full chemical name is (RS)-α-methyl-4-carboxyphenylglycine. It appears as a white solid and its molecular weight is 209.2 Da. Its molecular formula is C₁₀H₁₁NO₄.

References

{{Reflist Metabotropic glutamate receptor antagonists