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Solagran
Solagran Limited is an Australian pharmaceutical company which has developed a range of biologically active therapeutic substances derived from the live elements of the green needles of certain species of conifer tree known as ''Bioeffectives''. History Solagran brings together a significant histor Research into ''Bioeffectives'' has been undertaken for a period of approximately 80 years involving more than 3.5 million PhD. and DSc. research hours (encompassing 74 PhD.s and 80 DSc.s), making it arguably the most substantial botanicals research program ever undertaken. The extent of the effort is evidenced by the fact that the company's intellectual property encompasses 22 patent The ''Bioeffectives'' story began in Russia in the early 1930s. Intrigued by the vitality of conifer trees that remain disease free in temperature extremes ranging from ± 40 degrees Celsius, and in daylight of between 2 and 22 hours per day, a scientific team at the St Petersburg Forest Technical Aca ...
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Solagran Limited is an Australian pharmaceutical company which has developed a range of biologically active therapeutic substances derived from the live elements of the green needles of certain species of conifer tree known as ''Bioeffectives''. History Solagran brings together a significant histor Research into ''Bioeffectives'' has been undertaken for a period of approximately 80 years involving more than 3.5 million PhD. and DSc. research hours (encompassing 74 PhD.s and 80 DSc.s), making it arguably the most substantial botanicals research program ever undertaken. The extent of the effort is evidenced by the fact that the company's intellectual property encompasses 22 patent The ''Bioeffectives'' story began in Russia in the early 1930s. Intrigued by the vitality of conifer trees that remain disease free in temperature extremes ranging from ± 40 degrees Celsius, and in daylight of between 2 and 22 hours per day, a scientific team at the St Petersburg Forest Technical Aca ...
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Dolichol
Dolichol refers to any of a group of long-chain mostly unsaturated organic compounds that are made up of varying numbers of isoprene units terminating in an α-saturated isoprenoid group, containing an alcohol functional group. Functions Dolichols play a role in the co-translational modification of proteins known as ''N''-glycosylation in the form of dolichol phosphate. Dolichols function as a membrane anchor for the formation of the oligosaccharide Glc3-Man9-GlcNAc2 (where Glc is glucose, Man is mannose, and GlcNAc is ''N''-acetylglucosamine). This oligosaccharide is transferred from the dolichol donor onto certain asparagine residues (onto a specific sequence that is "Asn-X-Ser/Thr") of newly forming polypeptide chains. Dolichol is also involved in transfer of the monosaccharides to the forming Glc3-Man9-GlcNAc2-Dolichol carrier. In addition, dolichols can be adducted to proteins as a posttranslational modification, a process in which branched carbohydrate trees are forme ...
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Cell Metabolism
Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks for proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary (or intermediate) metabolism. Metabolic reactions may be categorized as ''catabolic'' – the ''breaking down'' of compounds (for example, of glucose to pyruvate by cel ...
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Pasteur Institute
The Pasteur Institute (french: Institut Pasteur) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines for anthrax and rabies. The institute was founded on 4 June 1887, and inaugurated on 14 November 1888. For over a century, the Institut Pasteur has researched infectious diseases. This worldwide biomedical research organization based in Paris was the first to isolate HIV, the virus that causes AIDS, in 1983. Over the years, it has been responsible for discoveries that have enabled medical science to control diseases such as diphtheria, tetanus, tuberculosis, poliomyelitis, influenza, yellow fever, and plague. Since 1908, ten Institut Pasteur scientists have been awarded the Nobel Prize for medicine and physiology—the 2008 Nobel Prize in Physiology or Medicine was shared between two Pasteur scientists. History The Institut Pasteur ...
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Saint Petersburg State Pediatric Medical Academy
Saint Petersburg State Pediatric Medical University (Санкт-Петербургский государственный педиатрический медицинский университет), formerly known as St. Petersburg State Pediatric Medical University (SPbSPMU) is a medical university located in Saint Petersburg, Russia, providing higher medical education with a specialization in Pediatrics. SPbSPMU has a state license and accreditation to provide training in English language, medicine according to the state standards. In June 2005, under the support of Government of Russia, State Duma, Federation Council of Russia, Russian Rector's Union, the prize-winners of ''Golden Medal: European Quality'' competition in the nomination of ''Top 100 of Russian Universities'' were awarded. Saint Petersburg State Pediatric Medical Academy was honored with a golden medal. Rector of the academy Vladimir Levanovich was named The Best Rector of The Year 2004. There are four programs ...
