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Thiomolybdate
Tetrathiomolybdate, also spelled tiomolibdate (USAN), is the anion of the following salts: * Ammonium tetrathiomolybdate, a building block in bioinorganic chemistry * Bis-choline tetrathiomolybdate Tiomolibdic acid (trade name Decuprate) is a chelating agent under investigation for the treatment of cancer and of Wilson's disease, a rare and potentially fatal disease in which the body cannot regulate copper. It is developed by Wilson Therap ..., a drug for the treatment of Wilson's disease {{sia Thiometallates ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Adopted Name
A United States Adopted Name (USAN) is a unique nonproprietary name assigned to a medication marketed in the United States. Each name is assigned by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA). The USAN Program states that its goal is to select simple, informative, and unique nonproprietary names (also called generic names) for drugs by establishing logical nomenclature classifications based on pharmacological or chemical relationships. In addition to drugs, the USAN Council names agents for gene therapy and cell therapy, List of soft contact lens materials, contact lens polymers, surgical materials, diagnostics, carriers, and substances used as an excipient. The USAN Council works in conjunction with the World Health Organization (WHO) international nonproprietary name (INN) Expert Committee and national nomenclature groups to standardize drug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ammonium Tetrathiomolybdate
Ammonium tetrathiomolybdate is the chemical compound with the formula (NH4)2MoS4. This bright red ammonium salt is an important reagent in the chemistry of molybdenum and has been used as a building block in bioinorganic chemistry. The thiometallate anion has the distinctive property of undergoing oxidation at the sulfur centers concomitant with reduction of the metal from Mo(VI) to Mo(IV). Preparation and structure The salt contains the tetrahedral oS4sup>2− anion. The compound is prepared by treating solutions of molybdate, oO4sup>2− with hydrogen sulfide in the presence of ammonia: :(NH4)2MoO4 + 4 H2S → (NH4)2MoS4 + 4 H2O Reactions The anion is also an excellent ligand. For example, with Ni(II) sources, it forms i(MoS4)2sup>2−. Much of the chemistry of the thiomolybdate results from studies on salts of quaternised organic cations, such as Et4sub>2 oS4and Ph4sub>2 oS4(Et = C2H5, Ph = C6H5). These organic salts are soluble in polar organic solvents such as acetoni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bis-choline Tetrathiomolybdate
Tiomolibdic acid (trade name Decuprate) is a chelating agent under investigation for the treatment of cancer and of Wilson's disease, a rare and potentially fatal disease in which the body cannot regulate copper. It is developed by Wilson Therapeutics and used in form of the salt bis-choline tetrathiomolybdate. Wilson's disease is an autosomal recessive genetic disorder that is manifested by serious hepatic, neurologic or psychiatric symptoms. The disease is fatal if left untreated. It is estimated that approximately 1 individual in every 30,000 worldwide has Wilson's disease, corresponding to approximately 15,000 individuals in the European Union and approximately 11,000 in the United States. Bis-choline tetrathiomolybdate has been evaluated in clinical trials in patients with various forms of cancer and has received orphan designation in the US and EU as a potential therapy against Wilson's disease. Pharmacology Mechanism of action Tiomolibdic acid selectively forms highly s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
