Phase-contrast X-ray Imaging
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Phase-contrast X-ray Imaging
Phase-contrast X-ray imaging or phase-sensitive X-ray imaging is a general term for different technical methods that use information concerning changes in the phase of an X-ray beam that passes through an object in order to create its images. Standard X-ray imaging techniques like radiography or computed tomography (CT) rely on a decrease of the X-ray beam's intensity (attenuation) when traversing the sample, which can be measured directly with the assistance of an X-ray detector. However, in phase contrast X-ray imaging, the beam's phase shift caused by the sample is not measured directly, but is transformed into variations in intensity, which then can be recorded by the detector. In addition to producing projection images, phase contrast X-ray imaging, like conventional transmission, can be combined with tomographic techniques to obtain the 3D distribution of the real part of the refractive index of the sample. When applied to samples that consist of atoms with low atomic numb ...
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Wilhelm Conrad Röntgen
Wilhelm may refer to: People and fictional characters * William Charles John Pitcher, costume designer known professionally as "Wilhelm" * Wilhelm (name), a list of people and fictional characters with the given name or surname Other uses * Mount Wilhelm, the highest mountain in Papua New Guinea * Wilhelm Archipelago, Antarctica * Wilhelm (crater), a lunar crater See also * Wilhelm scream, a stock sound effect * SS ''Kaiser Wilhelm II'', or USS ''Agamemnon'', a German steam ship * Wilhelmus "Wilhelmus van Nassouwe", usually known just as "Wilhelmus" ( nl, Het Wilhelmus, italic=no; ; English translation: "The William"), is the national anthem of both the Netherlands and the Kingdom of the Netherlands. It dates back to at least 1572 ...
, the Dutch national anthem {{Disambiguation ...
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Interferometry
Interferometry is a technique which uses the ''interference'' of superimposed waves to extract information. Interferometry typically uses electromagnetic waves and is an important investigative technique in the fields of astronomy, fiber optics, engineering metrology, optical metrology, oceanography, seismology, spectroscopy (and its applications to chemistry), quantum mechanics, nuclear and particle physics, plasma physics, remote sensing, biomolecular interactions, surface profiling, microfluidics, mechanical stress/strain measurement, velocimetry, optometry, and making holograms. Interferometers are devices that extract information from interference. They are widely used in science and industry for the measurement of microscopic displacements, refractive index changes and surface irregularities. In the case with most interferometers, light from a single source is split into two beams that travel in different optical paths, which are then combined again to produce interfer ...
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Storage Ring
A storage ring is a type of circular particle accelerator in which a continuous or pulsed particle beam may be kept circulating typically for many hours. Storage of a particular particle depends upon the mass, momentum and usually the charge of the particle to be stored. Storage rings most commonly store electrons, positrons, or protons. Storage rings are most often used to store electrons that radiate synchrotron radiation. Over 50 facilities based on electron storage rings exist and are used for a variety of studies in chemistry and biology. Storage rings can also be used to produce polarized high-energy electron beams through the Sokolov-Ternov effect. The best-known application of storage rings is their use in particle accelerators and in particle colliders, where two counter-rotating beams of stored particles are brought into collision at discrete locations. The resulting subatomic interactions are then studied in a surrounding particle detector. Examples of such facilities ...
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Synchrotron
A synchrotron is a particular type of cyclic particle accelerator, descended from the cyclotron, in which the accelerating particle beam travels around a fixed closed-loop path. The magnetic field which bends the particle beam into its closed path increases with time during the accelerating process, being ''synchronized'' to the increasing kinetic energy of the particles. The synchrotron is one of the first accelerator concepts to enable the construction of large-scale facilities, since bending, beam focusing and acceleration can be separated into different components. The most powerful modern particle accelerators use versions of the synchrotron design. The largest synchrotron-type accelerator, also the largest particle accelerator in the world, is the Large Hadron Collider (LHC) near Geneva, Switzerland, built in 2008 by the European Organization for Nuclear Research (CERN). It can accelerate beams of protons to an energy of 6.5 tera electronvolts (TeV or 1012 eV). Th ...
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X-ray Tube
An X-ray tube is a vacuum tube that converts electrical input power into X-rays. The availability of this controllable source of X-rays created the field of radiography, the imaging of partly opaque objects with penetrating radiation. In contrast to other sources of ionizing radiation, X-rays are only produced as long as the X-ray tube is energized. X-ray tubes are also used in CT scanners, airport luggage scanners, X-ray crystallography, material and structure analysis, and for industrial inspection. Increasing demand for high-performance Computed tomography (CT) scanning and angiography systems has driven development of very high performance medical X-ray tubes. History X-ray tubes evolved from experimental Crookes tubes with which X-rays were first discovered on November 8, 1895, by the German physicist Wilhelm Conrad Röntgen. These first generation ''cold cathode'' or ''Crookes'' X-ray tubes were used until the 1920s. The Crookes tube was improved by William Coolidge in 19 ...
