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Posterior Commissure
The posterior commissure (also known as the epithalamic commissure) is a rounded band of white fibers crossing the middle line on the dorsal aspect of the rostral end of the cerebral aqueduct. It is important in the bilateral pupillary light reflex. Its fibers acquire their medullary sheaths early, but their connections have not been definitively determined. Most of them have their origin in a nucleus, the ''nucleus of the posterior commissure'' (nucleus of Darkschewitsch), which lies in the periaqueductal grey at rostral end of the cerebral aqueduct, in front of the oculomotor nucleus. Some are thought to be derived from the posterior part of the thalamus and from the superior colliculus, whereas others are believed to be continued downward into the medial longitudinal fasciculus. For the pupillary light reflex, the olivary pretectal nucleus In neuroanatomy, the pretectal area, or pretectum, is a midbrain structure composed of seven nuclei and comprises part of the subcort ...
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Saggital Plane
The sagittal plane (; also known as the longitudinal plane) is an anatomical plane that divides the body into right and left sections. It is perpendicular to the transverse and coronal planes. The plane may be in the center of the body and divide it into two equal parts ( mid-sagittal), or away from the midline and divide it into unequal parts (para-sagittal). The term ''sagittal'' was coined by Gerard of Cremona. Variations in terminology Examples of sagittal planes include: * The terms ''median plane'' or ''mid-sagittal plane'' are sometimes used to describe the sagittal plane running through the midline. This plane cuts the body into halves (assuming bilateral symmetry), passing through midline structures such as the navel and spine. It is one of the planes which, combined with the Umbilical plane, defines the four quadrants of the human abdomen. * The term ''parasagittal'' is used to describe any plane parallel or adjacent to a given sagittal plane. Specific named parasagi ...
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Human Brain
The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head. The cerebrum, the largest part of the human brain, consists of two cerebral hemispheres. Each hemisphere has an inner core composed of white matter, and an outer surface – the cerebral cortex – composed of grey matter. The cortex has an outer layer, the neocortex, and an inner allocortex. The neocortex is made up of six neuronal layers, while the allocortex has three or four. Each hemisphere is conventionally divided into four lobes – the frontal, temporal, parietal, and oc ...
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Human Brain
The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head. The cerebrum, the largest part of the human brain, consists of two cerebral hemispheres. Each hemisphere has an inner core composed of white matter, and an outer surface – the cerebral cortex – composed of grey matter. The cortex has an outer layer, the neocortex, and an inner allocortex. The neocortex is made up of six neuronal layers, while the allocortex has three or four. Each hemisphere is conventionally divided into four lobes – the frontal, temporal, parietal, and oc ...
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Cerebral Aqueduct
The cerebral aqueduct (aqueductus mesencephali, mesencephalic duct, sylvian aqueduct or aqueduct of Sylvius) is a conduit for cerebrospinal fluid (CSF) that connects the third ventricle to the fourth ventricle of the ventricular system of the brain. It is located in the midbrain dorsal to the pons and ventral to the cerebellum. The cerebral aqueduct is surrounded by an enclosing area of gray matter called the periaqueductal gray, or central gray. It was first named after Franciscus Sylvius. Structure Development The cerebral aqueduct, as other parts of the ventricular system of the brain, develops from the central canal of the neural tube, and it originates from the portion of the neural tube that is present in the developing mesencephalon, hence the name "mesencephalic duct." Function The cerebral aqueduct acts like a canal that passes through the midbrain. It connects the third ventricle with the fourth ventricle so that cerebrospinal fluid (CSF) moves between the ...
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Pupillary Light Reflex
The pupillary light reflex (PLR) or photopupillary reflex is a reflex that controls the diameter of the pupil, in response to the intensity (luminance) of light that falls on the retinal ganglion cells of the retina in the back of the eye, thereby assisting in adaptation of vision to various levels of lightness/darkness. A greater intensity of light causes the pupil to constrict ( miosis/myosis; thereby allowing less light in), whereas a lower intensity of light causes the pupil to dilate ( mydriasis, expansion; thereby allowing more light in). Thus, the pupillary light reflex regulates the intensity of light entering the eye. Light shone into one eye will cause both pupils to constrict. Terminology The pupil is the dark circular opening in the center of the iris and is where light enters the eye. By analogy with a camera, the pupil is equivalent to aperture, whereas the iris is equivalent to the diaphragm. It may be helpful to consider the ''Pupillary reflex'' as an Iris' ref ...
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Periaqueductal Gray
The periaqueductal gray (PAG, also known as the central gray) is a brain region that plays a critical role in autonomic function, motivated behavior and behavioural responses to threatening stimuli. PAG is also the primary control center for descending pain modulation. It has enkephalin-producing cells that suppress pain. The periaqueductal gray is the gray matter located around the cerebral aqueduct within the tegmentum of the midbrain. It projects to the nucleus raphe magnus, and also contains descending autonomic tracts. The ascending pain and temperature fibers of the spinothalamic tract send information to the PAG via the spinomesencephalic tract (so-named because the fibers originate in the spine and terminate in the PAG, in the mesencephalon or midbrain). This region has been used as the target for brain-stimulating implants in patients with chronic pain. Role in analgesia Stimulation of the periaqueductal gray matter of the midbrain activates enkephalin-releasing ...
