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Tisotumab Vedotin
Tisotumab vedotin, sold under the brand name Tivdak, is an antibody-drug conjugate used to treat cervical cancer. It is a combination of tisotumab, a monoclonal antibody against tissue factor, and monomethyl auristatin E (MMAE), a potent inhibitor of cell division. It is administered by infusion into a vein. Tisotumab vedotin was approved for medical use in the United States in September 2021. The U.S. Food and Drug Administration considers it to be a first-in-class medication. Adverse effects In the United States, Tivdak carries a black box warning for ocular toxicity, which occurs in up to 60% of treated patients. In clinical trials, the most common forms of ocular toxicity were dry eye, conjunctivitis, corneal damage, and blepharitis. Other common adverse effects include bleeding (occurring in approximately 60% of patients, most often nosebleed) and peripheral neuropathy (42% of patients). Like all drugs containing MMAE, tisotumab vedotin can cause inflammation o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tissue Factor
Tissue factor, also called platelet tissue factor, factor III, or CD142, is a protein encoded by the ''F3'' gene, present in subendothelial tissue and leukocytes. Its role in the clotting process is the initiation of thrombin formation from the zymogen prothrombin. Thromboplastin defines the cascade that leads to the activation of factor X—the tissue factor pathway. In doing so, it has replaced the previously named extrinsic pathway in order to eliminate ambiguity. Function The F3 gene encodes coagulation factor III, which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dry Eye
Dry or dryness most often refers to: * Lack of rainfall, which may refer to **Arid regions **Drought * Dry or dry area, relating to legal prohibition of selling, serving, or imbibing alcoholic beverages * Dry humor, deadpan * Dryness (medical) * Dryness (taste), the lack of sugar in a drink, especially an alcoholic one * Dry direct sound without reverberation Dry or DRY may also refer to: Places * Dry Brook (other), various rivers * Dry Creek (other), various rivers and towns * Dry, Loiret, a commune of the Loiret ''département'' in France * Dry River (other), various rivers and towns Art, entertainment, and media Film * ''Dry'' (2014 film), a Nigerian film directed by Stephanie Linus * ''Dry'' (2022 film), an Italian film directed by Paolo Virzì * ''The Dry'' (film), a 2020 film based on the novel by Jane Harper Literature * ''Dry'' (memoir), a 2003 memoir by Augusten Burroughs * ''The Dry'' (novel), a 2016 novel by Jane Harper Music * D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Copenhagen
Copenhagen ( or .; da, København ) is the capital and most populous city of Denmark, with a proper population of around 815.000 in the last quarter of 2022; and some 1.370,000 in the urban area; and the wider Copenhagen metropolitan area has 2,057,142 people. Copenhagen is on the islands of Zealand and Amager, separated from Malmö, Sweden, by the Øresund strait. The Øresund Bridge connects the two cities by rail and road. Originally a Viking fishing village established in the 10th century in the vicinity of what is now Gammel Strand, Copenhagen became the capital of Denmark in the early 15th century. Beginning in the 17th century, it consolidated its position as a regional centre of power with its institutions, defences, and armed forces. During the Renaissance the city served as the de facto capital of the Kalmar Union, being the seat of monarchy, governing the majority of the present day Nordic region in a personal union with Sweden and Norway ruled by the Danis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Utrecht
Utrecht ( , , ) is the List of cities in the Netherlands by province, fourth-largest city and a List of municipalities of the Netherlands, municipality of the Netherlands, capital and most populous city of the Provinces of the Netherlands, province of Utrecht (province), Utrecht. It is located in the eastern corner of the Randstad conurbation, in the very centre of mainland Netherlands, about 35 km south east of the capital Amsterdam and 45 km north east of Rotterdam. It has a population of 361,966 as of 1 December 2021. Utrecht's ancient city centre features many buildings and structures, several dating as far back as the High Middle Ages. It has been the religious centre of the Netherlands since the 8th century. It was the most important city in the Netherlands until the Dutch Golden Age, when it was surpassed by Amsterdam as the country's cultural centre and most populous city. Utrecht is home to Utrecht University, the largest university in the Netherlands, as well as seve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genmab
