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Phosphocreatine
Phosphocreatine, also known as creatine phosphate (CP) or PCr (Pcr), is a phosphorylated form of creatine that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle, myocardium and the brain to recycle adenosine triphosphate, the energy currency of the cell. Chemistry In the kidneys, the enzyme AGAT catalyzes the conversion of two amino acids — arginine and glycine — into guanidinoacetate (also called glycocyamine or GAA), which is then transported in the blood to the liver. A methyl group is added to GAA from the amino acid methionine by the enzyme GAMT, forming non-phosphorylated creatine. This is then released into the blood by the liver where it travels mainly to the muscle cells (95% of the body's creatine is in muscles), and to a lesser extent the brain, heart, and pancreas. Once inside the cells it is transformed into phosphocreatine by the enzyme complex creatine kinase. Phosphocreatine is able to donate its phosphate group to convert ad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Creatine
Creatine ( or ) is an organic compound with the nominal formula (H2N)(HN)CN(CH3)CH2CO2H. It exists in various modifications (tautomers) in solution. Creatine is found in vertebrates where it facilitates recycling of adenosine triphosphate (ATP), primarily in muscle and brain tissue. Recycling is achieved by converting adenosine diphosphate (ADP) back to ATP via donation of phosphate groups. Creatine also acts as a buffer. History Creatine was first identified in 1832 when Michel Eugène Chevreul isolated it from the basified water-extract of skeletal muscle. He later named the crystallized precipitate after the Greek word for meat, κρέας (''kreas''). In 1928, creatine was shown to exist in equilibrium with creatinine. Studies in the 1920s showed that consumption of large amounts of creatine did not result in its excretion. This result pointed to the ability of the body to store creatine, which in turn suggested its use as a dietary supplement. In 1912, Harvard Univer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adenosine Triphosphate
Adenosine triphosphate (ATP) is an organic compound that provides energy to drive many processes in living cells, such as muscle contraction, nerve impulse propagation, condensate dissolution, and chemical synthesis. Found in all known forms of life, ATP is often referred to as the "molecular unit of currency" of intracellular energy transfer. When consumed in metabolic processes, it converts either to adenosine diphosphate (ADP) or to adenosine monophosphate (AMP). Other processes regenerate ATP. The human body recycles its own body weight equivalent in ATP each day. It is also a precursor to DNA and RNA, and is used as a coenzyme. From the perspective of biochemistry, ATP is classified as a nucleoside triphosphate, which indicates that it consists of three components: a nitrogenous base (adenine), the sugar ribose, and the Polyphosphate, triphosphate. Structure ATP consists of an adenine attached by the 9-nitrogen atom to the 1′ carbon atom of a sugar (ribose), which i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adenosine Triphosphate
Adenosine triphosphate (ATP) is an organic compound that provides energy to drive many processes in living cells, such as muscle contraction, nerve impulse propagation, condensate dissolution, and chemical synthesis. Found in all known forms of life, ATP is often referred to as the "molecular unit of currency" of intracellular energy transfer. When consumed in metabolic processes, it converts either to adenosine diphosphate (ADP) or to adenosine monophosphate (AMP). Other processes regenerate ATP. The human body recycles its own body weight equivalent in ATP each day. It is also a precursor to DNA and RNA, and is used as a coenzyme. From the perspective of biochemistry, ATP is classified as a nucleoside triphosphate, which indicates that it consists of three components: a nitrogenous base (adenine), the sugar ribose, and the Polyphosphate, triphosphate. Structure ATP consists of an adenine attached by the 9-nitrogen atom to the 1′ carbon atom of a sugar (ribose), which i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosphorylation
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License. Protein phosphorylation often activates (or deactivates) many enzymes. Glucose Phosphorylation of sugars is often the first stage in their catabolism. Phosphorylation allows cells to accumulate sugars because the phosphate group prevents the molecules from diffusing back across their transporter. Phosphorylation of glucose is a key reaction in sugar metabolism. The chemical equation for the conversion of D-glucose to D-glucose-6-phosphate in the first step of glycolysis is given by :D-glucose + ATP → D-glucose-6-phosphate + ADP : ΔG° = −16.7 kJ/mol (° indicates measurement at standard condition) Hepatic cells are freely permeable to glucose, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carboxylic Acids
In organic chemistry, a carboxylic acid is an organic acid that contains a carboxyl group () attached to an R-group. The general formula of a carboxylic acid is or , with R referring to the alkyl, alkenyl, aryl, or other group. Carboxylic acids occur widely. Important examples include the amino acids and fatty acids. Deprotonation of a carboxylic acid gives a carboxylate anion. Examples and nomenclature Carboxylic acids are commonly identified by their trivial names. They at oftentimes have the suffix ''-ic acid''. IUPAC-recommended names also exist; in this system, carboxylic acids have an ''-oic acid'' suffix. For example, butyric acid (C3H7CO2H) is butanoic acid by IUPAC guidelines. For nomenclature of complex molecules containing a carboxylic acid, the carboxyl can be considered position one of the parent chain even if there are other substituents, such as 3-chloropropanoic acid. Alternately, it can be named as a "carboxy" or "carboxylic acid" substituent on another ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Alberta
The University of Alberta, also known as U of A or UAlberta, is a public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford,"A Gentleman of Strathcona – Alexander Cameron Rutherford", Douglas R. Babcock, 1989, The University of Calgary Press, 2500 University Drive NW, Calgary, Alberta, Canada, the first premier of Alberta, and Henry Marshall Tory,"Henry Marshall Tory, A Biography", originally published 1954, current edition January 1992, E.A. Corbett, Toronto: Ryerson Press, the university's first president. It was enabled through the Post-secondary Learning Act''.'' The university is considered a "comprehensive academic and research university" (CARU), which means that it offers a range of academic and professional programs that generally lead to undergraduate and graduate level credentials. The university comprises four campuses in Edmonton, an Augustana Campus in Camrose, and a staff centre in downtown Cal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kaiser Wilhelm Institute
