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Rosehip Neuron
Rosehip neurons are inhibitory GABAergic neurons present in the first layer (the molecular layer) of the human cerebral cortex. They make up about 10-15% of all inhibitory neurons in Layer 1. Neurons of this type (having "large ‘rosehip’-like axonal boutons and compact arborization") exist in humans, but have not been reported in rodents. Rosehip neurons are named after the rose hip fruit due to the axon terminal's resemblance to their berries. These rosehip cells show an immunohistochemical profile (GAD1+ CCK+, CNR1– SST–CALB2– PVALB–) matching a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex. Rosehip cells in layer 1 make homotypic gap junctions, predominantly target apical dendritic shafts of layer 3 pyramidal neurons, and inhibit backpropagating pyramidal action potentials in microdomains of the dendritic tuft. These cells are therefore positioned for potent local control of distal dendritic comp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GABAergic
In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter GABA. For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic neuron produces GABA. A substance is GABAergic if it produces its effects via interactions with the GABA system, such as by stimulating or blocking neurotransmission. A GABAergic or GABAnergic agent is any chemical that modifies the effects of GABA in the body or brain. Some different classes of GABAergic drugs include agonists, antagonists, modulators, reuptake inhibitors and enzymes. See also * GABA reuptake inhibitor * Adenosinergic * Adrenergic * Cannabinoidergic * Cholinergic * Dopaminergic * Glycinergic * Histaminergic * Melatonergic * Monoaminergic * Opioidergic * Serotonergic Serotonergic () or serotoninergic () means "pertaining to or affecting serotonin". Serotonin is a neurotransmitter. A synapse is serotonergic if it uses serotonin as its neurotr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PVALB
Parvalbumin (PV) is a calcium-binding protein with low molecular weight (typically 9-11 kDa). In humans, it is encoded by the ''PVALB'' gene. It is not a member of the albumin family; it is named for its size (''parv-'', from Latin ''parvus'' small) and its ability to coagulate. It has three EF hand motifs and is structurally related to calmodulin and troponin C. Parvalbumin is found in fast-contracting muscles, where its levels are highest, as well as in the brain and some endocrine tissues. Parvalbumin is a small, stable protein containing EF-hand type calcium binding sites. It is involved in calcium signaling. Typically, this protein is broken into three domains, domains AB, CD and EF, each individually containing a helix-loop-helix motif. The AB domain houses a two amino-acid deletion in the loop region, whereas domains CD and EF contain the N-terminal and C-terminal, respectively. Calcium binding proteins like parvalbumin play a role in many physiological processes, namely c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebral Cortex
The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of allocortex. It is separated into two cortices, by the longitudinal fissure that divides the cerebrum into the left and right cerebral hemispheres. The two hemispheres are joined beneath the cortex by the corpus callosum. The cerebral cortex is the largest site of neural integration in the central nervous system. It plays a key role in attention, perception, awareness, thought, memory, language, and consciousness. The cerebral cortex is part of the brain responsible for cognition. In most mammals, apart from small mammals that have small brains, the cerebral cortex is folded, providing a greater surface area in the confined volume of the cranium. Apart from minimising brain and cranial volume, cortical folding is crucial for the brain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endorestiform Nucleus
Endorestiform nucleus is a nucleus present within the inferior cerebellar peduncle of human brains. It was discovered by George Paxinos and his team at Neuroscience Research Australia (NeuRA). Paxinos had suspected the existence of the endorestiform nucleus for approximately 30 years. However, it was not until 2018 that he has been able to confirm its presence due to advances in staining and imaging techniques. The region is not present in rhesus monkeys and may be unique to humans. Etymology The name ''endorestiform'' is derived from the fact that the nucleus is present within (''endo'') the inferior cerebellar peduncle ( ''restiform'' body). Function Given that the endorestiform nucleus is located in the inferior cerebellar peduncle, it is thought that it might be involved in fine motor control. According to George Paxinos, its discovery might help researchers find cures for disorders such as Parkinson's disease and motor neuron disease. See also *Rosehip neuron Rosehip neurons ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seattle
Seattle ( ) is a seaport city on the West Coast of the United States. It is the seat of King County, Washington. With a 2020 population of 737,015, it is the largest city in both the state of Washington and the Pacific Northwest region of North America. The Seattle metropolitan area's population is 4.02 million, making it the 15th-largest in the United States. Its growth rate of 21.1% between 2010 and 2020 makes it one of the nation's fastest-growing large cities. Seattle is situated on an isthmus between Puget Sound (an inlet of the Pacific Ocean) and Lake Washington. It is the northernmost major city in the United States, located about south of the Canadian border. A major gateway for trade with East Asia, Seattle is the fourth-largest port in North America in terms of container handling . The Seattle area was inhabited by Native Americans for at least 4,000 years before the first permanent European settlers. Arthur A. Denny and his group of travelers, subsequ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allen Institute For Brain Science
