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Rhinal Cortex
The rhinal cortex is the cortex surrounding the rhinal fissure, including the entorhinal cortex and the perirhinal cortex. It is a cortical region in the medial temporal lobe that is made up of Brodmann areas 28, 34, 35 and 36. Input from all sensory cortices flows to the perirhinal and parahippocampal cortices, whence it continues to the entorhinal cortex and then the hippocampus. After feedback from the hippocampus, information then returns in the reverse sequence to the sensory cortices. Explicit memory The rhinal cortex is proposed to be part of the neural circuit for explicit memory. Studies comparing the results of selective lesions of the hippocampus and of the rhinal cortex found that lesions of the hippocampus alone did not impair performance on object recognition tests, but that lesions of the rhinal cortex alone caused severe anterograde and retrograde impairments on these tests. The conclusion was that object recognition (semantic memory Semantic memory re ...
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Rhinal Fissure
In the human brain, the entorhinal cortex appears as a longitudinal elevation anterior to the parahippocampal gyrus, with a corresponding internal furrow, the external rhinal sulcus (or rhinal fissure), separating it from the inferiolateral surface of the hemisphere close to the lamina terminalis. It is analogous to the collateral fissure The collateral fissure (or sulcus) is on the tentorial surface of the hemisphere and extends from near the occipital pole to within a short distance of the temporal pole. Behind, it lies below and lateral to the calcarine fissure, from which it ... found further caudally in the inferior part of the temporal lobe. References External links * http://www.sylvius.com/?s=248&i=str-208&l=1 Sulci (neuroanatomy) {{Neuroanatomy-stub ...
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Hippocampus
The hippocampus (via Latin from Greek , 'seahorse') is a major component of the brain of humans and other vertebrates. Humans and other mammals have two hippocampi, one in each side of the brain. The hippocampus is part of the limbic system, and plays important roles in the consolidation of information from short-term memory to long-term memory, and in spatial memory that enables navigation. The hippocampus is located in the allocortex, with neural projections into the neocortex in humans, as well as primates. The hippocampus, as the medial pallium, is a structure found in all vertebrates. In humans, it contains two main interlocking parts: the hippocampus proper (also called ''Ammon's horn''), and the dentate gyrus. In Alzheimer's disease (and other forms of dementia), the hippocampus is one of the first regions of the brain to suffer damage; short-term memory loss and disorientation are included among the early symptoms. Damage to the hippocampus can also result from ...
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Retrograde Amnesia
In neurology, retrograde amnesia (RA) is a loss of memory-access to events that occurred or information that was learned in the past. It is caused by an injury or the onset of a disease. It tends to negatively affect episodic, autobiographical, and declarative memory, while keeping procedural memory intact without increasing difficulty for learning new information. RA can be temporally graded, or more permanent based on the severity of its cause. It is usually consistent with Ribot's law. The law states that subjects are more likely to lose memories closer to the traumatic incident than more memories that happened further from the incident.Wixted, J. T. (2004). The psychology and neuroscience of forgetting, ''Annual Review of Psychology'', ''55'', 235–69. The type of information that is forgotten can range from a specific memory, such as a single event, or a more general memory. This would resemble generic amnesia. Anterograde amnesia is a similar condition that deals with the ...
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Anterograde Amnesia
In neurology, anterograde amnesia is the inability to create new memories after the event that caused amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remain intact. This is in contrast to retrograde amnesia, where memories created prior to the event are lost while new memories can still be created. Both can occur together in the same patient. To a large degree, anterograde amnesia remains a mysterious ailment because the precise mechanism of storing memories is not yet well understood, although it is known that the regions of the brain involved are certain sites in the temporal cortex, especially in the hippocampus and nearby subcortical regions. Signs and symptoms People with anterograde amnesic syndromes may present with widely varying degrees of forgetfulness. Some with severe cases have a combined form of anterograde and retrograde amnesia, sometimes called global amnesia. In the case of drug-i ...
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Lesions
A lesion is any damage or abnormal change in the tissue of an organism, usually caused by disease or trauma. ''Lesion'' is derived from the Latin "injury". Lesions may occur in plants as well as animals. Types There is no designated classification or naming convention for lesions. Since lesions can occur anywhere in the body and the definition of a lesion is so broad, the varieties of lesions are virtually endless. Generally, lesions may be classified by their patterns, their sizes, their locations, or their causes. They can also be named after the person who discovered them. For example, Ghon lesions, which are found in the lungs of those with tuberculosis, are named after the lesion's discoverer, Anton Ghon. The characteristic skin lesions of a varicella zoster virus infection are called ''chickenpox''. Lesions of the teeth are usually called dental caries. Location Lesions are often classified by their tissue types or locations. For example, a "skin lesion" or a " brai ...
