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Prochloraz
Prochloraz, brand name Sportak, is an imidazole fungicide that was introduced in 1978 and is widely used in Europe, Australia, Asia, and South America within gardening and agriculture to control the growth of fungi. It is not registered for use in the United States. Similarly to other azole fungicides, prochloraz is an inhibitor of the enzyme lanosterol 14α-demethylase (CYP51A1), which is necessary for the production of ergosterol – an essential component of the fungal cell membrane – from lanosterol. The agent is a broad-spectrum, protective and curative fungicide, effective against ''Alternaria'' spp., '' Botrytis'' spp., ''Erysiphe'' spp., ''Helminthosporium'' spp., ''Fusarium'' spp., '' Pseudocerosporella'' spp., ''Pyrenophora'' spp., ''Rhynchosporium'' spp., and ''Septoria'' spp. Like many imidazole and triazole fungicides and antifungal medications, prochloraz is not particularly selective in its actions. In addition to inhibition of lanosterol 14α-demethylase, proch ...
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Imidazole
Imidazole (ImH) is an organic compound with the formula C3N2H4. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. In chemistry, it is an aromatic heterocycle, classified as a diazole Diazole refers to either one of a pair of isomeric chemical compounds with molecular formula C3H4N2, having a five-membered ring consisting of three carbon atoms and two nitrogen atoms.
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Lanosterol
Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungal steroids are derived. By contrast plant steroids are produced via cycloartenol. Role in biosynthesis of other steroids Elaboration of lanosterol under enzyme catalysis leads to the core structure of steroids. 14-Demethylation of lanosterol by CYP51 eventually yields cholesterol. Biosynthesis Research Lanosterol has been identified as a key component in maintaining eye lens clarity. Pre-clinical research has identified Lanosterol as a possible agent for the reversal and prevention of cataracts. In vivo experiments on dogs showed significant reversal of cataracts within 6 weeks of lanosterol injection. In 2018, Lanosterol was shown to improve lens clarity in cells with lens clouding due to aging or physical stressors. A subsequent study found positive results on the optics of the lens in mice with cataracts (Wang, Hoshino,Uesugi, Yagi, Pierscionek and Andley (2022). Use Lanosterol is a ...
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Receptor Antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist drugs interfere in the natural operation of receptor proteins.Pharmacology Guide: In vitro pharmacology: concentration-response curves
" '' GlaxoWellcome.'' Retrieved on December 6, 2007.
They are sometimes called blockers; examples include alpha blockers,

Antifungal
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. Such drugs are usually yes obtained by a doctor's prescription, but a few are available over the counter (OTC). Types of antifungal There are two types of antifungals: local and systemic. Local antifungals are usually administered topically or vaginally, depending on the condition being treated. Systemic antifungals are administered orally or intravenously. Of the clinically employed azole antifungals, only a handful are used systemically. These include ketoconazole, itraconazole, fluconazole, fosfluconazole, voriconazole, posaconazole, and isavuconazole. Examples of non-azole systemic antifungals include griseofulvin and terbinafine. Classes Polyenes A polyene is a molecule with multiple conjugated do ...
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Triazole
A triazole is a heterocyclic compound featuring a five-membered ring of two carbon atoms and three nitrogen atoms with molecular formula C2H3N3. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Lastly, the many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Isomerism There are four triazole isomers, which are conventionally divided into two pairs of tautomers. In the 1,2,3-triazoles, the three nitrogen atoms are adjacent; in the 1,2,4-triazoles, an interstitial carbon separates out one nitrogen atom. Each category has two tautomers that differ by which nitrogen has a hydrogen bonded ...
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Septoria
''Septoria'' are ascomycete pycnidia-producing fungi that cause numerous leaf spot diseases on field crops, forages and many vegetables including tomatoes which are known to contract ''Septoria musiva'' from nearby cottonwood trees, and is responsible for yield losses. The genus is widespread, and estimated to contain 1072 species. Pycnidia produce needle-like pycnidiospores. ''Septoria apiicola'' is the cause of late blight of celery. It is characterized by the production of conidia within pycnidia. The symptoms include chlorotic spots that turn brown and necrotic. ''Septoria apiicola'' can survive on seeds. Several species of passion flower are infected by several species of ''Septoria'', and a fungus, which has been going by the name ''Septoria passiflorae'' but which is probably an undescribed species, has been used to control the invasive ''Passiflora tarminiana ''Passiflora tarminiana'' (or banana passionfruit) is a species of passionfruit. The yellow fruits are edi ...