The Allen Institute for Brain Science is a division of the Allen Institute, based in Seattle, Washington, that focuses on bioscience research. Founded in 2003, it is dedicated to accelerating the understanding of how the human brain works. With the intent of catalyzing brain research in different areas, the Allen Institute provides free data and tools to scientists. Started with $100 million in seed money from Microsoft co-founder and philanthropist Paul Allen in 2003, the institute tackles projects at the leading edge of science—far-reaching projects at the intersection of biology and technology. The resulting data create free, publicly available resources that fuel discovery for countless researchers. Hongkui Zeng is the director of the institute.Allen Institute For ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hungary
Hungary ( hu, Magyarország ) is a landlocked country in Central Europe. Spanning of the Carpathian Basin, it is bordered by Slovakia to the north, Ukraine to the northeast, Romania to the east and southeast, Serbia to the south, Croatia and Slovenia to the southwest, and Austria to the west. Hungary has a population of nearly 9 million, mostly ethnic Hungarians and a significant Romani minority. Hungarian, the official language, is the world's most widely spoken Uralic language and among the few non-Indo-European languages widely spoken in Europe. Budapest is the country's capital and largest city; other major urban areas include Debrecen, Szeged, Miskolc, Pécs, and Győr. The territory of present-day Hungary has for centuries been a crossroads for various peoples, including Celts, Romans, Germanic tribes, Huns, West Slavs and the Avars. The foundation of the Hungarian state was established in the late 9th century AD with the conquest of the Carpathian Basin by Hungar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Szeged
Szeged ( , ; see also #Etymology, other alternative names) is List of cities and towns of Hungary#Largest cities in Hungary, the third largest city of Hungary, the largest city and regional centre of the Southern Great Plain and the county seat of Csongrád-Csanád County, Csongrád-Csanád county. The University of Szeged is one of the most distinguished universities in Hungary. The Szeged Open Air (Theatre) Festival (first held in 1931) is one of the main attractions, held every summer and celebrated as the Day of the City on 21 May. Etymology The name ''Szeged'' might come from an old Hungarian language, Hungarian word for 'corner' (), pointing to the turn of the river Tisza that flows through the city. Others say it derives from the Hungarian word which means 'island'. Others still contend that means 'dark blond' () – a reference to the color of the water where the rivers Tisza and Mureș (river), Maros merge. The city has its own name in a number of foreign language ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Szeged
, mottoeng = Truth. Bravery. Freedom. , established = , type = Public research university , founder = Emperor Franz Joseph I , affiliation = European University Association, Science Without Borders, Confucius Institute , budget = US$220 million , chancellor = Judit Fendler , rector = László Rovó , students = 22,693 , undergrad = 17,384 , postgrad = 2,668 , doctoral = 714 , other = 3,997 (international) , city = Szeged , country = Hungary , coordinates = , campus = Urban , language = Hungarian, English , colours = Blue , website = , academic_staff = 1,968 , administrative_staff = 2,200 The University of Szeged ( hu, Szegedi Tudományegyetem, ) is a public research university in Szeged, Hungary. Established as the Jesuit Academy of Kolozsvár in present-day Cluj-Napoca in 1581, the institution was re-established as a university in 1872 by Emperor Franz Joseph I. The university relocated to Szeged in 1921, making it one of the oldest research universitie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neural Backpropagation
Neural backpropagation is the phenomenon in which, after the action potential of a neuron creates a voltage spike down the axon (normal propagation), another impulse is generated from the soma and propagates towards the apical portions of the dendritic arbor or dendrites (from which much of the original input current originated). In addition to active backpropagation of the action potential, there is also passive electrotonic spread. While there is ample evidence to prove the existence of backpropagating action potentials, the function of such action potentials and the extent to which they invade the most distal dendrites remain highly controversial. Mechanism When the graded excitatory postsynaptic potentials (EPSPs) depolarize the soma to spike threshold at the axon hillock, first, the axon experiences a propagating impulse through the electrical properties of its voltage-gated sodium and voltage-gated potassium channels. An action potential occurs in the axon first as resear ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
