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Sophoradin
Sophoradin is an isoprenyl chalconoid, a type of polyphenolic compound, found in ''Sophora tonkinensis'', an herb used in traditional Chinese medicine. Sofalcone is an oral gastrointestinal medication and a synthetic analog Analog or analogue may refer to: Computing and electronics * Analog signal, in which information is encoded in a continuous variable ** Analog device, an apparatus that operates on analog signals *** Analog electronics, circuits which use analog ... of sophoradin. References Chalconoids {{phenol-stub ...
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Chalconoid
Chalconoids Greek: χαλκός ''khalkós'', "copper", due to its color), also known as ''chalcones'', are natural phenols related to chalcone. They form the central core for a variety of important biological compounds. They show antibacterial, antifungal, antitumor and anti-inflammatory properties. Some chalconoids demonstrated the ability to block voltage-dependent potassium channels. Chalcones are also natural aromatase inhibitors. Chalcones are aromatic ketones with two phenyl rings that are also intermediates in the synthesis of many biological compounds. The closure of hydroxychalcones causes the formation of the flavonoid structure. Flavonoids are substances in the plant secondary metabolism with an array of biological activities. Chalconoids are also intermediates in the Auwers synthesis of flavones. Chemical properties Biosynthesis and metabolism Chalcone synthase is an enzyme responsible for the production of chalconoids in plants. Chalcone isomerase is responsi ...
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Sophora Tonkinensis
''Sophora tonkinensis'' is a herb used in traditional Chinese medicine Traditional Chinese medicine (TCM) is an alternative medical practice drawn from traditional medicine in China. It has been described as "fraught with pseudoscience", with the majority of its treatments having no logical mechanism of action .... Sofalcone is an oral gastrointestinal medication and a synthetic derivative of sophoradin, an isoprenyl chalcone found in ''S. tonkinensis''. References External links tonkinensis {{Sophoreae-stub ...
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Traditional Chinese Medicine
Traditional Chinese medicine (TCM) is an alternative medical practice drawn from traditional medicine in China. It has been described as "fraught with pseudoscience", with the majority of its treatments having no logical mechanism of action. Medicine in traditional China encompassed a range of sometimes competing health and healing practices, folk beliefs, literati theory and Confucian philosophy, herbal remedies, food, diet, exercise, medical specializations, and schools of thought. In the early twentieth century, Chinese cultural and political modernizers worked to eliminate traditional practices as backward and unscientific. Traditional practitioners then selected elements of philosophy and practice and organized them into what they called "Chinese medicine" (''Zhongyi''). In the 1950s, the Chinese government sponsored the integration of Chinese and Western medicine, and in the Great Proletarian Cultural Revolution of the 1960s, promoted Chinese medicine as inexpensive a ...
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Sofalcone
Sofalcone (INN) is an oral gastrointestinal medication used in Japan. It is a synthetic analog of sophoradin, a type of natural phenol found in ''Sophora tonkinensis'', an herb used in traditional Chinese medicine Traditional Chinese medicine (TCM) is an alternative medical practice drawn from traditional medicine in China. It has been described as "fraught with pseudoscience", with the majority of its treatments having no logical mechanism of action .... References Drugs acting on the gastrointestinal system and metabolism Phenol ethers Chalconoids {{gastrointestinal-drug-stub ...
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Analog (chemistry)
A structural analog (analogue in modern traditional English; Commonwealth English), also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound. Structural analogs are often isoelectronic. Despite a high chemical similarity, structural analogs are not necessarily functional analogs and can have very different physical, chemical, biochemical, or pharmacological properties. In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study or a database is screened for structural analogs of a lead compound. Chemical analogues of il ...
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