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Retinal Mosaic
Retinal mosaic is the name given to the distribution of any particular type of neuron across any particular layer in the retina. Typically such distributions are somewhat regular; it is thought that this is so that each part of the retina is served by each type of neuron in processing visual information. The regularity of retinal mosaics can be quantitatively studied by modelling the mosaic as a spatial point pattern. This is done by treating each cell as a single point and using spatial statistics such as the Effective Radius, Packing Factor and Regularity Index. Using adaptive optics, it is nowadays possible to image the photoreceptor mosaic (i.e. the distribution of rods and cones) in living humans, enabling the detailed study of photoreceptor density and arrangement across the retina.PLoS One. 2018 Jan 16;13(1):e0191141. doi: 10.1371/journal.pone.0191141. eCollection 2018. In the fovea (where photoreceptor density is highest) the spacing between adjacent receptors is about 6 ...
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Neuron
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. Non-animals like plants and fungi do not have nerve cells. Neurons are typically classified into three types based on their function. Sensory neurons respond to stimuli such as touch, sound, or light that affect the cells of the sensory organs, and they send signals to the spinal cord or brain. Motor neurons receive signals from the brain and spinal cord to control everything from muscle contractions to glandular output. Interneurons connect neurons to other neurons within the same region of the brain or spinal cord. When multiple neurons are connected together, they form what is called a neural circuit. A typical neuron consists of a cell body ( soma), dendrites, and a single axon. The soma is a compact structure, and the axo ...
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Retina
The retina (from la, rete "net") is the innermost, light-sensitive layer of tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which then processes that image within the retina and sends nerve impulses along the optic nerve to the visual cortex to create visual perception. The retina serves a function which is in many ways analogous to that of the film or image sensor in a camera. The neural retina consists of several layers of neurons interconnected by synapses and is supported by an outer layer of pigmented epithelial cells. The primary light-sensing cells in the retina are the photoreceptor cells, which are of two types: rods and cones. Rods function mainly in dim light and provide monochromatic vision. Cones function in well-lit conditions and are responsible for the perception of colour through the use of a range of opsins, as well as high-acuity vision used fo ...
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Point Pattern Analysis
Point pattern analysis (PPA) is the study of ''point patterns'', the spatial arrangements of points in space (usually 2-dimensional space). The simplest formulation is a set ''X'' = where ''D'', which can be called the 'study region,' is a subset of R''n'', a ''n''-dimensional Euclidean space. Description The easiest way to visualize a 2-D point pattern is a map of the locations, which is simply a scatterplot but with the provision that the axes are equally scaled. If D is not the boundary of the map then it should also be indicated. An empirical definition of D would be the convex hull of the points, or at least their bounding box, a matrix of the ranges of the coordinates. Another straightforward way to visualize the points is a 2D histogram (sometimes called a quadrats) that bins the points into rectangular regions. A benefit of quadrat analysis is that it forces the analysis to take into account possible scales within which statistically significant inhomogeneities may be occ ...
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Adaptive Optics
Adaptive optics (AO) is a technology used to improve the performance of optical systems by reducing the effect of incoming wavefront distortions by deforming a mirror in order to compensate for the distortion. It is used in astronomical telescopes and laser communication systems to remove the effects of atmospheric distortion, in microscopy, optical fabrication and in retinal imaging systems to reduce optical aberrations. Adaptive optics works by measuring the distortions in a wavefront and compensating for them with a device that corrects those errors such as a deformable mirror or a liquid crystal array. Adaptive optics should not be confused with active optics, which works on a longer timescale to correct the primary mirror geometry. Other methods can achieve resolving power exceeding the limit imposed by atmospheric distortion, such as speckle imaging, aperture synthesis, and lucky imaging, or by moving outside the atmosphere with space telescopes, such as the Hubb ...
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Photoreceptor Cell
A photoreceptor cell is a specialized type of neuroepithelial cell found in the retina that is capable of visual phototransduction. The great biological importance of photoreceptors is that they convert light (visible electromagnetic radiation) into signals that can stimulate biological processes. To be more specific, photoreceptor proteins in the cell absorb photons, triggering a change in the cell's membrane potential. There are currently three known types of photoreceptor cells in mammalian eyes: rods, cones, and intrinsically photosensitive retinal ganglion cells. The two classic photoreceptor cells are rods and cones, each contributing information used by the visual system to form an image of the environment, sight. Rods primarily mediate scotopic vision (dim conditions) whereas cones primarily mediate to photopic vision (bright conditions), but the processes in each that supports phototransduction is similar. A third class of mammalian photoreceptor cell was di ...
