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Targeted Radiofrequency Ablation
Targeted radiofrequency ablation (also written t-RFA) is a minimally invasive procedure to treat severe pain and discomfort caused from metastatic tumors in the vertebral body of the spine. This procedure uses radiofrequency energy to target and ablate a specific spinal tumor, causing it shrink and reduce the pressure on the surrounding nerves and tissues. The procedure minimizes damage to the vertebrae and surrounding tissues. It is used as a palliative therapy rather with the intention of treating the cancer itself. History Targeted radiofrequency ablation was first developed by DFINE, Inc., a medical device company based in San Jose, California. Its product, the STAR Tumor Ablation System received 510(k) clearance from the United States Food and Drug Administration in August 2010. It is cleared for sale in the US and CE marked in Europe. The procedure was first performed at the James Graham Brown Cancer Center located at the University of Louisville Hospital in March 2012 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metastasis
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, are metastases (mets). It is generally distinguished from cancer invasion, which is the direct extension and penetration by cancer cells into neighboring tissues. Cancer occurs after cells are genetically altered to proliferate rapidly and indefinitely. This uncontrolled proliferation by mitosis produces a primary heterogeneic tumour. The cells which constitute the tumor eventually undergo metaplasia, followed by dysplasia then anaplasia, resulting in a malignant phenotype. This malignancy allows for invasion into the circulation, followed by invasion to a second site for tumorigenesis. Some cancer cells known as circulating tumor cells acquire the ability to penetrate the walls of lymphatic or blood vessels, after which they are abl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiofrequency Ablation
Radiofrequency ablation (RFA), also called fulguration, is a medical procedure in which part of the electrical conduction system of the heart, tumor or other dysfunctional tissue is ablated using the heat generated from medium frequency alternating current (in the range of 350–500 kHz). RFA is generally conducted in the outpatient setting, using either local anesthetics or conscious sedation anesthesia. When it is delivered via catheter, it is called radiofrequency catheter ablation. Two important advantages of radio frequency current (over previously used low frequency AC or pulses of DC) are that it does not directly stimulate nerves or heart muscle and therefore can often be used without the need for general anesthesia, and that it is very specific for treating the desired tissue without significant collateral damage; due to this, it is gaining in popularity as an alternative for eligible patients who do not want to undergo surgery. Documented benefits have led to RFA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vertebra
The spinal column, a defining synapomorphy shared by nearly all vertebrates,Hagfish are believed to have secondarily lost their spinal column is a moderately flexible series of vertebrae (singular vertebra), each constituting a characteristic irregular bone whose complex structure is composed primarily of bone, and secondarily of hyaline cartilage. They show variation in the proportion contributed by these two tissue types; such variations correlate on one hand with the cerebral/caudal rank (i.e., location within the backbone), and on the other with phylogenetic differences among the vertebrate taxa. The basic configuration of a vertebra varies, but the bone is its ''body'', with the central part of the body constituting the ''centrum''. The upper (closer to) and lower (further from), respectively, the cranium and its central nervous system surfaces of the vertebra body support attachment to the intervertebral discs. The posterior part of a vertebra forms a vertebral arch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Palliative
Palliative care (derived from the Latin root , or 'to cloak') is an interdisciplinary medical caregiving approach aimed at optimizing quality of life and mitigating suffering among people with serious, complex, and often terminal illnesses. Within the published literature, many definitions of palliative care exist. The World Health Organization (WHO) describes palliative care as "an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial, and spiritual." In the past, palliative care was a disease specific approach, but today the WHO takes a more broad approach, that the principles of palliative care should be applied as early as possible to any chronic and ultimately fatal illness. Palliative care is appropriate for individuals with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San Jose, California
