Taxine Alkaloids
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Taxine Alkaloids
Taxine alkaloids, which are often named under the collective title of taxines, are the toxic chemicals that can be isolated from the yew tree. The amount of taxine alkaloids depends on the species of yew, with ''Taxus baccata'' and ''Taxus cuspidata'' containing the most. The major taxine alkaloids are taxine A and taxine B although there are at least 10 different alkaloids. Until 1956, it was believed that all the taxine alkaloids were one single compound named taxine. The taxine alkaloids are cardiotoxins with taxine B being the most active. Taxine alkaloids have no medical uses but Paclitaxel and other taxanes that can be isolated from yews have been used as chemotherapy drugs. Provenance Taxine can be found in Taxus species: ''Taxus cuspidata, T. baccata'' (English yew), '' Taxus x media, Taxus canadensis, Taxus floridana,'' and ''Taxus brevifolia'' (Pacific or western yew). All of these species contain taxine in every part of the plant except in the aril, the fleshy co ...
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Taxus
''Taxus'' is a genus of coniferous trees or shrubs known as yews in the family Taxaceae. They are relatively slow-growing and can be very long-lived, and reach heights of , with trunk girth averaging . They have reddish bark, lanceolate, flat, dark-green leaves long and broad, arranged spirally on the stem, but with the leaf bases twisted to align the leaves in two flat rows either side of the stem. The oldest known fossil species are from the Early Cretaceous. Morphology The seed cones are highly modified, each cone containing a single seed long partly surrounded by a modified scale which develops into a soft, bright red berry-like structure called an aril, long and wide and open at the end. The arils are mature 6–9 months after pollination, and with the seed contained are eaten by thrushes, waxwings and other birds, which disperse the hard seeds undamaged in their droppings; maturation of the arils is spread over 2–3 months, increasing the chances of successful seed d ...
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Julius Caesar
Gaius Julius Caesar (; ; 12 July 100 BC – 15 March 44 BC), was a Roman general and statesman. A member of the First Triumvirate, Caesar led the Roman armies in the Gallic Wars before defeating his political rival Pompey in a civil war, and subsequently became dictator from 49 BC until his assassination in 44 BC. He played a critical role in the events that led to the demise of the Roman Republic and the rise of the Roman Empire. In 60 BC, Caesar, Crassus and Pompey formed the First Triumvirate, an informal political alliance that dominated Roman politics for several years. Their attempts to amass power as were opposed by the within the Roman Senate, among them Cato the Younger with the frequent support of Cicero. Caesar rose to become one of the most powerful politicians in the Roman Republic through a string of military victories in the Gallic Wars, completed by 51 BC, which greatly extended Roman territory. During this time he both invaded Britain and built a b ...
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Minimum Lethal Dose
In toxicology, the lethal dose (LD) is an indication of the lethal toxicity of a given substance or type of radiation. Because resistance varies from one individual to another, the "lethal dose" represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given ''percentage'' of subjects will die. The lethal concentration is a lethal dose measurement used for gases or particulates. The LD may be based on the standard person concept, a theoretical individual that has perfectly "normal" characteristics, and thus not apply to all sub-populations. Median lethal dose (LD50) The median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 (lethal concentration and time) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after a specified test duration. LD50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD50 is indi ...
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Atropine
Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. It is typically given intravenously or by injection into a muscle. Eye drops are also available which are used to treat uveitis and early amblyopia. The intravenous solution usually begins working within a minute and lasts half an hour to an hour. Large doses may be required to treat some poisonings. Common side effects include a dry mouth, large pupils, urinary retention, constipation, and a fast heart rate. It should generally not be used in people with angle closure glaucoma. While there is no evidence that its use during pregnancy causes birth defects, that has not been well studied. It is likely safe during breastfeeding. It is an antimuscarinic (a type of anticholinergic) that works by inhibiting the parasympathetic nervous system. Atropine occurs n ...
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Taxine B
Taxine alkaloids, which are often named under the collective title of taxines, are the toxic chemicals that can be isolated from the yew tree. The amount of taxine alkaloids depends on the species of yew, with ''Taxus baccata'' and ''Taxus cuspidata'' containing the most. The major taxine alkaloids are taxine A and taxine B although there are at least 10 different alkaloids. Until 1956, it was believed that all the taxine alkaloids were one single compound named taxine. The taxine alkaloids are cardiotoxins with taxine B being the most active. Taxine alkaloids have no medical uses but Paclitaxel and other taxanes that can be isolated from yews have been used as chemotherapy drugs. Provenance Taxine can be found in Taxus species: ''Taxus cuspidata, T. baccata'' (English yew), '' Taxus x media, Taxus canadensis, Taxus floridana,'' and ''Taxus brevifolia'' (Pacific or western yew). All of these species contain taxine in every part of the plant except in the aril, the fleshy co ...