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Swinburne University Of Technology
Swinburne University of Technology (often simply called Swinburne) is a public research university based in Melbourne, Australia. It was founded in 1908 as the Eastern Suburbs Technical College by George Swinburne to serve those without access to further education in Melbourne's eastern suburbs. Its main campus is in Hawthorn, a suburb of Melbourne, 7.5 km from the Melbourne central business district. In addition to its main Hawthorn campus, it has campuses in the Melbourne metropolitan area at Wantirna and Croydon; in Sarawak, Malaysia; and in Sydney. In the 2020 Student Experience Survey, Swinburne was ranked equal 1st place in Victoria for the ’entire education experience’ for undergraduate students, with an overall satisfaction rate of 80 per cent. Swinburne is the only academic institution in Melbourne that offers pilot training from the aviation degrees. History Swinburne University of Technology has its origins in the Eastern Suburbs Technical College, whic ...
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Drug Addiction
Addiction is a neuropsychological disorder characterized by a persistent and intense urge to engage in certain behaviors, one of which is the usage of a drug, despite substantial harm and other negative consequences. Repetitive drug use often alters brain function in ways that perpetuate craving, and weakens (but does not completely negate) self-control. This phenomenon – drugs reshaping brain function – has led to an understanding of addiction as a brain disorder with a complex variety of psychosocial as well as neurobiological (and thus involuntary) factors that are implicated in addiction's development. Classic signs of addiction include compulsive engagement in rewarding stimuli, ''preoccupation'' with substances or behavior, and continued use despite negative consequences. Habits and patterns associated with addiction are typically characterized by immediate gratification (short-term reward), coupled with delayed deleterious effects (long-term costs). Examples o ...
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Parkinson's Disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms become more common. The most obvious early symptoms are tremor, rigidity, slowness of movement, and difficulty with walking. Cognitive and behavioral problems may also occur with depression, anxiety, and apathy occurring in many people with PD. Parkinson's disease dementia becomes common in the advanced stages of the disease. Those with Parkinson's can also have problems with their sleep and sensory systems. The motor symptoms of the disease result from the death of cells in the substantia nigra, a region of the midbrain, leading to a dopamine deficit. The cause of this cell death is poorly understood, but involves the build-up of misfolded proteins into Lewy bodies in the neurons. Collectively, the main motor symptoms are also known as ...
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Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term memory, remembering recent events. As the disease advances, symptoms can include primary progressive aphasia, problems with language, Orientation (mental), disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and challenging behaviour, behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an alle ...
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Cholesterol
Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell membranes. When chemically isolated, it is a yellowish crystalline solid. Cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acid and vitamin D. Cholesterol is the principal sterol synthesized by all animals. In vertebrates, hepatic cells typically produce the greatest amounts. It is absent among prokaryotes (bacteria and archaea), although there are some exceptions, such as '' Mycoplasma'', which require cholesterol for growth. François Poulletier de la Salle first identified cholesterol in solid form in gallstones in 1769. However, it was not until 1815 that chemist Michel Eugène Chevreul named the compound "cholesterine". Etymology The word "cholesterol" comes from the Ancient Greek ''chole-'' ...
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Liver Disease
Liver disease, or hepatic disease, is any of many diseases of the liver. If long-lasting it is termed chronic liver disease. Although the diseases differ in detail, liver diseases often have features in common. Signs and symptoms Some of the signs and symptoms of a liver disease are the following: * Jaundice * Confusion and altered consciousness caused by hepatic encephalopathy. * Thrombocytopenia and coagulopathy. * Risk of bleeding symptoms particularly taking place in gastrointestinal tract Liver diseases File:Ground glass hepatocytes high mag cropped 2.jpg, Ground glass hepatocytes File:Primary biliary cirrhosis intermed mag much cropping.jpg, Primary biliary cirrhosis File:Buddchiari2.PNG, Budd-chiari syndrome File:Non-alcoholic_fatty_liver_disease1.jpg, Micrograph of non-alcoholic fatty liver disease There are more than a hundred different liver diseases. Some of the most common are: * Fascioliasis, a parasitic infection of liver caused by a liver fluke of the genus '' ...
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Polyprenols
Polyprenols are natural long-chain isoprenoid alcohols of the general formula H-(C5H8)n-OH where n is the number of isoprene units. Any prenol with more than 4 isoprene units is a polyprenol. Polyprenols play an important function acting as natural bioregulators and are found in small quantities in various plant tissues. Dolichols, which are found in all living creatures, including humans, are their 2,3-dihydro derivatives. Sources Live trees are known to contain polyprenols. The needles of conifer trees are one of the richest sources of polyprenols. They are also present in shiitake mushrooms in trace amounts. Research Polyprenols have been studied for more than 30 years. Interest has been strongest in Russia, Europe, Japan, India, and the United States. In the early 1930s, a scientific team at the Forest Technical Academy in St Petersburg, Russia led by Fyodor Solodky, the founder of Forest Biochemistry, and Asney Agranet, began research into the composition of conifer tree ...
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