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Thelaziasis
Thelaziasis is the term for infestation with parasitic nematodes of the genus ''Thelazia''. The adults of all ''Thelazia'' species discovered so far inhabit the eyes and associated tissues (such as eyelids, tear ducts, etc.) of various mammal and bird hosts, including humans. ''Thelazia'' nematodes are often referred to as "eyeworms". Signs and symptoms In animal and human hosts, infestation by ''Thelazia'' may be asymptomatic, though it frequently causes watery eyes ( epiphora), conjunctivitis, corneal opacity, or corneal ulcers (ulcerative keratitis). Infested humans have also reported "foreign body sensation"the feeling that something is in the eye. Cause Life cycle In the uterus of the adult female, the embryos develop into first-stage larvae (L1), which remain in the eggshell (sheath). The female deposits these sheathed larvae in the tears of the mammal or bird definitive host, and the larvae are ingested by tear-feeding flies. In the fly, the larvae "hatch" (exsheath), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thelazia Callipaeda
''Thelazia callipaeda'' is a parasitic nematode, and the most common cause of thelaziasis (or eyeworm infestation) in humans, dogs and cats. It was first discovered in the eyes of a dog in China in 1910. By 2000, over 250 human cases had been reported in the medical literature. Morphology The adult ''Thelazia callipaeda'' worm typically measures 5 to 20 mm in length and 250 to 800 µm in diameter. The males tend to be smaller than the females in size. In distinguishing this species from other worms, they have a distinct buccal capsule and a cuticle with spaced transverse striations giving it a ridged appearance. Adult females could also be identified by the position of their vulva which is anterior to the oesophagus-intestinal junction. The males can be distinguished by their possession of five pairs of postcloacal papillae. Hosts In addition to humans, cats and dogs, definitive hosts of ''T. callipaeda'' include the wolf (''Canis lupus''), raccoon dog (''Nyctereutes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thelazia
''Thelazia'' is a genus of nematode worms which parasitize the eyes and associated tissues of various bird and mammal hosts, including humans. They are often called "eyeworms", and infestation with ''Thelazia'' species is referred to as " thelaziasis" (occasionally spelled "thelaziosis"). Adults are usually found in the eyelids, tear glands, tear ducts, or the so-called "third eyelid" (nictitating membrane). Occasionally, they are found in the eyeball itself, either under the conjunctiva (the membrane that covers the white part of the eye) or in the vitreous cavity of the eyeball. All species of ''Thelazia'' for which the life cycle has been studied are transmitted by species of Diptera (flies) which do not bite, but which feed on tears. Representative species *''Thelazia anolabiata'' ( Molin, 1860) ** Definitive hosts: Andean cock-of-the-rock (''Rupicola peruviana'') and many other Brazilian birds ** Intermediate hosts: Not known ** Distribution: South America *'' Thelazia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Post-Soviet States
The post-Soviet states, also known as the former Soviet Union (FSU), the former Soviet Republics and in Russia as the near abroad (russian: links=no, ближнее зарубежье, blizhneye zarubezhye), are the 15 sovereign states that were union republics of the Soviet Union, which emerged and re-emerged from the Soviet Union following its dissolution in 1991. Russia is the primary ''de facto'' internationally recognized successor state to the Soviet Union after the Cold War; while Ukraine has, by law, proclaimed that it is a state-successor of both the Ukrainian SSR and the Soviet Union which remained under dispute over formerly Soviet-owned properties. The three Baltic states – Estonia, Latvia, and Lithuania – were the first to declare their independence from the USSR, between March and May 1990, claiming continuity from the original states that existed prior to their annexation by the Soviet Union in 1940. The remaining 12 republics all subsequently seceded, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doramectin
Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Similarly to other drugs of this family, it is produced by fermentation by selected strains of ''Streptomyces avermitilis''. Its spectrum includes: ''Haemonchus, Ostertagia, Trichostrongylus, Cooperia'', and ''Oesophagostomum'' species and ''Dictyocaulus viviparus'', ''Dermatobia hominis, Boophilus microplus'', and ''Psoroptes bovis'', among many other internal and external parasites. It is available as an injection and as a 5-mg/ml topical solution. Doramectin is also marketed in many Latin-American and some Asia and Africa countries as Doramec L.A. (manufacture ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Levamisole
Levamisole, sold under the brand name Ergamisol among others, is a medication used to treat parasitic worm infections, specifically ascariasis and hookworm infections. It is taken by mouth. Side effects may include abdominal pain, vomiting, headache, and dizziness. Use is not recommended during breastfeeding or the third trimester of pregnancy. Serious side effects may include an increased risk of infection. It belongs to the anthelmintic class of medications. Levamisole was discovered in 1966. It is on the WHO Model List of Essential Medicines, World Health Organization's List of Essential Medicines. It is not commercially available in the United States. Levamisole is also used as a dewormer for livestock. Medical uses Worms Levamisole was originally used as an anthelmintic to treat worm infestations in both humans and animals. Levamisole works as a nicotinic acetylcholine receptor agonist that causes continued stimulation of the parasitic worm muscles, leading to paralysis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ivermectin
