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Oskar (gene)
''oskar'' is a gene required for the development of the ''Drosophila'' embryo. It defines the posterior pole during early embryogenesis. Its two isoforms, short and long, play different roles in Drosophila embryonic development. ''oskar'' was named after the main character from the Günter Grass novel The Tin Drum, who refuses to grow up. Evolutionary history ''oskar'' displays a unique evolutionary origin resulting from a Horizontal Domain Transfer from a probably bacterial endosymbiont onto an ancestral insect genome. The OSK domain is of bacterial origin and fused with the LOTUS domain through a linker domain. This event must have happened just prior to the divergence with the Crustacean, the insect's sister group, as ''oskar'' can be found as early as the Zygentoma but does not seem to exist in Crustacean. Translational-level regulation ''oskar'' is translationally repressed prior to reaching the posterior pole of the oocyte by Bruno, which binds to three bruno res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cup (protein)
A cup is an open-top used to hold hot or cold liquids for pouring or drinking; while mainly used for drinking, it also can be used to store solids for pouring (e.g., sugar, flour, grains, salt). Cups may be made of glass, metal, china, clay, wood, stone, polystyrene, plastic, aluminium or other materials, and are usually fixed with a stem, handles, or other adornments. Cups are used for quenching thirst across a wide range of cultures and social classes, and different styles of cups may be used for different liquids or in different situations. Cups of different styles may be used for different types of liquids or other foodstuffs (e.g. teacups and measuring cups), in different situations (e.g. at water stations or in ceremonies and rituals), or for decoration. Rigby 2003: p. 573–574. History Cups are an improvement on using cupped hands or feet to hold liquids. They have almost certainly been used since before recorded history, and have been found at archaeological site ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vasa Gene
''Vasa'' is an RNA binding protein with an ATP-dependent RNA helicase that is a member of the DEAD box family of proteins. The vasa gene is essential for germ cell development and was first identified in ''Drosophila melanogaster'', but has since been found to be conserved in a variety of vertebrates and invertebrates including humans. The Vasa protein is found primarily in germ cells in embryos and adults, where it is involved in germ cell determination and function, as well as in multipotent stem cells, where its exact function is unknown. Gene The Vasa gene is a member of the DEAD box family of RNA helicases in ''Drosophila melanogaster.'' Its human ortholog, Ddx4, is located on human chromosome 5q. It is syntenic to mouse chromosome 13, where the mouse vasa gene is located. The gene is conserved in many invertebrates and vertebrate species such as ''Caenorhabditis elegans'', ''Xenopus'', Zebrafish, flatworms, echinoderms, molluscs, nematodes, mice and rats as an important par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TDRD7
Tudor domain-containing protein 7 is a protein that in humans is encoded by the ''TDRD7'' gene. In melanocytic cells TDRD7 gene expression may be regulated by MITF. Gene polymorphism Various single nucleotide polymorphisms (SNPs) of the TDRD7 gene have been identified and for some of them an association with lower susceptibility to age-related cataract was shown. Interactions TDRD7 has been shown to interact with TACC1 Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the ''TACC1'' gene. Function The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer .... References Further reading * * * * * * External links * * {{gene-9-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Helix-turn-helix
Helix-turn-helix is a DNA-binding protein (DBP). The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates two α helices, joined by a short strand of amino acids, that bind to the major groove of DNA. The HTH motif occurs in many proteins that regulate gene expression. It should not be confused with the helix–loop–helix motif. Discovery The discovery of the helix-turn-helix motif was based on similarities between several genes encoding transcription regulatory proteins from bacteriophage lambda and ''Escherichia coli'': Cro, CAP, and λ repressor, which were found to share a common 20–25 amino acid sequence that facilitates DNA recognition. Function The helix-turn-helix motif is a DNA-binding motif. The recognition and binding to DNA by helix-turn-helix proteins is done by the two α helices, one occupying the N-terminal end of the motif, the other at the C-terminus. In most cases, such as in the Cro repressor, the second ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pseudoenzyme
