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Patch Clamp
The patch clamp technique is a laboratory technique in electrophysiology used to study ionic currents in individual isolated living cells, tissue sections, or patches of cell membrane. The technique is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers, and pancreatic beta cells, and can also be applied to the study of bacterial ion channels in specially prepared giant spheroplasts. Patch clamping can be performed using the voltage clamp technique. In this case, the voltage across the cell membrane is controlled by the experimenter and the resulting currents are recorded. Alternatively, the current clamp technique can be used. In this case, the current passing across the membrane is controlled by the experimenter and the resulting changes in voltage are recorded, generally in the form of action potentials. Erwin Neher and Bert Sakmann developed the patch clamp in the late 1970s and early 1980s. This discovery made it possible to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Physiology Or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace. The Nobel Prize is presented annually on the anniversary of Alfred Nobel's death, 10 December. As of 2022, 114 Nobel Prizes in Physiology or Medicine have been awarded to 226 laureates, 214 men and 12 women. The first one was awarded in 1901 to the German physiologist, Emil von Behring, for his work on serum therapy and the development of a vaccine against diphtheria. The first woman to receive the Nobel Prize in Physiology or Medicine, Gerty Cori, received it in 1947 for her role in elucidati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ohm (unit)
Ohm (symbol Ω) is a unit of electrical resistance named after Georg Ohm. Ohm or OHM may also refer to: People * Georg Ohm (1789–1854), German physicist and namesake of the term ''ohm'' * Germán Ohm (born 1936), Mexican boxer * Jörg Ohm (born 1944), former East German football player * Martin Ohm (1792–1872), German mathematician * Rebecca Ohm, United States Air Force officer and fighter pilot * Rune Ohm (born 1980), Danish handball player * Thorsten Ohm, CEO of VDM Publishing * Pawat Chittsawangdee, Thai actor, nicknamed Ohm Places Germany * Ohm (river), right tributary of the Lahn near Cölbe * Zwester Ohm, left tributary of the Lahn near Fronhausen Outer space * 24750 Ohm, an outer main belt asteroid * Ohm (crater) on the Moon Science and technology * Acoustic ohm, a unit of measurement of acoustic impedance * Ohm's law, law that relates electrical resistance, current, and voltage * OHM (Observe. Hack. Make.), a 2013 outdoor hacker conference * OpenHistoricalMap, a c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Omega
Omega (; capital: Ω, lowercase: ω; Ancient Greek ὦ, later ὦ μέγα, Modern Greek ωμέγα) is the twenty-fourth and final letter in the Greek alphabet. In the Greek numeric system/isopsephy (gematria), it has a value of 800. The word literally means "great O" (''ō mega'', mega meaning "great"), as opposed to omicron, which means "little O" (''o mikron'', micron meaning "little"). In phonetic terms, the Ancient Greek Ω represented a long open-mid back rounded vowel , comparable to the "aw" of the English word ''raw'' in dialects without the cot–caught merger, in contrast to omicron which represented the close-mid back rounded vowel , and the digraph ''ου'' which represented the long close-mid back rounded vowel . In Modern Greek, both omega and omicron represent the mid back rounded vowel or . The letter omega is transliterated into a Latin-script alphabet as ''ō'' or simply ''o''. As the final letter in the Greek alphabet, omega is often used t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrical Resistance
The electrical resistance of an object is a measure of its opposition to the flow of electric current. Its reciprocal quantity is , measuring the ease with which an electric current passes. Electrical resistance shares some conceptual parallels with mechanical friction. The SI unit of electrical resistance is the ohm (), while electrical conductance is measured in siemens (S) (formerly called the 'mho' and then represented by ). The resistance of an object depends in large part on the material it is made of. Objects made of electrical insulators like rubber tend to have very high resistance and low conductance, while objects made of electrical conductors like metals tend to have very low resistance and high conductance. This relationship is quantified by resistivity or conductivity. The nature of a material is not the only factor in resistance and conductance, however; it also depends on the size and shape of an object because these properties are extensive rather than intens ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patch Clamp Schematic 2
Patch or Patches may refer to: Arts, entertainment and media * Patch Johnson, a fictional character from ''Days of Our Lives'' * Patch (''My Little Pony''), a toy * "Patches" (Dickey Lee song), 1962 * "Patches" (Chairmen of the Board song), 1970, also covered by Clarence Carter * Patch (website), an online news service * "Patches", a song by Dala from the album ''Angels & Thieves'' People * Patch Adams (Hunter Adams, born 1945), American physician and clown * Alexander Patch (1889–1945), WWII U.S. Army general * Harry Patch (1898–2009), WWI British veteran * Horace Patch (1814–1862), American politician Places * Patch, St. Louis, Missouri, U.S. * Patch, Gwbert, Ceredigion, Wales Science and technology Computing * Patch (computing), changes to a computer program * patch (Unix), a UNIX utility * PATCH (HTTP), an HTTP request to make a change Electronics * Autopatch or phone patch, from radio to telephone * Patch antenna * Patch cable, to connect devices * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Membrane
