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Sendai Virus
''Murine respirovirus'', formerly ''Sendai virus'' (SeV) and previously also known as murine parainfluenza virus type 1 or hemagglutinating virus of Japan (HVJ), is an Viral envelope, enveloped,150-200 nm in diameter, a negative sense, single-stranded RNA virus of the family ''Paramyxoviridae''. It typically infects rodents and it is not pathogenic for humans or domestic animals. Sendai virus (SeV) is a member of genus ''Respirovirus''. The virus was isolated in the city of Sendai in Japan in the early 1950s. Since then, it has been actively used in research as a model pathogen. The virus is infectious for many cancer cell lines (see below), has oncolytic properties demonstrated in animal models and in naturally-occurring cancers in animals. SeV's ability to fuse eukaryotic cells and to form syncytium was used to produce hybridoma cells capable of manufacturing monoclonal antibodies in large quantities. Recent applications of SeV-based vectors include the reprogramming of som ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sendai Virus Position In The Phylogenetic Tree Of Paramixoviruses
is the capital city of Miyagi Prefecture, the largest city in the Tōhoku region. , the city had a population of 1,091,407 in 525,828 households, and is one of Japan's 20 designated cities. The city was founded in 1600 by the ''daimyō'' Date Masamune. It is nicknamed the ; there are Japanese zelkova trees lining many of the main thoroughfares such as and . In the summer, the Sendai Tanabata Festival, the largest Tanabata festival in Japan, is held. In winter, the trees are decorated with thousands of lights for the , lasting through most of December. On 11 March 2011, coastal areas of the city suffered catastrophic damage from a magnitude 9.0 offshore earthquake,UK Foreign Office 9.0 assessment [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Metapneumovirus
''Human metapneumovirus'' (HMPV) is a negative-sense single-stranded RNA virus of the family ''Pneumoviridae'' and is closely related to the ''Avian metapneumovirus'' (AMPV) subgroup C. It was isolated for the first time in 2001 in the Netherlands by using the RAP-PCR (RNA arbitrarily primed PCR) technique for identification of unknown viruses growing in cultured cells. It is the second most common cause after ''Respiratory syncytial virus'' (RSV) of lower respiratory infection in young children. The peak age of hospitalization for infants with HMPV occurs between 6–12 months of age, slightly older than the peak of RSV, which is around 2–3 months. The clinical features and severity of HMPV are similar to those of RSV. HMPV is also an important cause of disease in older adults. Taxonomy Epidemiology HMPV is associated with 5% to 40% of respiratory tract infections in hospitalized and outpatient children. The virus is distributed worldwide and, in temperate regions, has a se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ELISA
The enzyme-linked immunosorbent assay (ELISA) (, ) is a commonly used analytical biochemistry assay, first described by Eva Engvall and Peter Perlmann in 1971. The assay uses a solid-phase type of enzyme immunoassay (EIA) to detect the presence of a ligand (commonly a protein) in a liquid sample using antibodies directed against the protein to be measured. ELISA has been used as a diagnostic tool in medicine, plant pathology, and biotechnology, as well as a quality control check in various industries. In the most simple form of an ELISA, antigens from the sample to be tested are attached to a surface. Then, a matching antibody is applied over the surface so it can bind the antigen. This antibody is linked to an enzyme and then any unbound antibodies are removed. In the final step, a substance containing the enzyme's substrate is added. If there was binding, the subsequent reaction produces a detectable signal, most commonly a color change. Performing an ELISA involves at least ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serology
Serology is the scientific study of Serum (blood), serum and other body fluids. In practice, the term usually refers to the medical diagnosis, diagnostic identification of Antibody, antibodies in the serum. Such antibodies are typically formed in response to an infection (against a given microorganism), against other foreign proteins (in response, for example, to a Acute hemolytic transfusion reaction, mismatched blood transfusion), or to one's own proteins (in instances of autoimmune disease). In either case, the procedure is simple. Serological tests Serological tests are diagnostic methods that are used to identify antibodies and antigens in a patient's sample. Serological tests may be performed to diagnose infections and autoimmune illnesses, to check if a person has immunity (medical), immunity to certain diseases, and in many other situations, such as determining an individual's blood type. Serological tests may also be used in forensic serology to investigate crime scene evid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bronchopneumonia
Bronchopneumonia is a subtype of pneumonia. It is the acute inflammation of the bronchi, accompanied by inflamed patches in the nearby lobules of the lungs. citing: Webster's New World College Dictionary, Fifth Edition, Copyright 2014 It is often contrasted with lobar pneumonia; but, in clinical practice, the types are difficult to apply, as the patterns usually overlap. Topic Completed: 1 August 2011 Bronchopneumonia (lobular) often leads to lobar pneumonia as the infection progresses. The same organism may cause one type of pneumonia in one patient, and another in a different patient. Causes Bronchopneumonia is usually a bacterial pneumonia rather than being caused by viral disease. Medically reviewed by Gerhard Whitworth, RN, on April 19, 2019 It is more commonly a hospital-acquired pneumonia than a community-acquired pneumonia, in contrast to lobar pneumonia. Bronchopneumonia is less likely than lobar pneumonia to be associated with ''Streptococcus pneumoniae''. Rather, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tracheitis