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Oculomotor Nucleus
The fibers of the oculomotor nerve arise from a nucleus in the midbrain, which lies in the gray substance of the floor of the cerebral aqueduct and extends in front of the aqueduct for a short distance into the floor of the third ventricle. From this nucleus the fibers pass forward through the tegmentum, the red nucleus, and the medial part of the substantia nigra, forming a series of curves with a lateral convexity, and emerge from the oculomotor sulcus on the medial side of the cerebral peduncle. The nucleus of the oculomotor nerve does not consist of a continuous column of cells, but is broken up into a number of smaller nuclei, which are arranged in two groups, anterior and posterior. Those of the posterior group are six in number, five of which are symmetrical on the two sides of the middle line, while the sixth is centrally placed and is common to the nerves of both sides. The anterior group consists of two nuclei, an antero-medial and an antero-lateral. The nucleus of the o ...
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Thalamus
The thalamus (from Greek θάλαμος, "chamber") is a large mass of gray matter located in the dorsal part of the diencephalon (a division of the forebrain). Nerve fibers project out of the thalamus to the cerebral cortex in all directions, allowing hub-like exchanges of information. It has several functions, such as the relaying of sensory signals, including motor signals to the cerebral cortex and the regulation of consciousness, sleep, and alertness. Anatomically, it is a paramedian symmetrical structure of two halves (left and right), within the vertebrate brain, situated between the cerebral cortex and the midbrain. It forms during embryonic development as the main product of the diencephalon, as first recognized by the Swiss embryologist and anatomist Wilhelm His Sr. in 1893. Anatomy The thalamus is a paired structure of gray matter located in the forebrain which is superior to the midbrain, near the center of the brain, with nerve fibers projecting ...
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Superior Colliculus
In neuroanatomy, the superior colliculus () is a structure lying on the roof of the mammalian midbrain. In non-mammalian vertebrates, the homologous structure is known as the optic tectum, or optic lobe. The adjective form '' tectal'' is commonly used for both structures. In mammals, the superior colliculus forms a major component of the midbrain. It is a paired structure and together with the paired inferior colliculi forms the corpora quadrigemina. The superior colliculus is a layered structure, with a pattern that is similar to all mammals. The layers can be grouped into the superficial layers ( stratum opticum and above) and the deeper remaining layers. Neurons in the superficial layers receive direct input from the retina and respond almost exclusively to visual stimuli. Many neurons in the deeper layers also respond to other modalities, and some respond to stimuli in multiple modalities. The deeper layers also contain a population of motor-related neurons, capable of acti ...
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Medial Longitudinal Fasciculus
The medial longitudinal fasciculus (MLF) is an area of crossed over tracts, on each side of the brainstem. These bundles of axons are situated near the midline of the brainstem. They are made up of both ascending and descending fibers that arise from a number of sources and terminate in different areas, including the superior colliculus, the vestibular nuclei, and the cerebellum. It contains the interstitial nucleus of Cajal, responsible for oculomotor control, head posture, and vertical eye movement. The medial longitudinal fasciculus is the main central connection for the oculomotor nerve, trochlear nerve, and abducens nerve. It carries information about the direction that the eyes should move. Lesions of the medial longitudinal fasciculus can cause nystagmus and diplopia, which may be associated with multiple sclerosis, a neoplasm, or a stroke. Structure The medial longitudinal fasciculus is an area of crossed over tracts, on each side of the brainstem. ...
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Pretectal Area
In neuroanatomy, the pretectal area, or pretectum, is a midbrain structure composed of seven nuclei and comprises part of the subcortical visual system. Through reciprocal bilateral projections from the retina, it is involved primarily in mediating behavioral responses to acute changes in ambient light such as the pupillary light reflex, the optokinetic reflex, and temporary changes to the circadian rhythm. In addition to the pretectum's role in the visual system, the anterior pretectal nucleus has been found to mediate somatosensory and nociceptive information. Location and structure The pretectum is a bilateral group of highly interconnected nuclei located near the junction of the midbrain and forebrain. The pretectum is generally classified as a midbrain structure, although because of its proximity to the forebrain it is sometimes classified as part of the caudal diencephalon (forebrain). Within vertebrates, the pretectum is located directly anterior to the superior colliculus ...
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Edinger–Westphal Nucleus
The Edinger–Westphal nucleus (accessory oculomotor nucleus, or visceral oculomotor nucleus) is one of two nuclei of the oculomotor nerve. It is located in the midbrain. It contributes the autonomic parasympathetic (i.e. visceral) component to the oculomotor nerve, providing innervation to the iris sphincter muscle and ciliary muscle to mediate the pupillary light reflex and accommodation, respectively. It is composed of parasympathetic pre-ganglionic cell bodies that synapse in the ciliary ganglion. The term "Edinger–Westphal nucleus" also referred to what is now known as the centrally-projecting Edinger–Westphal nucleus, intermingled population of non-preganglionic neurons that do not project to the ciliary ganglion but to various regions throughout the central nervous system.. Anatomy Centrally-projecting Edinger–Westphal nucleus Alternatively, the term Edinger–Westphal nucleus is often used to refer to the adjacent population of non-preganglionic neurons that ...
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