The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of all cells from the outside environment (the extracellular space). The cell membrane consists of a lipid bilayer, made up of two layers of phospholipids with cholesterols (a lipid component) interspersed between them, maintaining appropriate membrane fluidity at various temperatures. The membrane also contains membrane proteins, including integral proteins that span the membrane and serve as membrane transporters, and peripheral proteins that loosely attach to the outer (peripheral) side of the cell membrane, acting as enzymes to facilitate interaction with the cell's environment. Glycolipids embedded in the outer lipid layer serve a similar purpose. The cell membrane controls the movement of substances in and out of cells and organelles, being selectively permeable to ions a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Micrometre
The micrometre ( international spelling as used by the International Bureau of Weights and Measures; SI symbol: μm) or micrometer (American spelling), also commonly known as a micron, is a unit of length in the International System of Units (SI) equalling (SI standard prefix "micro-" = ); that is, one millionth of a metre (or one thousandth of a millimetre, , or about ). The nearest smaller common SI unit is the nanometre, equivalent to one thousandth of a micrometre, one millionth of a millimetre or one billionth of a metre (). The micrometre is a common unit of measurement for wavelengths of infrared radiation as well as sizes of biological cells and bacteria, and for grading wool by the diameter of the fibres. The width of a single human hair ranges from approximately 20 to . The longest human chromosome, chromosome 1, is approximately in length. Examples Between 1 μm and 10 μm: * 1–10 μm – length of a typical bacterium * 3–8 μm – width of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytoplasm
In cell biology, the cytoplasm is all of the material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus. The material inside the nucleus and contained within the nuclear membrane is termed the nucleoplasm. The main components of the cytoplasm are cytosol (a gel-like substance), the organelles (the cell's internal sub-structures), and various cytoplasmic inclusions. The cytoplasm is about 80% water and is usually colorless. The submicroscopic ground cell substance or cytoplasmic matrix which remains after exclusion of the cell organelles and particles is groundplasm. It is the hyaloplasm of light microscopy, a highly complex, polyphasic system in which all resolvable cytoplasmic elements are suspended, including the larger organelles such as the ribosomes, mitochondria, the plant plastids, lipid droplets, and vacuoles. Most cellular activities take place within the cytoplasm, such as many metabolic pathways including glycolysis, and proces ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patch Clamp Schematic 1
Patch or Patches may refer to: Arts, entertainment and media * Patch Johnson, a fictional character from ''Days of Our Lives'' * Patch (''My Little Pony''), a toy * "Patches" (Dickey Lee song), 1962 * "Patches" (Chairmen of the Board song), 1970, also covered by Clarence Carter * Patch (website), an online news service * "Patches", a song by Dala from the album ''Angels & Thieves'' People * Patch Adams (Hunter Adams, born 1945), American physician and clown * Alexander Patch (1889–1945), WWII U.S. Army general * Harry Patch (1898–2009), WWI British veteran * Horace Patch (1814–1862), American politician Places * Patch, St. Louis, Missouri, U.S. * Patch, Gwbert, Ceredigion, Wales Science and technology Computing * Patch (computing), changes to a computer program * patch (Unix), a UNIX utility * PATCH (HTTP), an HTTP request to make a change Electronics * Autopatch or phone patch, from radio to telephone * Patch antenna * Patch cable, to connect devices * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pipette Puller-en
A pipette (sometimes spelled as pipett) is a laboratory tool commonly used in chemistry, biology and medicine to transport a measured volume of liquid, often as a media dispenser. Pipettes come in several designs for various purposes with differing levels of accuracy and precision, from single piece glass pipettes to more complex adjustable or electronic pipettes. Many pipette types work by creating a partial vacuum above the liquid-holding chamber and selectively releasing this vacuum to draw up and dispense liquid. Measurement accuracy varies greatly depending on the instrument. History The first simple pipettes were made in glass, such as Pasteur pipettes. Large pipettes continue to be made in glass; others are made in squeezable plastic for situations where an exact volume is not required. The first micropipette was patented in 1957 by Dr Heinrich Schnitger (Marburg, Germany). The founder of the company Eppendorf, Dr. Heinrich Netheler, inherited the rights and started the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ground (electricity)
In electrical engineering, ground or earth is a reference point in an electrical circuit from which voltages are measured, a common return path for electric current, or a direct physical connection to the Earth. Electrical circuits may be connected to ground for several reasons. Exposed conductive parts of electrical equipment are connected to ground, to protect users from electrical shock hazard. If internal insulation fails, dangerous voltages may appear on the exposed conductive parts. Connecting exposed parts to ground will allow circuit breakers (or RCDs) to interrupt power supply in the event of a fault. In electric power distribution systems, a protective earth (PE) conductor is an essential part of the safety provided by the earthing system. Connection to ground also limits the build-up of static electricity when handling flammable products or electrostatic-sensitive devices. In some telegraph and power transmission circuits, the ground itself can be used as one condu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
