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Pseudohermaphrodite
Pseudohermaphroditism is a condition in which an individual has a matching chromosomal and gonadal tissue (ovary or testis) sex, but mismatching external genitalia. Female pseudohermaphroditism refers to an individual with ovaries and external genitalia resembling those of a male. Male pseudohermaphroditism refers to an individual with testes and external genitalia resembling those of a female. In some cases, external sex organs associated with pseudohermaphroditism appear intermediate between a typical clitoris and penis. Thus, pseudohermaphroditism is sometimes not identified until puberty or adulthood. The term contrasts with true hermaphroditism, a condition describing an individual with both female and male reproductive organs. Associated conditions include 5-α-reductase deficiency and androgen insensitivity syndrome. Mechanism Sex is determined by chromosomes during fertilization. In the early stages of human development, a human embryo has the precursors of female (p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intersex
Intersex people are individuals born with any of several sex characteristics including chromosome patterns, gonads, or genitals that, according to the Office of the United Nations High Commissioner for Human Rights, "do not fit typical binary notions of male or female bodies". Sex assignment at birth usually aligns with a child's anatomical sex and phenotype. The number of births with ambiguous genitals is in the range of 1:2000–1:4500 (0.022%–0.05%). Other conditions involve atypical chromosomes, gonads, or hormones. Some persons may be assigned and raised as a girl or boy but then identify with another gender later in life, while most continue to identify with their assigned sex. The number of births where the baby is intersex has been reported differently depending on who reports and which definition of intersex is used. Anne Fausto-Sterling and her co-authors suggest that the prevalence of "nondimorphic sexual development" might be as high as 1.7%. A study publish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intersex Activism
Intersex people are individuals born with any of several sex characteristics including chromosome patterns, gonads, or genitals that, according to the Office of the United Nations High Commissioner for Human Rights, "do not fit typical binary notions of male or female bodies". Sex assignment at birth usually aligns with a child's anatomical sex and phenotype. The number of births with ambiguous genitals is in the range of 1:2000–1:4500 (0.022%–0.05%). Other conditions involve atypical chromosomes, gonads, or hormones. Some persons may be assigned and raised as a girl or boy but then identify with another gender later in life, while most continue to identify with their assigned sex. The number of births where the baby is intersex has been reported differently depending on who reports and which definition of intersex is used. Anne Fausto-Sterling and her co-authors suggest that the prevalence of "nondimorphic sexual development" might be as high as 1.7%. A study publis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Androgen Insensitivity Syndrome
Androgen insensitivity syndrome (AIS) is a difference in sex development involving hormonal resistance due to androgen receptor dysfunction. It affects 1 in 20,000 to 64,000 XY ( karyotypically male) births. The condition results in the partial or complete inability of cells to respond to androgens. This unresponsiveness can impair or prevent the development of male genitals, as well as impairing or preventing the development of male secondary sexual characteristics at puberty. It does not significantly impair female genital or sexual development. The insensitivity to androgens is therefore clinically significant only when it occurs in genetic males, (i.e. individuals with a Y-chromosome, or more specifically, an SRY gene). Clinical phenotypes in these individuals range from a typical male habitus with mild spermatogenic defect or reduced secondary terminal hair, to a full female habitus, despite the presence of a Y-chromosome. AIS is divided into three categories that are d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complete Androgen Insensitivity Syndrome
Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens. As such, the insensitivity to androgens is only clinically significant when it occurs in individuals who are exposed to significant amounts of testosterone at some point in their lives. The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does allow, without significant impairment, female genital and sexual development in those with the condition. All human fetuses begin fetal development looking similar, with both the Müllerian duct system (female) and the Wolffian duct system (male) developing. It is at the seventh week of gestation that the bodies of unaffected individuals with the XY karyotype begin their masculinization: i.e., the Wolffian duct system is pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disorders Of Sex Development
Disorders of sex development (DSDs), also known as differences in sex development, diverse sex development and variations in sex characteristics (VSC), are congenital conditions affecting the reproductive system, in which development of chromosomal, gonadal, or anatomical sex is atypical. DSDs are subdivided into groups in which the labels generally emphasize the karyotype's role in diagnosis: 46,XX; 46,XY; sex chromosome; XX, sex reversal; ovotesticular disorder; and XY, sex reversal. Overview DSDs are medical conditions encompassing any problem noted at birth where the genitalia are atypical in relation to the chromosomes or gonads. There are several types of DSDs and their effect on the external and internal reproductive organs varies greatly. A frequently-used social and medical adjective for people with DSDs is "intersex". Urologists were concerned that terms like intersex, hermaphrodite, and pseudohermaphrodite were confusing and pejorative. This led to the Chicago Consen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clitoris