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Synchrotron Radiation
Synchrotron radiation (also known as magnetobremsstrahlung radiation) is the electromagnetic radiation emitted when relativistic charged particles are subject to an acceleration perpendicular to their velocity (). It is produced artificially in some types of particle accelerators, or naturally by fast electrons moving through magnetic fields. The radiation produced in this way has a characteristic polarization and the frequencies generated can range over a large portion of the electromagnetic spectrum. Synchrotron radiation is similar to bremsstrahlung radiation, which is emitted by a charged particle when the acceleration is parallel to the direction of motion. The general term for radiation emitted by particles in a magnetic field is ''gyromagnetic radiation'', for which synchrotron radiation is the ultra-relativistic special case. Radiation emitted by charged particles moving non-relativistically in a magnetic field is called cyclotron emission. For particles in the mildly ...
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Optical Microscopy
Optics is the branch of physics that studies the behaviour and properties of light, including its interactions with matter and the construction of instruments that use or detect it. Optics usually describes the behaviour of visible, ultraviolet, and infrared light. Because light is an electromagnetic wave, other forms of electromagnetic radiation such as X-rays, microwaves, and radio waves exhibit similar properties. Most optical phenomena can be accounted for by using the classical electromagnetic description of light. Complete electromagnetic descriptions of light are, however, often difficult to apply in practice. Practical optics is usually done using simplified models. The most common of these, geometric optics, treats light as a collection of rays that travel in straight lines and bend when they pass through or reflect from surfaces. Physical optics is a more comprehensive model of light, which includes wave effects such as diffraction and interference that cannot be ac ...
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Phase-contrast Microscopy
__NOTOC__ Phase-contrast microscopy (PCM) is an optical microscopy technique that converts phase shifts in light passing through a transparent specimen to brightness changes in the image. Phase shifts themselves are invisible, but become visible when shown as brightness variations. When light waves travel through a medium other than a vacuum, interaction with the medium causes the wave amplitude and phase to change in a manner dependent on properties of the medium. Changes in amplitude (brightness) arise from the scattering and absorption of light, which is often wavelength-dependent and may give rise to colors. Photographic equipment and the human eye are only sensitive to amplitude variations. Without special arrangements, phase changes are therefore invisible. Yet, phase changes often convey important information. Phase-contrast microscopy is particularly important in biology. It reveals many cellular structures that are invisible with a bright-field microscope, as exemplif ...
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Nobel Prize
The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfred Nobel was a Swedish chemist, engineer, and industrialist most famously known for the invention of dynamite. He died in 1896. In his will, he bequeathed all of his "remaining realisable assets" to be used to establish five prizes which became known as "Nobel Prizes." Nobel Prizes were first awarded in 1901. Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace (Nobel characterized the Peace Prize as "to the person who has done the most or best to advance fellowship among nations, the abolition or reduction of standing armies, and the establishment and promotion of peace congresses"). In 1968, Sveriges Riksbank (Sweden's central bank) funded the establishment of the Prize in Economi ...
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Diffraction Grating
In optics, a diffraction grating is an optical component with a periodic structure that diffracts light into several beams travelling in different directions (i.e., different diffraction angles). The emerging coloration is a form of structural coloration. The directions or diffraction angles of these beams depend on the wave (light) incident angle to the diffraction grating, the spacing or distance between adjacent diffracting elements (e.g., parallel slits for a transmission grating) on the grating, and the wavelength of the incident light. The grating acts as a dispersive element. Because of this, diffraction gratings are commonly used in monochromators and spectrometers, but other applications are also possible such as optical encoders for high precision motion control and wavefront measurement. For typical applications, a reflective grating has ridges or ''rulings'' on its surface while a transmissive grating has transmissive or hollow slits on its surface. Such a grating ...
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Frits Zernike
Frits Zernike (; 16 July 1888 – 10 March 1966) was a Dutch physicist and winner of the Nobel Prize in Physics in 1953 for his invention of the Phase-contrast microscopy, phase-contrast microscope. Early life and education Frits Zernike was born on 16 July 1888 in Amsterdam, Netherlands to Carl Friedrich August Zernike and Antje Dieperink. Both parents were teachers of mathematics, and he especially shared his father's passion for physics. He studied chemistry (his major), mathematics and physics at the University of Amsterdam. Academic career In 1912, he was awarded a prize for his work on opalescence in gases. In 1913, he became assistant to Jacobus Kapteyn at the astronomical laboratory of Groningen University. In 1914, Zernike and Leonard Ornstein were jointly responsible for the derivation of the Ornstein–Zernike equation in critical-point theory. In 1915, he became lector in theoretical mechanics and mathematical physics at the same university and in 1920 he was pro ...
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