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Taxus Baccata MHNT Seed
''Taxus'' is a genus of coniferous trees or shrubs known as yews in the family Taxaceae. They are relatively slow-growing and can be very long-lived, and reach heights of , with trunk girth averaging . They have reddish Bark (botany), bark, lanceolate, flat, dark-green leaf, leaves long and broad, arranged spirally on the stem, but with the leaf bases twisted to align the leaves in two flat rows either side of the stem. The oldest known fossil species are from the Early Cretaceous. Morphology The conifer cone, seed cones are highly modified, each cone containing a single seed long partly surrounded by a modified scale which develops into a soft, bright red Berry (botany), berry-like structure called an aril, long and wide and open at the end. The arils are mature 6–9 months after pollination, and with the seed contained are eaten by Thrush (bird), thrushes, waxwings and other birds, which disperse the hard seeds undamaged in their droppings; maturation of the arils is sprea ...
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A Pocket Full Of Rye
A, or a, is the first Letter (alphabet), letter and the first vowel of the Latin alphabet, Latin alphabet, used in the English alphabet, modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is English alphabet#Letter names, ''a'' (pronounced ), plural English alphabet#Letter names, ''aes''. It is similar in shape to the Greek alphabet#History, Ancient Greek letter alpha, from which it derives. The Letter case, uppercase version consists of the two slanting sides of a triangle, crossed in the middle by a horizontal bar. The lowercase version can be written in two forms: the double-storey a and single-storey ɑ. The latter is commonly used in handwriting and fonts based on it, especially fonts intended to be read by children, and is also found in italic type. In English grammar, "English articles, a", and its variant "English articles#Indefinite article, an", are Article (grammar)#Indefinite article, indefinite arti ...
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Agatha Christie
Dame Agatha Mary Clarissa Christie, Lady Mallowan, (; 15 September 1890 – 12 January 1976) was an English writer known for her 66 detective novels and 14 short story collections, particularly those revolving around fictional detectives Hercule Poirot and Miss Marple. She also wrote the world's longest-running play, the murder mystery ''The Mousetrap'', which has been performed in the West End since 1952. A writer during the "Golden Age of Detective Fiction", Christie has been called the "Queen of Crime". She also wrote six novels under the pseudonym Mary Westmacott. In 1971, she was made a Dame (DBE) by Queen Elizabeth II for her contributions to literature. ''Guinness World Records'' lists Christie as the best-selling fiction writer of all time, her novels having sold more than two billion copies. Christie was born into a wealthy upper middle class family in Torquay, Devon, and was largely home-schooled. She was initially an unsuccessful writer with six co ...
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Combustion Analysis
Combustion analysis is a method used in both organic chemistry and analytical chemistry to determine the elemental composition (more precisely empirical formula) of a pure organic compound by combusting the sample under conditions where the resulting combustion products can be quantitatively analyzed. Once the number of moles of each combustion product has been determined the empirical formula or a partial empirical formula of the original compound can be calculated. Applications for combustion analysis involve only the elements of carbon (C), hydrogen (H), nitrogen (N), and sulfur (S) as combustion of materials containing them convert these elements to their oxidized form (CO2, H2O, NO or NO2, and SO2) under high temperature high oxygen conditions. Notable interests for these elements involve measuring total nitrogen in food or feed to determine protein percentage, measuring sulfur in petroleum products, or measuring total organic carbon (TOC) in water. History The method was ...
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Archiv Der Pharmazie
The ''Archiv der Pharmazie'' (German pronunciation: arˈçiːf ˈdeːɐ̯ farmaˈtsiː English: ''Archive of Pharmacy'') is a monthly peer-reviewed scientific journal covering all aspects of chemistry in the life sciences. The journal was established in 1822 and is published by Wiley-VCH on behalf of the Deutsche Pharmazeutische Gesellschaft. Until 2019, the editor-in-chief was Holger Stark (Heinrich Heine University Düsseldorf). He was succeeded in 2020 by Andreas Link (University of Greifswald). History The first edition appeared in 1822 under the name ''Archiv des Apothekervereins im nördlichen Teutschland für die Pharmacie und ihre Huelfswissenschaften'' (English: ''Archive of the Pharmacists' Association in Northern Germany for Pharmacy and its Auxiliary Sciences''). From 1924 (volume 242) the journal was called ''Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft'' (English: ''Archive of Pharmacy and Reports from the German Pharmaceutical S ...
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Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ...
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