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Retrograde Perfusion
Retrograde perfusion (retroperfusion) is an artificial method of providing blood supply to an organ by delivering oxygenated blood through the veins. It may be performed during surgery that interrupts the normal arterial supply of blood to that organ. For instance, when performing surgery that interrupts the cerebral arteries, a hose placed into the femoral artery and the superior vena cava can redirect blood up the internal jugular vein to supply the brain. This technique was pioneered by Oscar Langendorff, who perfused mamallian hearts ex vivo for research applications. Thus, it is often called Langendorff perfusion.Bell, R., Mocanu, M. & Yellon, D. Retrograde heart perfusion: The Langendorff technique of isolated heart perfusion. Journal of Molecular and Cellular Cardiology 50, 940-950 (2011). See also * Langendorff heart * Perfusion Perfusion is the passage of fluid through the circulatory system or lymphatic system to an organ or a tissue, usually referring to the de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vein
Veins are blood vessels in humans and most other animals that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are the pulmonary and umbilical veins, both of which carry oxygenated blood to the heart. In contrast to veins, arteries carry blood away from the heart. Veins are less muscular than arteries and are often closer to the skin. There are valves (called ''pocket valves'') in most veins to prevent backflow. Structure Veins are present throughout the body as tubes that carry blood back to the heart. Veins are classified in a number of ways, including superficial vs. deep, pulmonary vs. systemic, and large vs. small. * Superficial veins are those closer to the surface of the body, and have no corresponding arteries. *Deep veins are deeper in the body and have corresponding arteries. *Perforator veins drain from the superficial to the deep veins. These are usually referred to in the lower limbs and feet. *Communic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arterial
An artery (plural arteries) () is a blood vessel in humans and most animals that takes blood away from the heart to one or more parts of the body (tissues, lungs, brain etc.). Most arteries carry oxygenated blood; the two exceptions are the pulmonary and the umbilical arteries, which carry deoxygenated blood to the organs that oxygenate it (lungs and placenta, respectively). The effective arterial blood volume is that extracellular fluid which fills the arterial system. The arteries are part of the circulatory system, that is responsible for the delivery of oxygen and nutrients to all cells, as well as the removal of carbon dioxide and waste products, the maintenance of optimum blood pH, and the circulation of proteins and cells of the immune system. Arteries contrast with veins, which carry blood back towards the heart. Structure The anatomy of arteries can be separated into gross anatomy, at the macroscopic level, and microanatomy, which must be studied with a microscop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hose (tubing)
A hose is a flexible hollow tube designed to carry fluids from one location to another. Hoses are also sometimes called ''pipes'' (the word ''pipe'' usually refers to a rigid tube, whereas a hose is usually a flexible one), or more generally '' tubing''. The shape of a hose is usually cylindrical (having a circular cross section). Hose design is based on a combination of application and performance. Common factors are size, pressure rating, weight, length, straight hose or coilhose, and chemical compatibility. Applications mostly use nylon, polyurethane, polyethylene, PVC, or synthetic or natural rubbers, based on the environment and pressure rating needed. In recent years, hoses can also be manufactured from special grades of polyethylene (LDPE and especially LLDPE). Other hose materials includPTFE(Teflon), stainless steel, and other metals. Dredge rubber hoses have a long story, which features high strength and flexibility. A flexible dredging hose widely used in dredgers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Femoral Artery
The femoral artery is a large artery in the thigh and the main arterial supply to the thigh and leg. The femoral artery gives off the deep femoral artery or profunda femoris artery and descends along the anteromedial part of the thigh in the femoral triangle. It enters and passes through the adductor canal, and becomes the popliteal artery as it passes through the adductor hiatus in the adductor magnus near the junction of the middle and distal thirds of the thigh. Structure The femoral artery enters the thigh from behind the inguinal ligament as the continuation of the external iliac artery. Here, it lies midway between the anterior superior iliac spine and the symphysis pubis (Mid-inguinal point). Segments In clinical parlance, the femoral artery has the following segments: *The common femoral artery (CFA) is the segment of the femoral artery between the inferior margin of the inguinal ligament and the branching point of the deep femoral artery/profunda femoris artery. Its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Superior Vena Cava