San Jose, officially San José (; ; ), is a major city in the U.S. state of California that is the cultural, financial, and political center of Silicon Valley and largest city in Northern California by both population and area. With a 2020 population of 1,013,240, it is the most populous city in both the Bay Area and the San Jose–San Francisco–Oakland, CA Combined Statistical Area, San Jose-San Francisco-Oakland Combined Statistical Area, which contain 7.7 million and 9.7 million people respectively, the List of largest California cities by population, third-most populous city in California (after Los Angeles and San Diego and ahead of San Francisco), and the List of United States cities by population, tenth-most populous in the United States. Located in the center of the Santa Clara Valley on the southern shore of San Francisco Bay, San Jose covers an area of . San Jose is the county seat of Santa Clara County, California, Santa Clara County and the main component of the San ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Federal Food, Drug, And Cosmetic Act
The United States Federal Food, Drug, and Cosmetic Act (abbreviated as FFDCA, FDCA, or FD&C) is a set of laws passed by the United States Congress in 1938 giving authority to the U.S. Food and Drug Administration (FDA) to oversee the safety of food, drugs, medical devices, and cosmetics. A principal author of this law was Royal S. Copeland, a three-term U.S. senator from New York. In 1968, the Electronic Product Radiation Control provisions were added to the FD&C. Also in that year the FDA formed the Drug Efficacy Study Implementation (DESI) to incorporate into FD&C regulations the recommendations from a National Academy of Sciences investigation of effectiveness of previously marketed drugs. The act has been amended many times, most recently to add requirements about bioterrorism preparations. The introduction of this act was influenced by the death of more than 100 patients due to elixir sulfanilamide, a sulfanilamide medication where the toxic solvent diethylene glycol was us ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Graham Brown
James Graham Brown (August 18, 1881 — March 20, 1969) was an American businessman and real estate developer best known as the builder of the Brown Hotel in Louisville, Kentucky and for his philanthropy. Early life Born in Madison, Indiana, he moved to Louisville in 1903 and founded, with his brother and father, the W.P. Brown and Sons Lumber Company. Brown also began developing commercial buildings, concentrated around Downtown Louisville, including the Brown Hotel, Brown Theater, Brown Garage, the Commonwealth Building (originally the Martin Brown Building), and Kentucky Towers. From 1944 until 1947, Brown owned the Newell B. McClaskey House and plantation in Bloomfield, Kentucky. (with ) Later career Brown was still involved with downtown hotel development in the 1960s, as well as suburban developments like the Brown Suburban Hotel, and a development on the site of his east end farm which eventually became Baptist Hospital East and the surrounding business and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Louisville
The University of Louisville (UofL) is a public research university in Louisville, Kentucky. It is part of the Kentucky state university system. When founded in 1798, it was the first city-owned public university in the United States and one of the first universities chartered west of the Allegheny Mountains. The university is mandated by the Kentucky General Assembly to be a "Preeminent Metropolitan Research University". It enrolls students from 118 of 120 Kentucky counties, all 50 U.S. states, and 116 countries around the world. Louisville is classified among "R1: Doctoral Universities – Very high research activity". The University of Louisville School of Medicine is touted for the first fully self-contained artificial heart transplant surgery, as well as the first successful hand transplantation in the United States. The University Hospital is also credited with the first civilian ambulance, the nation's first accident services, now known as an emergency department (ED), a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of NeuroInterventional Surgery
The ''Journal of NeuroInterventional Surgery'' is a peer-reviewed medical journal covering the field of neurointerventional surgery. It is published by the BMJ Group on behalf of the Society of NeuroInterventional Surgery. It is also the official journal of the Interventional Chapter of the Australian and New Zealand Society of Neuroradiology. It is abstracted and indexed by Current Contents, CINAHL and Index Medicus ''Index Medicus'' (''IM'') is a curated subset of MEDLINE, which is a bibliographic database of life science and biomedical science information, principally scientific journal articles. From 1879 to 2004, ''Index Medicus'' was a comprehensive b .... References External links * Society of NeuroInterventional Surgery BMJ Group academic journals English-language journals Surgery journals Academic journals established in 2009 Bimonthly journals {{surgery-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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