In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a (R)-limonene 6-monooxygenase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:(+)-(R)-limonene + NADPH + H + O
(+)-trans-carveol + NADP + HO
The 4
substrates of this enzyme are
(+)-(R)-limonene,
NADPH
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NAD ...
,
H, and
O, whereas its 3
products are
(+)-trans-carveol,
NADP, and
HO.
This enzyme belongs to the family of
oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The
systematic name of this enzyme class is (R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating). Other names in common use include (+)-limonene-6-hydroxylase, and (+)-limonene 6-monooxygenase. This enzyme participates in
monoterpenoid biosynthesis
Monoterpenes are a class of terpenes that consist of two isoprene units and have the molecular formula C10H16. Monoterpenes may be linear (acyclic) or contain rings (monocyclic and bicyclic). Modified terpenes, such as those containing oxygen funct ...
and
limonene and pinene degradation.
See also
*
CYP2C19
References
*
*
EC 1.14.13
NADPH-dependent enzymes
Enzymes of unknown structure
{{1.14.13-enzyme-stub