The superior vena cava (SVC) is the superior of the two venae cavae, the great venous trunks that return deoxygenated blood from the systemic circulation to the right atrium of the heart. It is a large-diameter (24 mm) short length vein that receives venous return from the upper half of the body, above the diaphragm. Venous return from the lower half, below the diaphragm, flows through the inferior vena cava. The SVC is located in the anterior right superior mediastinum. It is the typical site of central venous access via a central venous catheter or a peripherally inserted central catheter. Mentions of "the cava" without further specification usually refer to the SVC. Structure The superior vena cava is formed by the left and right brachiocephalic veins, which receive blood from the upper limbs, head and neck, behind the lower border of the first right costal cartilage. It passes vertically downwards behind first intercostal space and receives azygos vein just before it p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Internal Jugular Vein
The internal jugular vein is a paired jugular vein that collects blood from the brain and the superficial parts of the face and neck. This vein runs in the carotid sheath with the common carotid artery and vagus nerve. It begins in the posterior compartment of the jugular foramen, at the base of the skull. It is somewhat dilated at its origin, which is called the ''superior bulb''. This vein also has a common trunk into which drains the anterior branch of the retromandibular vein, the facial vein, and the lingual vein. It runs down the side of the neck in a vertical direction, being at one end lateral to the internal carotid artery, and then lateral to the common carotid artery, and at the root of the neck, it unites with the subclavian vein to form the brachiocephalic vein (innominate vein); a little above its termination is a second dilation, the ''inferior bulb''. Above, it lies upon the rectus capitis lateralis, behind the internal carotid artery and the nerves passing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oscar Langendorff
Oskar Langendorff (1 February 1853 in Breslau – 10 May 1908 in Rostock; his first name is sometimes given as "Oscar") was a German physician and physiologist known primarily for his experiments on the isolated perfused heart, the so-called Langendorff Heart apparatus. In addition, he is credited with discoveries in respiration and in the conduction of impulses in the sympathetic and peripheral nervous system. His work has served as the basis for the use of retrograde perfusion in science and medicine. Scientific career After studying medicine in Wrocław (Breslau), Berlin and Freiburg im Breisgau Langendorff obtained his Ph.D. at the University of Königsberg in 1875, subsequently working there as a research assistant. He received his habilitation in 1879 with the physiologist Ludimar Hermann and after 1884 held a post as associate professor. In 1886, he was elected to membership in the German Academy of Sciences Leopoldina. From 1892 till his death in 1908 Langendorff was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Langendorff Heart
The Langendorff heart or isolated perfused heart assay is an ''ex vivo'' technique used in pharmacological and physiological research using animals and also humans. It allows the examination of cardiac contractile strength and heart rate without the complications of an intact animal or human. After 90 years this method is still being used. Method In the Langendorff preparation, the heart is removed from the animal's or human's body, severing the blood vessels; it is then perfused in a reverse fashion ( retrograde perfusion) via the aorta, usually with a nutrient rich, oxygenated solution (e.g. Krebs–Henseleit solution or Tyrode's solution). The backwards pressure causes the aortic valve to shut, forcing the solution into the coronary vessels, which normally supply the heart tissue with blood. This feeds nutrients and oxygen to the cardiac muscle, allowing it to continue beating for several hours after its removal from the animal or human. This is a useful preparation becau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Perfusion
Perfusion is the passage of fluid through the circulatory system or lymphatic system to an organ or a tissue, usually referring to the delivery of blood to a capillary bed in tissue. Perfusion is measured as the rate at which blood is delivered to tissue, or volume of blood per unit time (blood flow) per unit tissue mass. The SI unit is m3/(s·kg), although for human organs perfusion is typically reported in ml/min/g. The word is derived from the French verb "perfuser" meaning to "pour over or through". All animal tissues require an adequate blood supply for health and life. Poor perfusion (malperfusion), that is, ischemia, causes health problems, as seen in cardiovascular disease, including coronary artery disease, cerebrovascular disease, peripheral artery disease, and many other conditions. Tests verifying that adequate perfusion exists are a part of a patient's assessment process that are performed by medical or emergency personnel. The most common methods include evalua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isolated Organ Perfusion Technique
Isolated organ perfusion technique is employed to precipitate an organ's perfusion and circulation that are independent/isolated from the body's systemic circulation for various purposes such as organ-localized chemotherapy, organ-targeted delivery of drug, gene or anything else, organ transplantation, and organ injury recovery. The technique has been widely studied in animal and human for decades. Before the implementation, the perfusion system will be selected and the process can be similar to organ bath. Isolated organ perfusion technique, nevertheless, is averagely conducted in vivo without leaving the organ alone as a whole out of the body. See also * ECMO Extracorporeal membrane oxygenation (ECMO), also known as extracorporeal life support (ECLS), is an extracorporeal technique of providing prolonged cardiac and respiratory support to persons whose heart and lungs are unable to provide an adequate ... References {{Vascular surgery procedures Oncology Organ donation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