The clitoris ( or ) is a female sex organ present in mammals, ostriches and a limited number of other animals. In humans, the visible portion – the glans – is at the front junction of the labia minora (inner lips), above the opening of the urethra. Unlike the penis, the male homologue (equivalent) to the clitoris, it usually does not contain the distal portion (or opening) of the urethra and is therefore not used for urination. In most species, the clitoris lacks any reproductive function. While few animals urinate through the clitoris or use it reproductively, the spotted hyena, which has an especially large clitoris, urinates, mates, and gives birth via the organ. Some other mammals, such as lemurs and spider monkeys, also have a large clitoris. The clitoris is the human female's most sensitive erogenous zone and generally the primary anatomical source of human female sexual pleasure. In humans and other mammals, it develops from an outgrowth in the embry ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Money
John William Money (8 July 1921 – 7 July 2006) was a New Zealand psychologist, sexologist and author known for his research into sexual identity and Sex determination and differentiation (human), biology of gender. He was one of the first researchers to publish theories on the influence of societal constructs of gender on individual formation of gender identity. Money introduced the terms ''gender role'' and ''sexual orientation'' and popularised the terms ''gender identity'' and ''paraphilia''. Working with endocrinologist Claude Migeon, Money established the Johns Hopkins Gender Identity Clinic, the first clinic in the United States to perform sexual reassignment surgeries on both infants and adults. He spent a considerable amount of his career in the United States. A 1997 academic study criticised Money's work in many respects, particularly in regard to the involuntary sex-reassignment of the child David Reimer. Reimer committed suicide at 38 and his brother died of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Callon Of Epidaurus
Callon (born Callo) was an intersex person, who may have been a priestess and lived in the second century BC. The medical treatment he underwent is the first recorded example of gender affirmation surgery. His life is known from the works of Diodorus Siculus. Biography Callon was born in Epidaurus in Greece, during the second half of the second century BC. The details known about Callon's life appear in the ''Bibliotheca Historica'' written by Diodorus Siculus. Assigned female at birth, he is described by Diodorus Siculus as an orphan, who was forced to marry when he "came of age" and lived with his husband for two years. Laura Pfunter interprets Callon's age before marriage as 'pre-pubescent'. Diodorus Siculus reported he had heard that Callon was a priestess prior to his marriage. Although little is known about Callon's married life, Diodorus Siculus recorded that Callon was "not capable of natural Embraces as a Woman" and was forced "to endure those mbracesthat were preternat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diophantus Of Abae
Diophantus ( grc, Διόφαντος), born Herais ( grc, Ἡραΐς; 2nd century BC), was an intersex person who lived in the second century BC and fought as a soldier with Alexander Balas. His life is known from the works of Diodorus Siculus. Biography Diophantus was born in the city of Abae, in Arabia, during the reign of Alexander Balas. Assigned female, his birthname was Herais. His father, who was also called Diophantus, was a Macedonian Greek, and he married an Arab woman from the region. The couple's first child, a baby boy also called Diophantus, died at a young age. Diophantus Senior was perhaps a military settler in the region along with many other Macedonians. Diophantus was married to a man named Samias, who travelled abroad after they had been married for one year. Diophantus then fell ill with a fever and a tumour formed at the base of his abdomen.King, Helen (2015). Between male and female in ancient medicine. In: Boschung, Dietrich; Shapiro, Alan and Waschek, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intersex Medical Interventions
Intersex medical interventions, also known as intersex genital mutilations (IGM), are surgical, hormonal and other medical interventions performed to modify atypical or ambiguous genitalia and other sex characteristics, primarily for the purposes of making a person's appearance more typical and to reduce the likelihood of future problems. The history of intersex surgery has been characterized by controversy due to reports that surgery can compromise sexual function and sensation, and create lifelong health issues.Submission 88 to the Australian Senate inquiry on the involuntary or coerced sterilisation of people with disabilities in Australia , Australasian Paediatric Endocrine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alice Dreger
Alice Domurat Dreger () is an American historian, bioethicist, author, and former professor of clinical medical humanities and bioethics at the Feinberg School of Medicine, Northwestern University in Chicago, Illinois. Dreger engages in academic work and activism in support of individuals born with atypical sex characteristics (intersex or disorders of sex development) and individuals born as conjoined twins. She challenges the perception that those with physical differences are somehow "broken" and need to be "fixed". She has opposed the use of "corrective" surgery on babies whose genitalia are considered "ambiguous". She has criticized the failure to follow such patients in later life, and reported longer-term medical and psychological difficulties experienced by some of the people whose sex is arbitrarily assigned. She supported J. Michael Bailey in the face of controversy over his book ''The Man Who Would Be Queen''. Dreger has been criticized by transgender activist Lynn Co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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