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Supernumerary Nipple
A supernumerary nipple is an additional instance of nipple occurring in mammals, including humans. They are often mistaken for moles. Studies variously report the prevalence of supernumerary nipples as approximately 1 in 18 and 1 in 40. https://link.springer.com/article/10.1007/s004310050944 Supernumerary nipples: prevalence, size, sex and side predilection – a prospective clinical study, H. Schmidt, European Journal of Pediatrics volume 157, pages 821–823 (1998). https://jamanetwork.com/journals/jamapediatrics/article-abstract/511138 Occurrence of Supernumerary Nipples in Newborns Francis Mimouni, MD; Paul Merlob, MD; Salomon H. Reisner, MB, ChB, Am J Dis Child. 1983;137(10):952-953. The nipples appear along the two vertical "milk lines", which start in the armpit on each side, run down through the typical nipples and end at the groin. They are classified into eight levels of completeness from a simple patch of hair to a milk-bearing breast in miniature. Types ''Polyt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Genetics
Medical genetics is the branch tics in that human genetics is a field of scientific research that may or may not apply to medicine, while medical genetics refers to the application of genetics to medical care. For example, research on the causes and inheritance of genetic disorders would be considered within both human genetics and medical genetics, while the diagnosis, management, and counselling people with genetic disorders would be considered part of medical genetics. In contrast, the study of typically non-medical phenotypes such as the genetics of eye color would be considered part of human genetics, but not necessarily relevant to medical genetics (except in situations such as albinism). ''Genetic medicine'' is a newer term for medical genetics and incorporates areas such as gene therapy, personalized medicine, and the rapidly emerging new medical specialty, predictive medicine. Scope Medical genetics encompasses many different areas, including clinical practice of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Char Syndrome
Char syndrome is an autosomal dominant congenital disease caused by mutations in TFAP2B gene which affects the development of the bones of the face as well as the heart and limbs. During embryo development, TFAP2B regulates the production of the protein AP-2β, a transcription factor that is active in the neural crest and helps regulate genes that control cell division and apoptosis. There are at least 10 mutations of this gene that have been identified in people presenting Char syndrome, which alters specific regions of the gene preventing production of the transcription factor and disrupting normal development of embryo structures. People with this condition present a very distinct facial appearance with flattened cheek bones, flat and broad tip nose, shortened distance between the nose and upper lip, triangular-shaped mouth with tick lips and strabismus. It is also characterized by a patent ductus arteriosus, which is the failure to close the ductus that connects the aorta and pu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polydactyly
Polydactyly or polydactylism (), also known as hyperdactyly, is an anomaly in humans and animals resulting in supernumerary fingers and/or toes. Polydactyly is the opposite of oligodactyly (fewer fingers or toes). Signs and symptoms In humans/animals this condition can present itself on one or both hands or feet. The extra digit is usually a small piece of soft tissue that can be removed. Occasionally it contains bone without joints; rarely it may be a complete functioning digit. The extra digit is most common on the ulnar (little finger) side of the hand, less common on the radial (thumb) side, and very rarely within the middle three digits. These are respectively known as postaxial (little finger), preaxial (thumb), and central (ring, middle, index fingers) polydactyly. The extra digit is most commonly an abnormal fork in an existing digit, or it may rarely originate at the wrist as a normal digit does. The incidence of congenital deformities in newborns is approximately 2%, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grace Sherwood
Grace White Sherwood (1660–1740), called the Witch of Pungo, is the last person known to have been convicted of witchcraft in Virginia. A farmer, healer, and midwife, she was accused by her neighbors of transforming herself into a cat, damaging crops, and causing the death of livestock. She was charged with witchcraft several times. The court ordered that Sherwood's guilt or innocence be determined by ducking her in water. If she sank, she was innocent; if she did not, she was guilty. Sherwood floated to the surface and may have spent almost eight years in jail before being released. Sherwood lived in Pungo, Princess Anne County (today part of Virginia Beach), and married James Sherwood, a planter, in 1680. The couple had three sons: John, James, and Richard. Her first case was in 1697; she was accused of casting a spell on a bull, resulting in its death, but the matter was dismissed by the agreement of both parties. The following year she was accused of witchcraft by two ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atavism
In biology, an atavism is a modification of a biological structure whereby an ancestral genetic trait reappears after having been lost through evolutionary change in previous generations. Atavisms can occur in several ways; one of which is when genes for previously existing phenotypic features are preserved in DNA, and these become expressed through a mutation that either knocks out the dominant genes for the new traits or makes the old traits dominate the new one. A number of traits can vary as a result of shortening of the fetal development of a trait (neoteny) or by prolongation of the same. In such a case, a shift in the time a trait is allowed to develop before it is fixed can bring forth an ancestral phenotype. Atavisms are often seen as evidence of evolution. In social sciences, atavism is the tendency of reversion. For example, people in the modern era reverting to the ways of thinking and acting of a former time. The word ''atavism'' is derived from the Latin ''atavus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mutations