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Rhynchosporium
''Rhynchosporium'' is a genus of fungi that causes leaf scald disease on several graminaceous hosts. It includes five currently accepted species: '' R. secalis'' from rye and triticale, '' R. orthosporum'' from ''Dactylis glomerata'', '' R. lolii'' from ''Lolium multiflorum'' and '' L. perenne'', '' R. agropyri'' from ''Agropyron'', and '' R. commune'' from ''Hordeum'' spp., ''Lolium multiflorum'' and ''Bromus diandrus ''Bromus diandrus'' is a species of grass known by the common names great brome and "ripgut brome". Description This is a brome grass which is native to the Mediterranean but has been introduced to much of the rest of the world. It does best in ...''. ''R. commune'' is one of the most destructive pathogens of barley worldwide, causing yield decreases of up to 40% and reduced grain quality.
Pla ...
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Pyrenophora
The fungal genus ''Pyrenophora'' includes 191 species, including the following plant pathogenic species: '' P. teres'', '' P. graminea'' and '' P. tritici-repentis''. ''P. teres'' (teleomorph ''Drechslera teres'') makes up to 3 conidia per conidiophore. It infects plants with an appressorium. It grows biotrophically in the first infected plant cell, but then switches to a necrotrophic growth mode. During necrotrophic growth the fungus can only be found in the plant apoplast Inside a plant, the apoplast can mean the space outside of cell membranes, where material can diffuse freely; that is, the extracellular spaces. ''Apoplast '' can also refer especially to the continuum of cell walls of adjacent cells; fluid and ma ... but not within plant cells. References Fungal plant pathogens and diseases Pleosporaceae {{fungus-plant-disease-stub ...
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Fusarium
''Fusarium'' is a large genus of filamentous fungi, part of a group often referred to as hyphomycetes, widely distributed in soil and associated with plants. Most species are harmless saprobes, and are relatively abundant members of the soil microbial community. Some species produce mycotoxins in cereal crops that can affect human and animal health if they enter the food chain. The main toxins produced by these ''Fusarium'' species are fumonisins and trichothecenes. Despite most species apparently being harmless (some existing on the skin as commensal members of the skin flora), some ''Fusarium'' species and subspecific groups are among the most important fungal pathogens of plants and animals. The name of ''Fusarium'' comes from Latin ''fusus'', meaning a spindle. Taxonomy The taxonomy of the genus is complex. A number of different schemes have been used, and up to 1,000 species have been identified at times, with approaches varying between wide and narrow concepts of speci ...
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Helminthosporium
''Helminthosporium'' is a genus of fungi belonging to the family Massarinaceae. The genus has cosmopolitan distribution In biogeography, cosmopolitan distribution is the term for the range of a taxon that extends across all or most of the world in appropriate habitats. Such a taxon, usually a species, is said to exhibit cosmopolitanism or cosmopolitism. The ext .... Species Species: *'' Helminthosporium abietis'' *'' Helminthosporium abutilonis'' *'' Helminthosporium acaciae'' References {{Taxonbar, from=Q3129938 Fungus genera Pleosporales ...
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Erysiphe
''Erysiphe'' is a genus of fungi in the family Erysiphaceae. Many of the species in this genus are plant pathogens which cause powdery mildew. Species This genus includes, but is not limited to the following species: * ''Erysiphe alphitoides'' * '' Erysiphe azerbaijanica'' * ''Erysiphe betae'' * '' Erysiphe brunneopunctata'' * ''Erysiphe cichoracearum'' * '' Erysiphe communis'' * ''Erysiphe cruciferarum'' * ''Erysiphe fernandoae'' * '' Erysiphe flexuosa'' * ''Erysiphe heraclei'' * ''Erysiphe lespedezae'' 1. Xiao, Y.-T., C.-J. Wang, T.-C. Huang, and Y.-M. Shen. 2020. Erysiphe lespedezae causing powdery mildew on Bauhinia variegata, B. blakeana and Desmodium caudatum in Taiwan. Forest Pathology 50(5):e12631. * ''Erysiphe michikoae'' * ''Erysiphe nitida * ''Erysiphe pisi'' * ''Erysiphe polygoni'' * ''Erysiphe robiniae'' * ''Erysiphe syringae'' Former species * ''Blumeria graminis'' * ''Uncinula necator ''Uncinula necator'' (syn. ''Erysiphe necator'') is a fungus that causes pow ...
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