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Fovea Centralis
The fovea centralis is a small, central pit composed of closely packed cones in the eye. It is located in the center of the macula lutea of the retina. The fovea is responsible for sharp central vision (also called foveal vision), which is necessary in humans for activities for which visual detail is of primary importance, such as reading and driving. The fovea is surrounded by the ''parafovea'' belt and the ''perifovea'' outer region. The parafovea is the intermediate belt, where the ganglion cell layer is composed of more than five layers of cells, as well as the highest density of cones; the perifovea is the outermost region where the ganglion cell layer contains two to four layers of cells, and is where visual acuity is below the optimum. The perifovea contains an even more diminished density of cones, having 12 per 100 micrometres versus 50 per 100 micrometres in the most central fovea. That, in turn, is surrounded by a larger peripheral area, which delivers highly comp ...
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Angular Resolution
Angular resolution describes the ability of any image-forming device such as an optical or radio telescope, a microscope, a camera, or an eye, to distinguish small details of an object, thereby making it a major determinant of image resolution. It is used in optics applied to light waves, in antenna theory applied to radio waves, and in acoustics applied to sound waves. The colloquial use of the term "resolution" sometimes causes confusion; when an optical system is said to have a high resolution or high angular resolution, it means that the perceived distance, or actual angular distance, between resolved neighboring objects is small. The value that quantifies this property, ''θ,'' which is given by the Rayleigh criterion, is low for a system with a high resolution. The closely related term spatial resolution refers to the precision of a measurement with respect to space, which is directly connected to angular resolution in imaging instruments. The Rayleigh criterion sh ...
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Arc Minute
A minute of arc, arcminute (arcmin), arc minute, or minute arc, denoted by the symbol , is a unit of angular measurement equal to of one degree. Since one degree is of a turn (or complete rotation), one minute of arc is of a turn. The nautical mile (nmi) was originally defined as the arc length of a minute of latitude on a spherical Earth, so the actual Earth circumference is very near . A minute of arc is of a radian. A second of arc, arcsecond (arcsec), or arc second, denoted by the symbol , is of an arcminute, of a degree, of a turn, and (about ) of a radian. These units originated in Babylonian astronomy as sexagesimal subdivisions of the degree; they are used in fields that involve very small angles, such as astronomy, optometry, ophthalmology, optics, navigation, land surveying, and marksmanship. To express even smaller angles, standard SI prefixes can be employed; the milliarcsecond (mas) and microarcsecond (μas), for instance, are commonly used in astro ...
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Visual Acuity
Visual acuity (VA) commonly refers to the clarity of vision, but technically rates an examinee's ability to recognize small details with precision. Visual acuity is dependent on optical and neural factors, i.e. (1) the sharpness of the retinal image within the eye, (2) the health and functioning of the retina, and (3) the sensitivity of the interpretative faculty of the brain. The most commonly referred visual acuity is the far acuity (e.g. 6/6 or 20/20 acuity), which describes the examinee's ability to recognize small details at a far distance, and is relevant to people with myopia; however, for people with hyperopia, the near acuity is used instead to describe the examinee's ability to recognize small details at a near distance. A common cause of low visual acuity is refractive error (ametropia), errors in how the light is refracted in the eyeball, and errors in how the retinal image is interpreted by the brain. The latter is the primary cause for low vision in people with ...
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Visual System
The visual system comprises the sensory organ (the eye) and parts of the central nervous system (the retina containing photoreceptor cells, the optic nerve, the optic tract and the visual cortex) which gives organisms the sense of sight (the ability to detect and process visible light) as well as enabling the formation of several non-image photo response functions. It detects and interprets information from the optical spectrum perceptible to that species to "build a representation" of the surrounding environment. The visual system carries out a number of complex tasks, including the reception of light and the formation of monocular neural representations, colour vision, the neural mechanisms underlying stereopsis and assessment of distances to and between objects, the identification of a particular object of interest, motion perception, the analysis and integration of visual information, pattern recognition, accurate motor coordination under visual guidance, and more. T ...
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