|
Vibralactone
Vibralactones are a group of related terpenoid chemical compounds, the first of which were isolated from the Basidiomycete ''Boreostereum vibrans ''Boreostereum'' is a genus of corticioid fungi. The genus was circumscribed in 1968 by Erast Parmasto to contain the type species, which was formerly known as ''Stereum radiatum''. ''Boreostereum'' has four species that are widely distributed ...'' in 2006. Additional vibralactones have also been isolated from the fungus '' Stereum hirsutum''. Vibralactone A has attracted research interest because it is an inhibitor of pancreatic lipase (IC50 0.4 μg/mL) with '' in vitro'' activity comparable to that of the obesity drug orlistat. Several laboratory syntheses of vibralactone A have been developed. Chemical structures References {{reflist Terpenes and terpenoids ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boreostereum Vibrans
''Boreostereum'' is a genus of corticioid fungi. The genus was circumscribed in 1968 by Erast Parmasto to contain the type species, which was formerly known as ''Stereum radiatum''. ''Boreostereum'' has four species that are widely distributed in northern temperate areas. Species in the genus have a dimitic hyphal system, and the hyphae have with brown encrustations that turn greenish when potassium hydroxide is applied. '' Boreosterum vibrans'' produces vibralactones, chemical metabolites that inhibit various enzymes. Recent phylogenetic research indicates that ''Boreostereum'' is a sister group to the rest of the Gloeophyllales The Gloeophyllales are a phylogenetically defined order of wood-decay fungi that is characterized by the ability to produce a brown rot of wood. * * * * It includes a single, identically defined family, the Gloeophyllaceae, in which are inclu .... References Gloeophyllales Agaricomycetes genera {{Agaricomycetes-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Terpenoid
The terpenoids, also known as isoprenoids, are a class of naturally occurring organic chemicals derived from the 5-carbon compound isoprene and its derivatives called terpenes, diterpenes, etc. While sometimes used interchangeably with "terpenes", terpenoids contain additional functional groups, usually containing oxygen. When combined with the hydrocarbon terpenes, terpenoids comprise about 80,000 compounds. They are the largest class of plant secondary metabolites, representing about 60% of known natural products. Many terpenoids have substantial pharmacological bioactivity and are therefore of interest to medicinal chemists. Plant terpenoids are used for their aromatic qualities and play a role in traditional herbal remedies. Terpenoids contribute to the scent of eucalyptus, the flavors of cinnamon, cloves, and ginger, the yellow color in sunflowers, and the red color in tomatoes. Well-known terpenoids include citral, menthol, camphor, salvinorin A in the plant '' Salvia di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element is therefore not a compound. A compound can be transformed into a different substance by a chemical reaction, which may involve interactions with other substances. In this process, bonds between atoms may be broken and/or new bonds formed. There are four major types of compounds, distinguished by how the constituent atoms are bonded together. Molecular compounds are held together by covalent bonds; ionic compounds are held together by ionic bonds; intermetallic compounds are held together by metallic bonds; coordination complexes are held together by coordinate covalent bonds. Non-stoichiometric compounds form a disputed marginal case. A chemical formula specifies the number of atoms of each element in a compound molecule, using the s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basidiomycete
Basidiomycota () is one of two large divisions that, together with the Ascomycota, constitute the subkingdom Dikarya (often referred to as the "higher fungi") within the kingdom Fungi. Members are known as basidiomycetes. More specifically, Basidiomycota includes these groups: mushrooms, puffballs, stinkhorns, bracket fungi, other polypores, jelly fungi, boletes, chanterelles, earth stars, smuts, bunts, rusts, mirror yeasts, and ''Cryptococcus'', the human pathogenic yeast. Basidiomycota are filamentous fungi composed of hyphae (except for basidiomycota-yeast) and reproduce sexually via the formation of specialized club-shaped end cells called basidia that normally bear external meiospores (usually four). These specialized spores are called basidiospores. However, some Basidiomycota are obligate asexual reproducers. Basidiomycota that reproduce asexually (discussed below) can typically be recognized as members of this division by gross similarity to others, by the form ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stereum Hirsutum
''Stereum hirsutum'', also called false turkey tail and hairy curtain crust, is a fungus typically forming multiple brackets on dead wood. It is also a plant pathogen infecting peach trees. ''S. hirsutum'' is in turn parasitised by certain other species such as the fungus ''Tremella aurantia''. Substrates for ''S. hirsutum'' include dead limbs and trunks of both hardwoods and conifers.USDA. 200USDA Fungal Database: ''Stereum hirsutum database''/ref> The cap is 1–4 cm wide. The spores are white. It is inedible. Similar species include ''Stereum ochraceoflavum'', ''Stereum ostrea'', and ''Trametes versicolor ''Trametes versicolor''also known as ''Coriolus versicolor'' and ''Polyporus versicolor''is a common polypore mushroom found throughout the world. Meaning 'of several colors', ''versicolor'' reliably describes this fungus that displays a variet ...''. References External links * Fungal tree pathogens and diseases Stone fruit tree diseases Fungi of Europe F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pancreatic Lipase
Triglyceride lipases () are a family of lipolytic enzymes that hydrolyse ester linkages of triglycerides. Lipases are widely distributed in animals, plants and prokaryotes. At least three tissue-specific isozymes exist in higher vertebrates, pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase (), which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL). The most conserved region in all these proteins is centred on a serine residue which has been shown to participate, with a histidine and an aspartic acid residue, in a charge relay system. Such a region is also present in lipases of prokaryotic origin and in lecithin-cholesterol acyltransferase () (LCAT), which catalyzes fatty acid transfer between phosphatidylcholine and cholesterol. Human pancreatic lipase ''Pancreatic lipase'', also known as ''pancreatic triacylglycerol lipase'' or ''steapsin'', is an enzyme secreted from the pancre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter plates. Studies conducted using components of an organism that have been isolated from their usual biological surroundings permit a more detailed or more convenient analysis than can be done with whole organisms; however, results obtained from ''in vitro'' experiments may not fully or accurately predict the effects on a whole organism. In contrast to ''in vitro'' experiments, ''in vivo'' studies are those conducted in living organisms, including humans, and whole plants. Definition ''In vitro'' ( la, in glass; often not italicized in English usage) studies are conducted using components of an organism that have been isolated fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orlistat
Orlistat, sold under the brand name Xenical among others, is a medication used to treat obesity. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet. Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium ''Streptomyces toxytricini''. However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug. The effectiveness of orlistat in promoting weight loss is definite but modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about more than those not taking the drug over the course of a year. Orlistat also modestly reduces blood pressure and appears to prevent the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
