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Oral Polio Vaccine AIDS Hypothesis
The oral polio vaccine (OPV) AIDS hypothesis is a now-discredited hypothesis that the AIDS pandemic originated from live polio vaccines prepared in chimpanzee tissue cultures, accidentally contaminated with simian immunodeficiency virus and then administered to up to one million Africans between 1957 and 1960 in experimental mass vaccination campaigns. Data analyses in molecular biology and phylogenetic studies contradict the OPV AIDS hypothesis; consequently, scientific consensus regards the hypothesis as disproven. A 2004 ''Nature'' article has described the hypothesis as "refuted". Background: polio vaccines Two vaccines are used throughout the world to combat poliomyelitis. The first, a polio vaccine developed by Jonas Salk, is an ''inactivated poliovirus vaccine'' (IPV), consisting of a mixture of three wild, virulent strains of poliovirus, grown in a type of monkey kidney tissue culture (Vero cell line), and made noninfectious by formaldehyde treatment. The second v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AIDS
Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual may not notice any symptoms, or may experience a brief period of influenza-like illness. Typically, this is followed by a prolonged incubation period with no symptoms. If the infection progresses, it interferes more with the immune system, increasing the risk of developing common infections such as tuberculosis, as well as other opportunistic infections, and tumors which are rare in people who have normal immune function. These late symptoms of infection are referred to as acquired immunodeficiency syndrome (AIDS). This stage is often also associated with unintended weight loss. HIV is spread primarily by unprotected sex (including anal and vaginal sex), contaminated blood transfusions, hypodermic needles, and from mother to child duri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physiological
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical and physical functions in a living system. According to the classes of organisms, the field can be divided into medical physiology, animal physiology, plant physiology, cell physiology, and comparative physiology. Central to physiological functioning are biophysical and biochemical processes, homeostatic control mechanisms, and communication between cells. ''Physiological state'' is the condition of normal function. In contrast, ''pathological state'' refers to abnormal conditions, including human diseases. The Nobel Prize in Physiology or Medicine is awarded by the Royal Swedish Academy of Sciences for exceptional scientific achievements in physiology related to the field of medicine. Foundations Cells Although there are differe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Equatorial Africa
Equatorial Africa is an ambiguous term that sometimes is used to refer either to the equatorial region of Sub-Saharan Africa traversed by the Equator, more broadly to tropical Africa or in a biological and geo-environmental sense to the intra-tropical African rainforest region. See also * Central Africa * French Equatorial Africa * Sahara * Sahel * Sudan (region) * Tropics The tropics are the regions of Earth surrounding the Equator. They are defined in latitude by the Tropic of Cancer in the Northern Hemisphere at N and the Tropic of Capricorn in the Southern Hemisphere at S. The tropics are also referred to ... References External links * * {{cite web, title=Africa - Equatorial Africa Deposition Network (EADN) Project, url=http://documents.worldbank.org/curated/en/2006/01/7245100/africa-equatorial-africa-deposition-network-eadn-project#, publisher=The World Bank Group, access-date=12 August 2015, language=en, format=pdf Central Africa Geography of Africa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
French West Africa
French West Africa (french: Afrique-Occidentale française, ) was a federation of eight French colonial territories in West Africa: Mauritania, Senegal, French Sudan (now Mali), French Guinea (now Guinea), Ivory Coast, Upper Volta (now Burkina Faso), Dahomey (now Benin) and Niger. The federation existed from 1895 until 1958. Its capital was Saint-Louis, Senegal until 1902, and then Dakar until the federation's collapse in 1960. History Until after World War II, almost none of the Africans living in the colonies of France were citizens of France. Rather, they were "French subjects", lacking rights before the law, property ownership rights, rights to travel, dissent, or vote. The exception was the Four Communes of Senegal: those areas had been towns of the tiny Senegal Colony in 1848 when, at the abolition of slavery by the French Second Republic, all residents of France were granted equal political rights. Anyone able to prove they were born in these towns was legally Fre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
African Green Monkey
''Chlorocebus'' is a genus of medium-sized primates from the family of Old World monkeys. Six species are currently recognized, although some people classify them all as a single species with numerous subspecies. Either way, they make up the entirety of the genus ''Chlorocebus''. Confusingly, the terms "vervet monkey" and "green monkey" are sometimes used to refer to the whole genus ''Chlorocebus'', though they also refer more precisely to species '' Chlorocebus pygerythrus'' and ''Chlorocebus sabaeus'', respectively, neither of which is the type species for ''Chlorocebus''. This article uses the term ''Chlorocebus'' consistently for the genus and the common names only for the species. The native range of these monkeys is sub-Saharan Africa from Senegal and Ethiopia south to South Africa. However, in previous centuries, a number of them were taken as pets by early Caribbean settlers and slave traders, and were transported across the Atlantic Ocean to the Caribbean island ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tissue Culture