Genmab A/S is a Danish biotechnology company, founded in February 1999 by Florian Schönharting, at the time managing director of BankInvest Biomedical venture fund. The company is based in Copenhagen, Denmark - internationally, it operates through the subsidiaries Genmab B.V. in Utrecht, The Netherlands, Genmab U.S., Inc. in Princeton, USA, and Genmab K.K. in Tokyo, Japan. It's a dual listed company with shares traded on the Copenhagen Stock Exchange in Denmark, and on NASDAQ Global Select Market in the US. The company has 6 approved antibodies used in 6 marketed products, covering cancer indications and autoimmune diseases: Proprietary, marketed with Seagen: * Tivdak (tisotumab vedotin-tftv) for the treatment of previously treated recurrent or metastatic cervical cancer Marketed by partners: * Darzalex ( IV) (daratumumab) / Darzalex Faspro ( SC) ( daratumumab and hyaluronidase-fihj) for the treatment of all stages of multiple myeloma as combination therapy or monotherapy, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between eight and fourteen years old, approximately twenty to thirty billion cells die per day. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Induced Cell Cycle Arrest
Induced cell cycle arrest is the use of a chemical or genetic manipulation to artificially halt progression through the cell cycle. Cellular processes like genome duplication and cell division stop. It can be temporary or permanent. It is an artificial activation of naturally occurring cell cycle checkpoints, induced by exogenous stimuli controlled by an experimenter. Model organisms In an academic research context, cell cycle arrest is typically performed in model organisms and cell extracts, such as '' Saccharomyces cervisiae'' (yeast) or ''Xenopus'' oocytes (frog eggs). Frog egg cell extracts have been used extensively in cell cycle research because they are relatively large, reaching a diameter of 1mm, and so contain large amounts of protein, making protein levels more easily measurable. Purposes There are a variety of reasons a researcher may want to temporarily or permanently prevent progress through the cell cycle. Cell cycle synchronization In some experiments, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes including apoptosis, as well as preventing the accumulation of unwanted or misfolded proteins in cells. Consequently, abnormality in the regulation of proteolysis can cause disease. Proteolysis can also be used as an analytical tool for studying proteins in the laboratory, and it may also be used in industry, for example in food proc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pneumonitis
Pneumonitis describes general inflammation of lung tissue. Possible causative agents include radiation therapy of the chest, exposure to medications used during chemo-therapy, the inhalation of debris (e.g., animal dander), aspiration, herbicides or fluorocarbons and some systemic diseases. If unresolved, continued inflammation can result in irreparable damage such as pulmonary fibrosis. Pneumonitis is distinguished from pneumonia on the basis of causation as well as its manifestation. Pneumonia can be described as pneumonitis combined with consolidation and exudation of lung tissue due to infection with microorganisms. The distinction between Pneumonia and Pneumonitis can be further understood with Pneumonitis being the encapsulation of all respiratory infections (incorporating pneumonia and pulmonary fibrosis as major diseases), and pneumonia as a localized infection. For most infections, the immune response of the body is enough to control and apprehend the infection within a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peripheral Neuropathy
Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the peripheral nerves, meaning nerves beyond the brain and spinal cord. Damage to peripheral nerves may impair sensation, movement, gland, or organ function depending on which nerves are affected; in other words, neuropathy affecting motor, sensory, or autonomic nerves result in different symptoms. More than one type of nerve may be affected simultaneously. Peripheral neuropathy may be acute (with sudden onset, rapid progress) or chronic (symptoms begin subtly and progress slowly), and may be reversible or permanent. Common causes include systemic diseases (such as diabetes or leprosy), hyperglycemia-induced glycation, vitamin deficiency, medication (e.g., chemotherapy, or commonly prescribed antibiotics including metronidazole and the fluoroquinolone class of antibiotics (such as ciprofloxacin, levofloxacin, moxifloxacin)), traumatic injury, ischemia, radiation therapy, excessi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epistaxis
A nosebleed, also known as epistaxis, is bleeding from the nose. Blood can flow down into the stomach, and cause nausea and vomiting. In more severe cases, blood may come out of both nostrils. Rarely, bleeding may be so significant that low blood pressure occurs. Blood may also come up the nasolacrimal duct and out from the eye. Risk factors include trauma, including putting the finger in the nose, blood thinners, high blood pressure, alcoholism, seasonal allergies, dry weather, and inhaled corticosteroids. There are two types: anterior, which is more common; and posterior, which is less common but more serious. Anterior nosebleeds generally occur from Kiesselbach's plexus while posterior bleeds generally occur from the sphenopalatine artery. The diagnosis is by direct observation. Prevention may include the use of petroleum jelly in the nose. Initially, treatment is generally the application of pressure for at least five minutes over the lower half of the nose. If this is no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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