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mitosis, or meiosis or other types of damage to DNA (such as pyrimidine dimers caused by exposure to ultraviolet radiation), which then may undergo error-prone repair (especially microhomology-mediated end joining), cause an error during other forms of repair, or cause an error during replication (translesion synthesis). Mutations may also result from insertion or deletion of segments of DNA due to mobile genetic elements. Mutations may or may not produce detectable changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity. Mutation is the ultimate source o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teratology
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology. The related term developmental toxicity includes all manifestations of abnormal development that are caused by environmental insult. These may include growth retardation, delayed mental development or other congenital disorders without any structural malformations. Teratogens are substances that may cause birth defects via a toxic effect on an embryo or fetus. Known teratogens include: retinol, thalidomide, mercury, alcohol, lead, polychlorinated biphenyls (PCBs), and 2,3,7,8-tetrachlorodibenzodioxin. Etymology The term was borrowed in 1842 from the French , where it was formed in 1830 from the Greek (word stem ), meaning "sign sent by the gods, portent, marvel, monster", and ('' -ology''), used to designate a discourse, treaty, science, theory ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chandler Bing
Chandler Muriel Bing is a fictional character from the NBC sitcom ''Friends'', portrayed by actor Matthew Perry. Chandler was born to Nora Tyler Bing, an erotic romance novelist, and Charles Bing, a gay female impersonator and star of a Las Vegas drag show called "Viva Las Gay-gas" as Helena Handbasket. Chandler is of Scottish and Swedish descent. He is an only child and is apparently from an affluent family. His parents announced their divorce to him over Thanksgiving dinner when Chandler was nine years old, an event which gave him trauma and now he refuses to celebrate the holiday in his adulthood and develop his notorious sense of humor as a defense mechanism. It is revealed in season 1 that he went to an all-boys high school. Chandler's best friends are Joey Tribbiani, who is his roommate, and Ross Geller, with whom he previously lived. He met Ross' sister, Monica Geller, and her friend, Rachel Green, while celebrating Thanksgiving at Ross' parents' house. Chandler was the f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Francisco Scaramanga
Francisco Scaramanga is a fictional character and one of the main antagonists in the James Bond novel and film version of '' The Man with the Golden Gun''. Scaramanga is an assassin who kills with his signature weapon, a pistol made of solid gold. In the novel, the character is nicknamed "Pistols" Scaramanga and is also called "Paco" (a Spanish diminutive of Francisco). In the film, the character was played by Christopher Lee (the real-life step-cousin of James Bond creator Ian Fleming). As with another of James Bond's nemeses, Ernst Stavro Blofeld, Scaramanga's name is believed to have come from a schoolmate of Fleming's, George Ambrosios (Ambrose) Scaramanga. Novel biography Francisco Scaramanga, of Spanish (Catalonia) origin, became a trick shot while a youngster, and he performed in a circus owned by his father Enrico. Francisco also cared for one of the circus elephants, which he stated was his only real friend. When the elephant went on a rampage during the circus vis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tilda Swinton
Katherine Matilda Swinton (born 5 November 1960) is a British actress. Known for her roles in independent films and blockbusters, she has received various accolades, including an Academy Award and a British Academy Film Award, in addition to nominations for three Golden Globe Awards and five Screen Actors Guild Awards. In 2020, ''The New York Times'' ranked her as one of the greatest actors of the 21st century. Swinton began her career by appearing in the experimental films ''Caravaggio'' (1986), '' The Last of England'' (1988), ''War Requiem'' (1989), and '' The Garden'' (1990). Swinton won the Volpi Cup for Best Actress at the Venice Film Festival for her portrayal of Isabella of France in ''Edward II'' (1991). She next starred in Sally Potter's ''Orlando'' (1992), for which she was nominated for the European Film Award for Best Actress. She was nominated for a Golden Globe Award for her performance in '' The Deep End'' (2001). That followed with appearances in ''Vanilla Sk ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lily Allen
Lily Rose Beatrice Allen (born 2 May 1985) is an English singer-songwriter and actress. She is the daughter of actor Keith Allen and film producer Alison Owen. Her music career began in 2005 when she made some of her vocal recordings public on Myspace and the publicity resulted in airplay on BBC Radio 1 and a contract with Regal Recordings. Her first mainstream single, "Smile", reached number one on the UK Singles Chart in July 2006. Her debut record, ''Alright, Still'', was well received, selling over 2.6 million copies worldwide and bringing Allen nominations at the Grammy Awards, the Brit Awards, and the MTV Video Music Awards. In 2009, her second studio album—''It's Not Me, It's You''—saw a genre shift, having more of an electropop feel, rather than the ska and reggae influences of the first one. The album debuted at number one on the UK Albums Chart and the Australian ARIA Charts and was well received by critics, noting the singer's musical evolution and maturit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mark Wahlberg
Mark Robert Michael Wahlberg (born June 5, 1971), former stage name Marky Mark, is an American actor, businessman, and former rapper. He has received multiple accolades, including a BAFTA Award, and nominations for two Academy Awards, three Golden Globe Awards, nine Primetime Emmy Awards, and three Screen Actors Guild Awards. Wahlberg was born in Boston, Massachusetts in 1971. In the 1990s, Wahlberg was a member of the music group Marky Mark and the Funky Bunch, with whom he released the albums '' Music for the People'' (1991) and ''You Gotta Believe'' (1992). Wahlberg made his screen debut in ''Renaissance Man'' (1994) and had his first starring role in ''Fear'' (1996). He received critical praise for his performance as porn actor Dirk Diggler in '' Boogie Nights'' (1997). In the early 2000s, he ventured into big-budget action movies, such as '' The Perfect Storm'' (2000), ''Planet of the Apes'' (2001), and ''The Italian Job'' (2003). He was nominated for the Academy Aw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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