The Kaiser Wilhelm Society for the Advancement of Science (German: ''Kaiser-Wilhelm-Gesellschaft zur Förderung der Wissenschaften'') was a German scientific institution established in the German Empire in 1911. Its functions were taken over by the Max Planck Society. The Kaiser Wilhelm Society was an umbrella organisation for many institutes, testing stations, and research units created under its authority. Constitution The Kaiser Wilhelm Gesellschaft (KWG) was founded in 1911 in order to promote the natural sciences in Germany, by founding and maintaining research institutions formally independent from the state and its administrations. The institutions were to be under the guidance of prominent directors, which included the physicists and chemists Walther Bothe, Peter Debye, Albert Einstein, Fritz Haber and Otto Hahn; a board of trustees also provided guidance. Funding was ultimately obtained from sources internal and external to Germany. Internally, money was raised from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Otto Fritz Meyerhof
Otto Fritz Meyerhof (; April 12, 1884 – October 6, 1951) was a German physician and biochemist who won the 1922 Nobel Prize in Physiology and Medicine. Biography Otto Fritz Meyerhof was born in Hannover, at Theaterplatz 16A (now:Rathenaustrasse 16A), the son of wealthy Jewish parents. In 1888, his family moved to Berlin, where Otto spent most of his childhood, and where he started his study of medicine. He continued these studies in Strasbourg and Heidelberg, from which he graduated in 1909, with a work titled "Contributions to the Psychological Theory of Mental Illness". In Heidelberg, he met Hedwig Schallenberg. They married in 1914 and became parents of a daughter, Bettina, and two sons, Gottfried (who referred, after emigration, to himself as Geoffrey) as well as Walter. In 1912, Otto Meyerhof moved to the University of Kiel, where he received a professorship in 1918. In 1922, he was awarded the Nobel Prize in Medicine, with Archibald Vivian Hill, for his work on muscle me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Nachmansohn
David Nachmansohn (17 March 1899 – 2 November 1983) was a German-Jewish biochemist responsible for elucidating the role of phosphocreatine in energy production in the muscles, and the role of the neurotransmitter acetylcholine in nerve stimulation. He is also recognised for his basic research into the biochemistry and mechanism underlying bioelectric phenomena. Early life and education He was born in Ekaterinoslav, Russia (now Dnipro, Ukraine), moving to Berlin at an early age. In 1926 he went to the Kaiser-Wilhelm Institut für Biologie where he worked in the laboratory under Otto Meyerhof. Nachmansohn discovered that rapidly contracting muscles contained more phosphocreatine than slowly contracting ones, which eventually led to the hypothesis that phosphocreatine was involved in the regeneration of the ATP that was built up to provide energy during muscular contraction. Exile and research career Leaving Nazi-era Berlin, Nachmansohn arrived in Paris in 1933 and took up a pos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Medical School
Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consistently ranked first for research among medical schools by '' U.S. News & World Report''. Unlike most other leading medical schools, HMS does not operate in conjunction with a single hospital but is directly affiliated with several teaching hospitals in the Boston area. Affiliated teaching hospitals and research institutes include Dana–Farber Cancer Institute, Massachusetts General Hospital, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Boston Children's Hospital, McLean Hospital, Cambridge Health Alliance, The Baker Center for Children and Families, and Spaulding Rehabilitation Hospital. History Harvard Medical School was founded on September 19, 1782, after President Joseph Willard presented a report with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yellapragada Subbarow
Yellapragada Subba Rao (12 January 1895 – 8 August 1948) was a pioneering Indian biochemist who discovered the function of adenosine triphosphate (ATP) as an energy source in the cell, developed methotrexate for the treatment of cancer and led the department at Lederle laboratories in which Benjamin Minge Duggar discovered chlortetracycline (Aureomycin) in 1945. A student of Madras Medical College, his elder brother and younger brother both died due to tropical sprue in the span of 8 days. He subsequently discovered folic acid as a cure for tropical sprue. He discovered methotrexate, a chemotherapy drug still used today and also used for rheumatoid arthritis, and diethylcarbamazine (DEC), the only effective drug for treating filariasis. Most of his career was spent in the United States. Despite his isolation of ATP, Subbarao did not gain tenure at Harvard though he would lead some of America's most important medical research during World War II. He is also credited with t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyrus Fiske
Cyrus (Persian: کوروش) is a male given name. It is the given name of a number of Persian kings. Most notably it refers to Cyrus the Great ( BC). Cyrus is also the name of Cyrus I of Anshan ( BC), King of Persia and the grandfather of Cyrus the Great; and Cyrus the Younger (died 401 BC), brother to the Persian King Artaxerxes II of Persia. Etymology Cyrus, as a word in English, is the Latinized form of the Greek Κῦρος, ''Kȳros'', from Old Persian ''Kūruš''. According to the inscriptions the name is reflected in Elamite ''Kuraš'', Babylonian ''Ku(r)-raš/-ra-áš'' and Imperial Aramaic ''kwrš''. The modern Persian form of the name is '' Kūroš''. The etymology of Cyrus has been and continues to be a topic of discussion amongst historians, linguists, and scholars of Iranology. The Old Persian name "kuruš" has been interpreted in various forms such as "the Sun", "like Sun", "young", "hero," and "humiliator of the enemy in verbal contest" and the Elamite "kura ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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