Tracheitis is an inflammation of the trachea. Although the trachea is usually considered part of the lower respiratory tract, in ICD-10 tracheitis is classified under "acute upper respiratory infections". Symptoms * Increasing deep or barking croup cough following a recent upper respiratory infection * Crowing sound when inhaling (inspiratory stridor) * 'Scratchy' feeling in the throat * Chest pain * Fever * Ear ache * Headache * Dizziness (light headed) * Labored breathing Causes Bacterial tracheitis is a bacterial infection of the trachea The trachea, also known as the windpipe, is a cartilaginous tube that connects the larynx to the bronchi of the lungs, allowing the passage of air, and so is present in almost all air- breathing animals with lungs. The trachea extends from the ... and is capable of producing airway obstruction. One of the most common causes is '' Staphylococcus aureus'' and often follows a recent viral upper respiratory infection. Bacterial tracheiti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Porphyrin
Porphyrins ( ) are a group of heterocyclic macrocycle organic compounds, composed of four modified pyrrole subunits interconnected at their α carbon atoms via methine bridges (=CH−). The parent of porphyrin is porphine, a rare chemical compound of exclusively theoretical interest. Substituted porphines are called porphyrins. With a total of 26 π-electrons, of which 18 π-electrons form a planar, continuous cycle, the porphyrin ring structure is often described as aromatic. One result of the large conjugated system is that porphyrins typically absorb strongly in the visible region of the electromagnetic spectrum, i.e. they are deeply colored. The name "porphyrin" derives from the Greek word πορφύρα (''porphyra''), meaning ''purple''. Complexes of porphyrins Concomitant with the displacement of two N-''H'' protons, porphyrins bind metal ions in the N4 "pocket". The metal ion usually has a charge of 2+ or 3+. A schematic equation for these syntheses is shown: :H2porp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
C57BL/6
C57BL/6, often referred to as "C57 black 6", "C57" or "black 6", is a common inbred strain of laboratory mouse. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain, due to the availability of congenic strains, easy breeding, and robustness. Origin The inbred strain of C57BL mice was created in 1921 by C. C. Little at the Bussey Institute for Research in Applied Biology. The substrain "6" was the most popular of the surviving substrains. Little's supervisor William E. Castle had obtained the predecessor strain of C57BL/6, "mouse number 57", from Abbie Lathrop who was breeding inbred strains for mammary tumor research in collaboration with Leo Loeb at the time. Appearance and behavior C57BL/6 mice have a dark brown, nearly black coat. They are more sensitive to noise and odours and are more likely to bite than the more docile laboratory strains such as BA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electron Microscopy Of Sendai Virus
The electron ( or ) is a subatomic particle with a negative one elementary electric charge. Electrons belong to the first generation of the lepton particle family, and are generally thought to be elementary particles because they have no known components or substructure. The electron's mass is approximately 1/1836 that of the proton. Quantum mechanical properties of the electron include an intrinsic angular momentum ( spin) of a half-integer value, expressed in units of the reduced Planck constant, . Being fermions, no two electrons can occupy the same quantum state, in accordance with the Pauli exclusion principle. Like all elementary particles, electrons exhibit properties of both particles and waves: They can collide with other particles and can be diffracted like light. The wave properties of electrons are easier to observe with experiments than those of other particles like neutrons and protons because electrons have a lower mass and hence a longer de Broglie wavel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non Invasive SeV Imaging Of Variable Murine Strains
Non, non or NON can refer to: * ''Non'', a negatory word in French, Italian and Latin People *Non (given name) *Non Boonjumnong (born 1982), Thai amateur boxer * Rena Nōnen (born 1993), Japanese actress who uses the stage name "Non" since July 2016 * NON, a name used by musician Boyd Rice Other uses * ''Non'' (album), The Amenta * ''Non!'' (EP), Big Country * ''Non'' (book), a 2009 book by Japanese model Nozomi Sasaki * Non (comics), a villain of Superman in the DC Comics universe * non, language code for Old Norse * NON Records, an independent record label based in Amsterdam, Netherlands * Abbreviation of NATO's Allied Forces North Norway Command * "Non", a song by Phinehas from the album '' Till the End'' See also * nan (other) Nan or NAN may refer to: Places China * Nan County, Yiyang, Hunan, China * Nan Commandery, historical commandery in Hubei, China Thailand * Nan Province ** Nan, Thailand, the administrative capital of Nan Province * Nan River People ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzootic
Enzootic is the non-human equivalent of endemic and means, in a broad sense, "belonging to" or "native to", "characteristic of", or "prevalent in" a particular geography, race, field, area, or environment; native to an area or scope. It also has two specific meanings: * an organism being "''enzootic''" means native to a place or a specific fauna * in epizoology, an infection is said to be "''enzootic''" in a population when the infection is maintained in the population without the need for external inputs (''cf''. Endemic). See also *Epizootic In epizoology, an epizootic (from Greek: ''epi-'' upon + ''zoon'' animal) is a disease event in a nonhuman animal population analogous to an epidemic in humans. An epizootic may be restricted to a specific locale (an "outbreak"), general (an "epi ... Biodiversity {{Veterinary-med-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epizootic
In epizoology, an epizootic (from Greek: ''epi-'' upon + ''zoon'' animal) is a disease event in a nonhuman animal population analogous to an epidemic in humans. An epizootic may be restricted to a specific locale (an "outbreak"), general (an "epizootic"), or widespread ("panzootic"). High population density is a major contributing factor to epizootics. Aquaculture is an industry sometimes plagued by disease because of the large number of fish confined to a small area. Defining an epizootic can be subjective; it is based upon the number of new cases in a given animal population, during a given period, and must be judged to be a rate that substantially exceeds what is expected based on recent experience (''i.e.'' a sharp elevation in the incidence rate). Because it is based on what is "expected" or thought normal, a few cases of a very rare disease (like a transmissible spongiform encephalopathy outbreak in a cervid population) might be classified as an "epizootic", while many ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
