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Tubarial Glands
The tubarial salivary glands, also known as the tubarial glands, are a pair of salivary glands found in humans between the nasal cavity and throat. Description The tubarial glands are found in the lateral walls of the nasopharynx overlying the torus tubarius. The tubarial salivary glands bind to PSMA, which is how they were discovered. History The glands were discovered by a group of Dutch scientists at the Netherlands Cancer Institute in September 2020 using PET/CT scans. Significance Most of the significance of the tubarial glands stems from their significance in radiotherapy. It is believed that avoiding the irradiation of the glands will prevent many of the side effects of radiotherapy, such as xerostomia Xerostomia, also known as dry mouth, is dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause. This symptom is very common and is often seen as a side ef .... References ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salivary Gland
The salivary glands in mammals are exocrine glands that produce saliva through a system of ducts. Humans have three paired major salivary glands (parotid, submandibular, and sublingual), as well as hundreds of minor salivary glands. Salivary glands can be classified as serous, mucous, or seromucous (mixed). In serous secretions, the main type of protein secreted is alpha-amylase, an enzyme that breaks down starch into maltose and glucose, whereas in mucous secretions, the main protein secreted is mucin, which acts as a lubricant. In humans, 1200 to 1500 ml of saliva are produced every day. The secretion of saliva (salivation) is mediated by parasympathetic stimulation; acetylcholine is the active neurotransmitter and binds to muscarinic receptors in the glands, leading to increased salivation. The fourth pair of salivary glands, the tubarial glands discovered in 2020, are named for their location, being positioned in front and over the torus tubarius. However, this find ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humans
Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, and language. Humans are highly social and tend to live in complex social structures composed of many cooperating and competing groups, from families and kinship networks to political states. Social interactions between humans have established a wide variety of values, social norms, and rituals, which bolster human society. Its intelligence and its desire to understand and influence the environment and to explain and manipulate phenomena have motivated humanity's development of science, philosophy, mythology, religion, and other fields of study. Although some scientists equate the term ''humans'' with all members of the genus ''Homo'', in common usage, it generally refers to ''Homo sapiens'', the only extant member. Anatomically ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nasal Cavity
The nasal cavity is a large, air-filled space above and behind the nose in the middle of the face. The nasal septum divides the cavity into two cavities, also known as fossae. Each cavity is the continuation of one of the two nostrils. The nasal cavity is the uppermost part of the respiratory system and provides the nasal passage for inhaled air from the nostrils to the nasopharynx and rest of the respiratory tract. The paranasal sinuses surround and drain into the nasal cavity. Structure The term "nasal cavity" can refer to each of the two cavities of the nose, or to the two sides combined. The lateral wall of each nasal cavity mainly consists of the maxilla. However, there is a deficiency that is compensated for by the perpendicular plate of the palatine bone, the medial pterygoid plate, the labyrinth of ethmoid and the inferior concha. The paranasal sinuses are connected to the nasal cavity through small orifices called ostia. Most of these ostia communicate with the n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Throat
In vertebrate anatomy, the throat is the front part of the neck, internally positioned in front of the vertebrae. It contains the pharynx and larynx. An important section of it is the epiglottis, separating the esophagus from the trachea (windpipe), preventing food and drinks being inhaled into the lungs. The throat contains various blood vessels, pharyngeal muscles, the nasopharyngeal tonsil, the tonsils, the palatine uvula, the trachea, the esophagus, and the vocal cords. Mammal throats consist of two bones, the hyoid bone and the clavicle. The "throat" is sometimes thought to be synonymous for the fauces. It works with the mouth, ears and nose, as well as a number of other parts of the body. Its pharynx is connected to the mouth, allowing speech to occur, and food and liquid to pass down the throat. It is joined to the nose by the nasopharynx at the top of the throat, and to the ear by its Eustachian tube. The throat's trachea carries inhaled air to the bronchi of the lungs. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nasopharynx
The pharynx (plural: pharynges) is the part of the throat behind the mouth and nasal cavity, and above the oesophagus and trachea (the tubes going down to the stomach and the lungs). It is found in vertebrates and invertebrates, though its structure varies across species. The pharynx carries food and air to the esophagus and larynx respectively. The flap of cartilage called the epiglottis stops food from entering the larynx. In humans, the pharynx is part of the digestive system and the conducting zone of the respiratory system. (The conducting zone—which also includes the nostrils of the nose, the larynx, trachea, bronchi, and bronchioles—filters, warms and moistens air and conducts it into the lungs). The human pharynx is conventionally divided into three sections: the nasopharynx, oropharynx, and laryngopharynx. It is also important in vocalization. In humans, two sets of pharyngeal muscles form the pharynx and determine the shape of its lumen. They are arranged as an in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Torus Tubarius