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Explicit Memory
Explicit memory (or declarative memory) is one of the two main types of long-term human memory, the other of which is implicit memory. Explicit memory is the conscious, intentional recollection of factual information, previous experiences, and concepts. This type of memory is dependent upon three processes: acquisition, consolidation, and retrieval. Explicit memory can be divided into two categories: episodic memory, which stores specific personal experiences, and semantic memory, which stores factual information.Tulving E. 1972. Episodic and semantic memory. In Organization of Memory, ed. E Tulving, W Donaldson, pp. 381–403. New York: Academic Explicit memory requires gradual learning, with multiple presentations of a stimulus and response. The counterpart to explicit memory is known as implicit memory, refers to memories acquired and used unconsciously such as skills (e.g. knowing how to get dressed) or perception. Unlike explicit memory, implicit memory learns rapidly, even ...
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Neural Circuit
A neural circuit is a population of neurons interconnected by synapses to carry out a specific function when activated. Neural circuits interconnect to one another to form large scale brain networks. Biological neural networks have inspired the design of artificial neural networks, but artificial neural networks are usually not strict copies of their biological counterparts. Early study Early treatments of neural networks can be found in Herbert Spencer's ''Principles of Psychology'', 3rd edition (1872), Theodor Meynert's ''Psychiatry'' (1884), William James' ''Principles of Psychology'' (1890), and Sigmund Freud's Project for a Scientific Psychology (composed 1895). The first rule of neuronal learning was described by Hebb in 1949, in the Hebbian theory. Thus, Hebbian pairing of pre-synaptic and post-synaptic activity can substantially alter the dynamic characteristics of the synaptic connection and therefore either facilitate or inhibit signal transmission. In 1959, the neur ...
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Parahippocampal Gyrus
The parahippocampal gyrus (or hippocampal gyrus') is a grey matter cortical region of the brain that surrounds the hippocampus and is part of the limbic system. The region plays an important role in memory encoding and retrieval. It has been involved in some cases of hippocampal sclerosis. Asymmetry has been observed in schizophrenia. Structure The anterior part of the gyrus includes the perirhinal and entorhinal cortices. The term parahippocampal cortex is used to refer to an area that encompasses both the posterior parahippocampal gyrus and the medial portion of the fusiform gyrus. Function Scene recognition The parahippocampal place area (PPA) is a sub-region of the parahippocampal cortex that lies medially in the inferior temporo-occipital cortex. PPA plays an important role in the encoding and recognition of environmental scenes (rather than faces). fMRI studies indicate that this region of the brain becomes highly active when human subjects view topographical scene sti ...
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Entorhinal Cortex
The entorhinal cortex (EC) is an area of the brain's allocortex, located in the medial temporal lobe, whose functions include being a widespread network hub for memory, navigation, and the perception of time.Integrating time from experience in the lateral entorhinal cortex Albert Tsao, Jørgen Sugar, Li Lu, Cheng Wang, James J. Knierim, May-Britt Moser & Edvard I. Moser Naturevolume 561, pages57–62 (2018) The EC is the main interface between the hippocampus and neocortex. The EC-hippocampus system plays an important role in declarative (autobiographical/episodic/semantic) memories and in particular spatial memories including memory formation, memory consolidation, and memory optimization in sleep. The EC is also responsible for the pre-processing (familiarity) of the input signals in the reflex nictitating membrane response of classical trace conditioning; the association of impulses from the eye and the ear occurs in the entorhinal cortex. Structure In rodents, the EC ...
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Perirhinal Cortex
The perirhinal cortex is a cortical region in the medial temporal lobe that is made up of Brodmann areas 35 and 36. It receives highly processed sensory information from all sensory regions, and is generally accepted to be an important region for memory. It is bordered caudally by postrhinal cortex or parahippocampal cortex (homologous regions in rodents and primates, respectively) and ventrally and medially by entorhinal cortex. Structure The perirhinal cortex is composed of two regions: areas 36 and 35. Area 36 is sometimes divided into three subdivisions: 36d is the most rostral and dorsal, 36r ventral and caudal, and 36c the most caudal. Area 35 can be divided in the same manner, into 35d and 35v (for dorsal and ventral, respectively). Area 36 is six-layered, dysgranular, meaning that its layer IV is relatively sparse. Area 35 is agranular cortex (lacking any cells in layer IV). Function The perirhinal cortex is involved in both visual perception and memory; it fac ...
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Cerebral Cortex
The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of allocortex. It is separated into two cortices, by the longitudinal fissure that divides the cerebrum into the left and right cerebral hemispheres. The two hemispheres are joined beneath the cortex by the corpus callosum. The cerebral cortex is the largest site of neural integration in the central nervous system. It plays a key role in attention, perception, awareness, thought, memory, language, and consciousness. The cerebral cortex is part of the brain responsible for cognition. In most mammals, apart from small mammals that have small brains, the cerebral cortex is folded, providing a greater surface area in the confined volume of the cranium. Apart from minimising brain and cranial volume, cortical folding is crucial for the brain ...
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