Pain Wind-up

	Pain Wind-up Pain wind-up is the increase in pain intensity over time when a given stimulus is delivered repeatedly above a critical rate. It is caused by repeated stimulation of group C peripheral nerve fibers, leading to progressively increasing electrical response in the corresponding spinal cord ( posterior horn) neurons due to priming of the NMDA receptor based response.{{cite book, author1=Feng Xu, author2=Tianjian Lu, title=Introduction to Skin Biothermomechanics and Thermal Pain, url=https://books.google.com/books?id=fMggKzt8ofoC&pg=PA347, accessdate=25 April 2012, date=29 May 2011, publisher=Springer, isbn=978-3-642-13201-8, page=347Pitcher and Henry (2000). ''Eur. J. Neurosci.'', 12:2006–2020. It describes an exponentially progressive increase in firing of WDR neurons with repeated stimulation. References Pain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Pain Pain is a distressing feeling often caused by intense or damaging stimuli. The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage." In medical diagnosis, pain is regarded as a symptom of an underlying condition. Pain motivates the individual to withdraw from damaging situations, to protect a damaged body part while it heals, and to avoid similar experiences in the future. Most pain resolves once the noxious stimulus is removed and the body has healed, but it may persist despite removal of the stimulus and apparent healing of the body. Sometimes pain arises in the absence of any detectable stimulus, damage or disease. Pain is the most common reason for physician consultation in most developed countries. It is a major symptom in many medical conditions, and can interfere with a person's quality of life and general functioning. Simple ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Group C Nerve Fiber Group C nerve fibers are one of three classes of nerve fiber in the central nervous system (CNS) and peripheral nervous system (PNS). The C group fibers are unmyelinated and have a small diameter and low conduction velocity, whereas Groups A and B are myelinated. Group C fibers include postganglionic fibers in the autonomic nervous system (ANS), and nerve fibers at the dorsal roots (IV fiber). These fibers carry sensory information. Damage or injury to nerve fibers causes neuropathic pain. Capsaicin activates C fibre vanilloid receptors, giving chili peppers a hot sensation. Structure and anatomy Location C fibers are one class of nerve fiber found in the nerves of the somatic sensory system. They are afferent fibers, conveying input signals from the periphery to the central nervous system. Structure C fibers are unmyelinated unlike most other fibers in the nervous system. This lack of myelination is the cause of their slow conduction velocity, which is on the order o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Posterior Horn Of Spinal Cord The posterior grey column (posterior cornu, dorsal horn, spinal dorsal horn, posterior horn, sensory horn) of the spinal cord is one of the three grey columns of the spinal cord. It receives several types of sensory information from the body, including fine touch, proprioception, and vibration. This information is sent from receptors of the skin, bones, and joints through sensory neurons whose cell bodies lie in the dorsal root ganglion. Anatomy The posterior grey column is subdivided into six layers termed Rexed laminae I-VI Marginal nucleus of spinal cord (lamina I) Substantia gelatinosa of Rolando (lamina II) Nucleus proprius (laminae III, IV) Spinal lamina V, the neck of the posterior horn Spinal lamina VI, the base of the posterior horn. The other four Rexed laminae are located in the other two grey columns in the spinal cord. Additional images File:Gray687.png, Section of the medulla oblongata through the lower part of the decussation of the pyramids See also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]