The base of the cartilaginous portion of the Eustachian tube (auditory tube) lies directly under the mucous membrane of the nasal part of the pharynx, where it forms an elevation or cushion, the torus tubarius or torus of the auditory tube, behind the pharyngeal orifice of the tube. The torus tubarius is very close to the tubal tonsil, which is sometimes also called the ''tonsil of (the) torus tubarius''. Two folds run posteriorly and anteriorly: *posteriorly, the vertical fold of mucous membrane, the salpingopharyngeal fold, stretches from the lower part of the torus tubarius; it contains the Salpingopharyngeus muscle which originates from the superior border of the medial lamina of the cartilage of the auditory tube, and passes downward and blends with the posterior fasciculus of the palatopharyngeus muscle. *anteriorly, the second and smaller fold, the salpingopalatine fold, smaller than the salpingopharyngeal fold, contains some fibers of muscle, called ''salpingopalatine musc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glutamate Carboxypeptidase II
Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the ''FOLH1'' (folate hydrolase 1) gene. Human GCPII contains 750 amino acids and weighs approximately 84 kDa. GCPII is a zinc metalloenzyme that resides in membranes. Most of the enzyme resides in the extracellular space. GCPII is a class II membrane glycoprotein. It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA) according to the reaction scheme to the right. Neuroscientists primarily use the term NAALADase in their studies, while those studying folate metabolism use folate hydrolase, and those studying prostate cancer or oncology, PSMA. All of which refer to the same protein glutamate carboxypeptidase II. Discovery GCPII is mainly expressed in four tissues of the body, including prostate epithelium, the prox ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Netherlands Cancer Institute
The Netherlands Cancer Institute (NKI) in Amsterdam was founded in 1913 by, among others, the surgeon Jacob Rotgans. The NKI, together with the Antoni van Leeuwenhoekziekenhuis, is formed into the NKI-AVL, which combines a scientific research institute with a specialized clinic focused on combating the disease cancer. Since 1973 the NKI is located next to the Slotervaartziekenhuis in Amsterdam. NKI is a member of EU-LIFE, an alliance of leading life sciences research centres in Europe. Core principles of the institute are new methods for diagnostics and treatment. The primary clusters of the NKI-AVL are: Research, Surgical Oncological Disciplines, Medical Oncological Disciplines, Radiotherapy and Diagnostic Oncological Disciplines. At the start of the 1990s, the NKI, together with the VU University Amsterdam created the Research School for Oncology Amsterdam (OOA) for postdoctoral research and schooling. This research school was accredited by the Royal Netherlands Academy of Arts ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PET/CT
Positron emission tomography–computed tomography (better known as PET-CT or PET/CT) is a nuclear medicine technique which combines, in a single gantry, a positron emission tomography (PET) scanner and an x-ray computed tomography (CT) scanner, to acquire sequential images from both devices in the same session, which are combined into a single superposed ( co-registered) image. Thus, functional imaging obtained by PET, which depicts the spatial distribution of metabolic or biochemical activity in the body can be more precisely aligned or correlated with anatomic imaging obtained by CT scanning. Two- and three-dimensional image reconstruction may be rendered as a function of a common software and control system. PET-CT has revolutionized medical diagnosis in many fields, by adding precision of anatomic localization to functional imaging, which was previously lacking from pure PET imaging. For example, many diagnostic imaging procedures in oncology, surgical planning, radiation t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Hindu
''The Hindu'' is an Indian English-language daily newspaper owned by The Hindu Group, headquartered in Chennai, Tamil Nadu. It began as a weekly in 1878 and became a daily in 1889. It is one of the Indian newspapers of record and the second most circulated English-language newspaper in India, after '' The Times of India''. , ''The Hindu'' is published from 21 locations across 11 states of India. ''The Hindu'' has been a family-owned newspaper since 1905, when it was purchased by S. Kasturi Ranga Iyengar from the original founders. It is now jointly owned by Iyengar's descendants, referred to as the "Kasturi family", who serve as the directors of the holding company. The current chairperson of the group is Malini Parthasarathy, a great-granddaughter of Iyengar. Except for a period of about two years, when S. Varadarajan held the editorship of the newspaper, the editorial positions of the paper were always held by members of the family or held under their direction. Histo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ScienceAlert
ScienceAlert is an independently run online publication and news source that publishes articles featuring scientific research, discoveries and outcomes. The site was founded in 2004 by Julian Cribb, a science writer, to aggregate research findings from Australian universities, and expanded in 2006 when ex-Microsoft programmer Chris Cassella took on the project of developing the website. It has readership that ranges from 11.5m to 26.5m per month. Science journalist Fiona MacDonald has been CEO since 2017. History Science communicator Julian Cribb founded ScienceAlert in 2004. The website was borne of his “concern at the lack of information available about what Australians and New Zealanders achieve in science.” Chris Cassella, a former programmer for Microsoft, joined the site in order to develop new webtools. He took on this work as part of a Master’s thesis in Science Communication at Australia National University, where Cribb was a professor. Initially, ScienceAlert’ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiotherapy
Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally provided as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology. A physician who practices in this subspecialty is a radiation oncologist. Radiation therapy is commonly applied to the cancerous tumor because of its ability to control cell growth. Ionizing radiation works by damaging the DNA of cancerous tissue l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