Ivermectin (, '' EYE-vər-MEK-tin'') is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, today it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken orally, or applied to the skin for external infestations. It belongs to the avermectin family of medications. William Campbell and Satoshi Ōmura won the 2015 Nobel Prize in Physiology or Medicine for its discovery and applications. It is on the World Health Organization's List of Essential Medicines, and is approved by the U.S. Food and Drug Administration as an antiparasitic agent. In 2018, it was the 420th most commonly prescribed medication in the United States, with more than 100,000 prescriptions. It is availab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anthelmintics
Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges (those that stun) or vermicides (those that kill). Anthelmintics are used to treat people who are infected by helminths, a condition called helminthiasis. These drugs are also used to treat infected animals. Pills containing anthelmintics are used in mass deworming campaigns of school-aged children in many developing countries. The drugs of choice for soil-transmitted helminths are mebendazole and albendazole; for schistosomiasis and tapeworms it is praziquantel. Types Antiparasitics that specifically target worms of the genus ''Ascaris'' are called ascaricides. * Benzimidazoles: ** Albendazole – effective against threadworms, roundworms, whipworms, tapeworms, hookworms ** Mebendazole – effective against va ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diisopropyl Fluorophosphate
Diisopropyl fluorophosphate (DFP) or Isoflurophate is an oily, colorless liquid with the chemical formula C6H14FO3P. It is used in medicine and as an organophosphorus insecticide. It is stable, but undergoes hydrolysis when subjected to moisture. Uses in medicine Diisopropyl fluorophosphate is a parasympathomimetic drug irreversible anti-cholinesterase and has been used in ophthalmology as a miotic agent in treatment of chronic glaucoma, as a miotic in veterinary medicine, and as an experimental agent in neuroscience because of its acetylcholinesterase inhibitory properties and ability to induce delayed peripheral neuropathy. Uses as toxin The marked toxicity of esters of monofluorophosphoric acid was discovered in 1932, when Willy Lange and his PhD student Gerda von Krueger prepared the methyl, ethyl, n-propyl, and n-butyl esters and incidentally experienced their toxic effects. Another homologue of this series of esters, Diisopropyl fluorophosphate, was developed by Brit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ecothiopate Iodide
Echothiophate (Phospholine) is an irreversible acetylcholinesterase inhibitor. Uses It is used as an ocular antihypertensive in the treatment of chronic glaucoma and, in some cases, accommodative esotropia. It is available under several trade names such as Phospholine Iodide ( Wyeth-Ayerst). Echothiophate binds irreversibly to cholinesterase. Because of the very slow rate at which echothiophate is hydrolyzed by cholinesterase, its effects can last a week or more. Adverse effects include muscle spasm and other systemic effects. Mechanism of action It covalently binds by its phosphate group to serine group at the active site of the cholinesterase. Once bound, the enzyme is permanently inactive and the cell has to make new enzymes. Shortage Wyeth Pharmaceuticals stopped manufacturing echothiophate iodide in the US in 2003. After contacting the American Academy of Ophthalmology (AAO), Wyeth rescinded their decision and, according to AAO public relations representative ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Topical
A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. Many topical medications are epicutaneous, meaning that they are applied directly to the skin. Topical medications may also be inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a tooth. The word ''topical'' derives from Greek τοπικός ''topikos'', "of a place". Justification Topical drug delivery is a route of administering drugs via the skin to provide topical therapeutic effects. As skin is one of the largest and most superficial organs in the human body, pharmacists utilise it to deliver various drugs. This ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fanniidae
The Fanniidae are a small (285 species in five genera) group of true flies largely confined to the Holarctic and temperate Neotropical realms; there are 11 Afrotropical species, 29 Oriental, and 14 Australasian. Adults are medium-sized to small and usually have mainly dark body and leg colours. Males congregate in characteristic dancing swarms beneath trees; females are more retiring in habit. Larvae are characterised by their flattened bodies with striking lateral protuberances, and live as scavengers in various kinds of decaying organic matter. The lesser housefly '' Fannia canicularis'' is a worldwide synanthropic species. Fanniidae are indicators useful in forensic entomology. Identifying characteristics The Fanniidae were once a subfamily of Muscidae from which they may be distinguished by: *A (strictly) dorsal bristle is on the hind tibia below the middle and in addition to the dorsal preapical. *The axillary vein is strongly curved towards the wingtip, so if extended, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fannia
Fannia (fl. around 100 AD) was a woman of ancient Rome, notable as the granddaughter of Arria Major. Life Fannia is recorded in the writings of Pliny the Younger as a woman of fortitude and respectability. As with her grandmother, Fannia is described as a political rebel in her own right. She was married to Helvidius Priscus and followed him twice into exile, once by Nero for sympathising with two outcasts (Brutus and Cassius), then by Vespasian for opposing his reign. Eventually, Fannia herself was exiled in 93 AD for instigating the creation and publication of a biographical book about her husband under the rule of Domitian. The execution of Herennius Senecio for his own involvement gives us insight into this "mild" sentence of hers. During the trial of Senecio, he blamed the book on Fannia as she had asked him to write it, a statement that Fannia confirmed. She was asked if, and confirmed that, she had given Senecio her husband's diaries. Pliny writes that "she did not utter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
