Tetramine
Tetramine is a typical name for a chemical containing four amine groups. Some examples are: * Triethylenetetramine ("trien") * Hexamethylenetetramine (hexamine) * Tetramethylenedisulfotetramine (TETS), a rodenticide banned in most countries Tetramine is also used as a synonym for the tetramethylammonium Tetramethylammonium (TMA) or (Me4N+) is the simplest quaternary ammonium cation, consisting of four methyl groups attached to a central nitrogen atom, and is isoelectronic with neopentane. It is positively charged and can only be isolated in asso ...

Tetramethylenedisulfotetramine
Tetramethylenedisulfotetramine (TETS) is an organic compound used as a rodenticide (rat poison). It is an odorless, tasteless white powder that is slightly soluble in water, DMSO and acetone, and insoluble in methanol and ethanol. It is a sulfamide derivative. It can be synthesized by reacting sulfamide with formaldehyde under acidic condition. When crystallized from acetone, it forms cubic crystals with a melting point of 255–260 °C. Toxicity and mechanism TETS is a neurotoxin and convulsant, causing lethal convulsions. Its effect is similar to but stronger than picrotoxin, a GABA-A receptor antagonist widely used in research. As one of the most hazardous pesticides, it is 100 times more toxic than potassium cyanide. TETS binds to neuronal GABA gated chloride channels, often causing status epilepticus. No antidote is known. The lethal dose for humans is 7–10 mg. Poisoning is diagnosed by GC-MS and the treatment is mainly supportive, with large IV doses of a benz ...
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Amine
In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines). Important amines include amino acids, biogenic amines, trimethylamine, and aniline; Inorganic derivatives of ammonia are also called amines, such as monochloramine (). The substituent is called an amino group. Compounds with a nitrogen atom attached to a carbonyl group, thus having the structure , are called amides and have different chemical properties from amines. Classification of amines Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. A ...
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Triethylenetetramine
Triethylenetetramine (TETA and trien), also known as trientine (INN) when used medically, is an organic compound with the formula H2NHCH2CH2NH2sub>2. The pure freebase is a colorless oily liquid, but, like many amines, older samples assume a yellowish color due to impurities resulting from air-oxidation. It is soluble in polar solvents. The branched isomer tris(2-aminoethyl)amine and piperazine derivatives may also be present in commercial samples of TETA. The hydrochloride salts are used medically as a treatment for copper toxicity. Uses The reactivity and uses of TETA are similar to those for the related polyamines ethylenediamine and diethylenetriamine. It is primarily used as a crosslinker ("hardener") in epoxy curing. Medical uses The hydrochloride salt of TETA, referred to as ''trientine hydrochloride'', is a chelating agent that is used to bind and remove copper in the body to treat Wilson's disease, particularly in those who are intolerant to penicillamine. Some r ...
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Hexamethylenetetramine
Hexamethylenetetramine, also known as methenamine, hexamine, or urotropin, is a heterocyclic organic compound with the formula (CH2)6N4. This white crystalline compound is highly soluble in water and polar organic solvents. It has a cage-like structure similar to adamantane. It is useful in the synthesis of other organic compounds, including plastics, pharmaceuticals, and rubber additives. It sublimes in vacuum at 280 °C. Synthesis, structure, reactivity Hexamethylenetetramine was discovered by Aleksandr Butlerov in 1859. In this article, Butlerov discovered formaldehyde, which he called "dioxymethylen" (methylene dioxide) age 247because his empirical formula for it was incorrect (C4H4O4). On pages 249–250, he describes treating formaldehyde with ammonia gas, creating hexamine. It is prepared industrially by combining formaldehyde and ammonia: : The reaction can be conducted in gas phase and in solution. The molecule has a tetrahedral cage-like structure, similar t ...
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Rodenticide
Rodenticides are chemicals made and sold for the purpose of killing rodents. While commonly referred to as "rat poison", rodenticides are also used to kill mice, squirrels, woodchucks, chipmunks, porcupines, nutria, beavers, and voles. Despite the crucial roles that rodents play in nature, there are times when they need to be controlled. Some rodenticides are lethal after one exposure while others require more than one. Rodents are disinclined to gorge on an unknown food (perhaps reflecting an adaptation to their inability to vomit), preferring to sample, wait and observe whether it makes them or other rats sick. This phenomenon of poison shyness is the rationale for poisons that kill only after multiple doses. Besides being directly toxic to the mammals that ingest them, including dogs, cats, and humans, many rodenticides present a secondary poisoning risk to animals that hunt or scavenge the dead corpses of rats. Classes of rodenticides Anticoagulants Anticoagulant ...
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