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Steroid Receptor Coactivator 1
The nuclear receptor coactivator 1 (''NCOA1'') is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression. NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1). Interactions Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to Protein-protein interaction, interact with: * Androgen receptor, * C-Fos, * C-jun, * CIITA, * CREB-binding protein, * Cyclin D1, * DDX17, * DDX5 and * Estrogen receptor alpha, * Glucocorticoid receptor, * NFKB1, * PCAF, * PPARGC1A, * Peroxisome proliferator-activated receptor alpha, * SNW1, * STAT3, * STAT6, * TRIP4, and * Thyro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These receptors work with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often occurs in the presence of a ligand—a molecule that affects the receptor's behavior. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up- or down-regulation of gene expression. A unique property of nuclear receptors that differentiates them from other classes of receptors is their direct control of genomic DNA. Nuclear receptors play key roles in both embryonic development a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |