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Rheobase
Rheobase is a measure of membrane potential excitability. In neuroscience, rheobase is the minimal current amplitude of infinite duration (in a practical sense, about 300 milliseconds) that results in the depolarization threshold of the cell membranes being reached, such as an action potential or the contraction of a muscle. In Greek, the root ''rhe'' translates to "current or flow", and ''basi'' means "bottom or foundation": thus the rheobase is the minimum current that will produce an action potential or muscle contraction. Rheobase can be best understood in the context of the strength-duration relationship (Fig. 1). The ease with which a membrane can be stimulated depends on two variables: the strength of the stimulus, and the duration for which the stimulus is applied.Boinagrov, D., et al. (2010). "Strength-duration relationship for extracellular neural stimulation: Numerical and analytical models". ''Journal of Neurophysiology'', 194(2010), 2236–2248. These variables are i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rheobase Chronaxie
Rheobase is a measure of membrane potential excitability. In neuroscience, rheobase is the minimal current amplitude of infinite duration (in a practical sense, about 300 milliseconds) that results in the depolarization threshold of the cell membranes being reached, such as an action potential or the contraction of a muscle. In Greek, the root ''rhe'' translates to "current or flow", and ''basi'' means "bottom or foundation": thus the rheobase is the minimum current that will produce an action potential or muscle contraction. Rheobase can be best understood in the context of the strength-duration relationship (Fig. 1). The ease with which a membrane can be stimulated depends on two variables: the strength of the stimulus, and the duration for which the stimulus is applied.Boinagrov, D., et al. (2010). "Strength-duration relationship for extracellular neural stimulation: Numerical and analytical models". ''Journal of Neurophysiology'', 194(2010), 2236–2248. These variables are i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronaxie
Chronaxie is the minimum time required for an electric current double the strength of the rheobase to stimulate a muscle or a neuron. Rheobase is the lowest intensity with indefinite pulse duration which just stimulated muscles or nerves. Chronaxie is dependent on the density of voltage-gated sodium channels in the cell, which affect that cell’s excitability. Chronaxie varies across different types of tissue: fast-twitch muscles have a lower chronaxie, slow-twitch muscles have a higher one. Chronaxie is the tissue-excitability parameter that permits choice of the optimum stimulus pulse duration for stimulation of any excitable tissue. Chronaxie (c) is the Lapicque descriptor of the stimulus pulse duration for a current of twice rheobasic (b) strength, which is the threshold current for an infinitely long-duration stimulus pulse. Lapicque showed that these two quantities (c,b) define the strength-duration curve for current: I = b(1+c/d), where d is the pulse duration. However, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Machado–Joseph Disease
Machado–Joseph disease (MJD), also known as Machado–Joseph Azorean disease, Machado's disease, Joseph's disease or spinocerebellar ataxia type 3 (SCA3), is a rare autosomal dominantly inherited neurodegenerative disease that causes progressive cerebellar ataxia,Paulson, H. (8 March 2011). Spinocerebellar Ataxia Type 3. In R. A. Pagon, T. D. Bird, C. R. Dolan, & K. Stephens (Eds.), GeneReviews. Seattle, WA: University of Washington. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK1196/ which results in a lack of muscle control and coordination of the upper and lower extremities. The symptoms are caused by a genetic mutation that results in an expansion of abnormal "CAG" trinucleotide repeats in the ATXN3 gene that results in an abnormal form of the protein ataxin which causes degeneration of cells in the hindbrain. Some symptoms, such as clumsiness and rigidity, make MJD commonly mistaken for drunkenness or Parkinson's disease. Machado–Joseph disease is a type of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulus (physiology)
In physiology, a stimulus is a detectable change in the physical or chemical structure of an organism's internal or external environment. The ability of an organism or organ to detect external stimuli, so that an appropriate reaction can be made, is called sensitivity (excitability). Sensory receptors can receive information from outside the body, as in touch receptors found in the skin or light receptors in the eye, as well as from inside the body, as in chemoreceptors and mechanoreceptors. When a stimulus is detected by a sensory receptor, it can elicit a reflex via stimulus transduction. An internal stimulus is often the first component of a homeostatic control system. External stimuli are capable of producing systemic responses throughout the body, as in the fight-or-flight response. In order for a stimulus to be detected with high probability, its level of strength must exceed the absolute threshold; if a signal does reach threshold, the information is transmitted to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pulse (signal Processing)
A pulse in signal processing is a rapid, transient change in the amplitude of a signal from a baseline value to a higher or lower value, followed by a rapid return to the baseline value. Pulse shapes Pulse shapes can arise out of a process called pulse-shaping. Optimum pulse shape depends on the application. Rectangular pulse These can be found in pulse waves, square waves, boxcar functions, and rectangular functions. In digital signals the up and down transitions between high and low levels are called the rising edge and the falling edge. In digital systems the detection of these sides or action taken in response is termed edge-triggered, rising or falling depending on which side of rectangular pulse. A digital timing diagram is an example of a well-ordered collection of rectangular pulses. Nyquist pulse A Nyquist pulse is one which meets the Nyquist ISI criterion and is important in data transmission. An example of a pulse which meets this condition is the sinc function. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
X-intercept
In mathematics, a zero (also sometimes called a root) of a real-, complex-, or generally vector-valued function f, is a member x of the domain of f such that f(x) ''vanishes'' at x; that is, the function f attains the value of 0 at x, or equivalently, x is the solution to the equation f(x) = 0. A "zero" of a function is thus an input value that produces an output of 0. A root of a polynomial is a zero of the corresponding polynomial function. The fundamental theorem of algebra shows that any non-zero polynomial has a number of roots at most equal to its degree, and that the number of roots and the degree are equal when one considers the complex roots (or more generally, the roots in an algebraically closed extension) counted with their multiplicities. For example, the polynomial f of degree two, defined by f(x)=x^2-5x+6 has the two roots (or zeros) that are 2 and 3. f(2)=2^2-5\times 2+6= 0\textf(3)=3^2-5\times 3+6=0. If the function maps real numbers to real numbers, then it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Slope
In mathematics, the slope or gradient of a line is a number that describes both the ''direction'' and the ''steepness'' of the line. Slope is often denoted by the letter ''m''; there is no clear answer to the question why the letter ''m'' is used for slope, but its earliest use in English appears in O'Brien (1844) who wrote the equation of a straight line as and it can also be found in Todhunter (1888) who wrote it as "''y'' = ''mx'' + ''c''". Slope is calculated by finding the ratio of the "vertical change" to the "horizontal change" between (any) two distinct points on a line. Sometimes the ratio is expressed as a quotient ("rise over run"), giving the same number for every two distinct points on the same line. A line that is decreasing has a negative "rise". The line may be practical – as set by a road surveyor, or in a diagram that models a road or a roof either as a description or as a plan. The ''steepness'', incline, or grade of a line is measured by the absolute ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ampere
The ampere (, ; symbol: A), often shortened to amp,SI supports only the use of symbols and deprecates the use of abbreviations for units. is the unit of electric current in the International System of Units (SI). One ampere is equal to electrons worth of charge moving past a point in a second. It is named after French mathematician and physicist André-Marie Ampère (1775–1836), considered the father of electromagnetism along with Danish physicist Hans Christian Ørsted. As of the 2019 redefinition of the SI base units, the ampere is defined by fixing the elementary charge to be exactly C ( coulomb), which means an ampere is an electrical current equivalent to elementary charges moving every seconds or elementary charges moving in a second. Prior to the redefinition the ampere was defined as the current that would need to be passed through 2 parallel wires 1 metre apart to produce a magnetic force of newtons per metre. The earlier CGS system had two definitio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electric Current
An electric current is a stream of charged particles, such as electrons or ions, moving through an electrical conductor or space. It is measured as the net rate of flow of electric charge through a surface or into a control volume. The moving particles are called charge carriers, which may be one of several types of particles, depending on the conductor. In electric circuits the charge carriers are often electrons moving through a wire. In semiconductors they can be electrons or holes. In an electrolyte the charge carriers are ions, while in plasma, an ionized gas, they are ions and electrons. The SI unit of electric current is the ampere, or ''amp'', which is the flow of electric charge across a surface at the rate of one coulomb per second. The ampere (symbol: A) is an SI base unit. Electric current is measured using a device called an ammeter. Electric currents create magnetic fields, which are used in motors, generators, inductors, and transformers. In ordinary con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electric Charge
Electric charge is the physical property of matter that causes charged matter to experience a force when placed in an electromagnetic field. Electric charge can be ''positive'' or ''negative'' (commonly carried by protons and electrons respectively). Like charges repel each other and unlike charges attract each other. An object with an absence of net charge is referred to as neutral. Early knowledge of how charged substances interact is now called classical electrodynamics, and is still accurate for problems that do not require consideration of quantum effects. Electric charge is a conserved property; the net charge of an isolated system, the amount of positive charge minus the amount of negative charge, cannot change. Electric charge is carried by subatomic particles. In ordinary matter, negative charge is carried by electrons, and positive charge is carried by the protons in the nuclei of atoms. If there are more electrons than protons in a piece of matter, it will have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linear Equation
In mathematics, a linear equation is an equation that may be put in the form a_1x_1+\ldots+a_nx_n+b=0, where x_1,\ldots,x_n are the variables (or unknowns), and b,a_1,\ldots,a_n are the coefficients, which are often real numbers. The coefficients may be considered as parameters of the equation, and may be arbitrary expressions, provided they do not contain any of the variables. To yield a meaningful equation, the coefficients a_1, \ldots, a_n are required to not all be zero. Alternatively, a linear equation can be obtained by equating to zero a linear polynomial over some field, from which the coefficients are taken. The solutions of such an equation are the values that, when substituted for the unknowns, make the equality true. In the case of just one variable, there is exactly one solution (provided that a_1\ne 0). Often, the term ''linear equation'' refers implicitly to this particular case, in which the variable is sensibly called the ''unknown''. In the case of two vari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asymptote
In analytic geometry, an asymptote () of a curve is a line such that the distance between the curve and the line approaches zero as one or both of the ''x'' or ''y'' coordinates tends to infinity. In projective geometry and related contexts, an asymptote of a curve is a line which is tangent to the curve at a point at infinity. The word asymptote is derived from the Greek ἀσύμπτωτος (''asumptōtos'') which means "not falling together", from ἀ priv. + σύν "together" + πτωτ-ός "fallen". The term was introduced by Apollonius of Perga in his work on conic sections, but in contrast to its modern meaning, he used it to mean any line that does not intersect the given curve. There are three kinds of asymptotes: ''horizontal'', ''vertical'' and ''oblique''. For curves given by the graph of a function , horizontal asymptotes are horizontal lines that the graph of the function approaches as ''x'' tends to Vertical asymptotes are vertical lines near which the fun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