Pseudoenzymes are variants of enzymes (usually proteins) that are catalytically-deficient (usually inactive), meaning that they perform little or no enzyme catalysis. They are believed to be represented in all major enzyme families in the kingdoms of life, where they have important signaling and metabolic functions, many of which are only now coming to light. Pseudoenzymes are becoming increasingly important to analyse, especially as the bioinformatic analysis of genomes reveals their ubiquity. Their important regulatory and sometimes disease-associated functions in metabolic and signalling pathways are also shedding new light on the non-catalytic functions of active enzymes, of moonlighting proteins, the re-purposing of proteins in distinct cellular roles (Protein moonlighting). They are also suggesting new ways to target and interpret cellular signalling mechanisms using small molecules and drugs. The most intensively analyzed, and certainly the best understood pseudoenzymes in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA-binding Protein
RNA-binding proteins (often abbreviated as RBPs) are proteins that bind to the double or single stranded RNA in cells and participate in forming ribonucleoprotein complexes. RBPs contain various structural motifs, such as RNA recognition motif (RRM), dsRNA binding domain, zinc finger and others. They are cytoplasmic and nuclear proteins. However, since most mature RNA is exported from the nucleus relatively quickly, most RBPs in the nucleus exist as complexes of protein and pre-mRNA called heterogeneous ribonucleoprotein particles (hnRNPs). RBPs have crucial roles in various cellular processes such as: cellular function, transport and localization. They especially play a major role in post-transcriptional control of RNAs, such as: splicing, polyadenylation, mRNA stabilization, mRNA localization and translation. Eukaryotic cells express diverse RBPs with unique RNA-binding activity and protein–protein interaction. According to the Eukaryotic RBP Database (EuRBPDB), there are 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ribosome
Ribosomes ( ) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins). The ribosomes and associated molecules are also known as the ''translational apparatus''. Overview The sequence of DNA that encodes the sequence of the amino acids in a protein is transcribed into a messenger RNA chain. Ribosomes bind to messenger RNAs and use their sequences for determining the correct sequence of amino acids to generate a given protein. Amino acids are selected and carried to the ribosome by transfer RNA (tRNA) molecules, which enter the ribosome and bind to the messenger RNA chain via an anti-c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barentsz (protein)
Willem Barentsz (; – 20 June 1597), anglicized as William Barents or Barentz, was a Dutch navigator, cartographer, and Arctic explorer. Barentsz went on three expeditions to the far north in search for a Northeast passage. He reached as far as Novaya Zemlya and the Kara Sea in his first two voyages, but was turned back on both occasions by ice. During a third expedition, the crew discovered Spitsbergen and Bear Island, but subsequently became stranded on Novaya Zemlya for almost a year. Barentsz died on the return voyage in 1597. The Barents Sea, among many other places, is named after him. Life and career Willem Barentsz was born around 1550 in the village Formerum on the island Terschelling in the Seventeen Provinces, present-day Netherlands. ''Barentsz'' was not his surname but rather his patronymic name, short for ''Barentszoon'' " Barent's son". A cartographer by trade, Barentsz sailed to Spain and the Mediterranean to complete an atlas of the Mediterranean regi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EIF4E
Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the ''EIF4E'' gene. Structure and function Most eukaryotic cellular mRNAs are blocked at their 5'-ends with the 7-methyl-guanosine five-prime cap structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. eIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of the eIF4F pre-initiation complex. Almost all cellular mRNA require eIF4E in order to be translated into protein. The eIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of eIF4F are a 47-kD polypeptide, terme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bruno Response Elements
Bruno may refer to: People and fictional characters *Bruno (name), including lists of people and fictional characters with either the given name or surname * Bruno, Duke of Saxony (died 880) * Bruno the Great (925–965), Archbishop of Cologne, Duke of Lotharingia and saint * Bruno (bishop of Verden) (920–976), German Roman Catholic bishop * Pope Gregory V (c. 972–999), born Bruno of Carinthia * Bruno of Querfurt (c. 974–1009), Christian missionary bishop, martyr and saint * Bruno of Augsburg (c. 992–1029), Bishop of Augsburg * Bruno (bishop of Würzburg) (1005–1045), German Roman Catholic bishop * Pope Leo IX (1002–1054), born Bruno of Egisheim-Dagsburg * Bruno II (1024–1057), Frisian count or margrave * Bruno the Saxon (fl. 2nd half of the 11th century), historian * Saint Bruno of Cologne (d. 1101), founder of the Carthusians * Bruno (bishop of Segni) (c. 1045–1123), Italian Roman Catholic bishop and saint * Bruno (archbishop of Trier) (died 1124), German Roman ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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