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Tuberactinomycin
Tuberactinomycin may refer to: * Viomycin, the first tuberactinomycin found * Enviomycin Enviomycin (International Nonproprietary Name, INN, also called tuberactinomycin N) is an antibiotic drug, isolated from ''Streptomyces griseoverticillatus'' var. ''tuberacticus''. It is used in the treatment of tuberculosis. References ..., also known as tuberactinomycin N External links Deciphering Tuberactinomycin Biosynthesis: Isolation, Sequencing, and Annotation of the Viomycin Biosynthetic Gene Cluster, 2003 Sep on U.S. National Library of Medicine {{Chemistry index ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viomycin
Viomycin is a member of the tuberactinomycin family, a group of nonribosomal peptide antibiotics exhibiting anti-tuberculosis activity. The tuberactinomycin family is an essential component in the drug cocktail currently used to fight infections of ''Mycobacterium tuberculosis''. Viomycin was the first member of the tuberactinomycins to be isolated and identified, and was used to treat TB until it was replaced by the less toxic, but structurally related compound, capreomycin. The tuberactinomycins target bacterial ribosomes, binding RNA and disrupting bacterial protein synthesis and certain forms of RNA splicing. Viomycin is produced by the actinomycete ''Streptomyces puniceus''. Biosynthesis The gene cluster for viomycin has been sequenced from ''Streptomyces sp.'' strain ATCC 11861, ''Streptomyces vinaceus'' and from ''Streptomyces lividans'' 1326. It consists of a central cyclic pentapeptide code assembled from nonribosomal peptide synthetase (NRPS). The NRPS contains 4 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