Tissue culture is the growth of tissues or cells in an artificial medium separate from the parent organism. This technique is also called micropropagation. This is typically facilitated via use of a liquid, semi-solid, or solid growth medium, such as broth or agar. Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. The term "tissue culture" was coined by American pathologist Montrose Thomas Burrows. Historical use In 1885 Wilhelm Roux removed a section of the medullary plate of an embryonic chicken and maintained it in a warm saline solution for several days, establishing the basic principle of tissue culture. In 1907 the zoologist Ross Granville Harrison demonstrated the growth of frog embryonic cells that would give rise to nerve cells in a medium of clotted lymph. In 1913, E. Steinhardt, C. Israeli, and R. A. Lambert grew vaccinia virus in fragments of guinea pig corneal tiss ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kinshasa
Kinshasa (; ; ln, Kinsásá), formerly Léopoldville ( nl, Leopoldstad), is the capital and largest city of the Democratic Republic of the Congo. Once a site of fishing and trading villages situated along the Congo River, Kinshasa is now one of the world's fastest growing megacities. The city of Kinshasa is also one of the DRC's 26 provinces. Because the administrative boundaries of the city-province cover a vast area, over 90 percent of the city-province's land is rural in nature, and the urban area occupies a small but expanding section on the western side. Kinshasa is Africa's third-largest metropolitan area after Cairo and Lagos. It is also the world's largest nominally Francophone urban area, with French being the language of government, education, media, public services and high-end commerce in the city, while Lingala is used as a ''lingua franca'' in the street. Kinshasa hosted the 14th Francophonie Summit in October 2012. Residents of Kinshasa are known as ''Kinoi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burundi
Burundi (, ), officially the Republic of Burundi ( rn, Repuburika y’Uburundi ; Swahili language, Swahili: ''Jamuhuri ya Burundi''; French language, French: ''République du Burundi'' ), is a landlocked country in the Great Rift Valley at the junction between the African Great Lakes region and East Africa. It is bordered by Rwanda to the north, Tanzania to the east and southeast, and the Democratic Republic of the Congo to the west; Lake Tanganyika lies along its southwestern border. The capital cities are Gitega and Bujumbura, the latter being the country's largest city. The Great Lakes Twa, Twa, Hutu and Tutsi peoples have lived in Burundi for at least 500 years. For more than 200 of those years, Burundi was an independent Kingdom of Burundi, kingdom, until the beginning of the 20th century, when it became a German colony. After the First World War and German Revolution of 1918–19, Germany's defeat, the League of Nations "mandated" the territory to Belgium. After the Secon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rwanda
Rwanda (; rw, u Rwanda ), officially the Republic of Rwanda, is a landlocked country in the Great Rift Valley of Central Africa, where the African Great Lakes region and Southeast Africa converge. Located a few degrees south of the Equator, Rwanda is bordered by Uganda, Tanzania, Burundi, and the Democratic Republic of the Congo. It is highly elevated, giving it the soubriquet "land of a thousand hills", with its geography dominated by mountains in the west and savanna to the southeast, with numerous lakes throughout the country. The climate is temperate to subtropical, with two rainy seasons and two dry seasons each year. Rwanda has a population of over 12.6 million living on of land, and is the most densely populated mainland African country; among countries larger than 10,000 km2, it is the fifth most densely populated country in the world. One million people live in the Capital city, capital and largest city Kigali. Hunter-gatherers settled the territory in the St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Democratic Republic Of The Congo
The Democratic Republic of the Congo (french: République démocratique du Congo (RDC), colloquially "La RDC" ), informally Congo-Kinshasa, DR Congo, the DRC, the DROC, or the Congo, and formerly and also colloquially Zaire, is a country in Central Africa. It is bordered to the northwest by the Republic of the Congo, to the north by the Central African Republic, to the northeast by South Sudan, to the east by Uganda, Rwanda, and Burundi, and by Tanzania (across Lake Tanganyika), to the south and southeast by Zambia, to the southwest by Angola, and to the west by the South Atlantic Ocean and the Cabinda exclave of Angola. By area, it is the second-largest country in Africa and the 11th-largest in the world. With a population of around 108 million, the Democratic Republic of the Congo is the most populous officially Francophone country in the world. The national capital and largest city is Kinshasa, which is also the nation's economic center. Centered on the Cong ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hilary Koprowski
Hilary Koprowski (5 December 191611 April 2013) was a Polish virologist and immunologist active in the United States who demonstrated the world's first effective live polio vaccine. He authored or co-authored over 875 scientific papers and co-edited several scientific journals. Koprowski received many academic honors and national decorations, including the Belgian Order of the Lion, the French Order of Merit and Legion of Honour, Finland's Order of the Lion, and the Order of Merit of the Republic of Poland. Koprowski was the target of accusations in the press related to the " oral polio vaccine AIDS hypothesis", which posited that the AIDS pandemic originated from live polio vaccines such as Koprowski's. This allegation has long been refuted by evidence showing that the HIV-1 virus was introduced to humans before his polio-vaccine trials were conducted in Africa. The case was settled out of court with a formal apology from ''Rolling Stone'' magazine. Life Hilary Koprowski ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Sabin
Albert Bruce Sabin ( ; August 26, 1906 – March 3, 1993) was a Polish-American medical researcher, best known for developing the oral polio vaccine, which has played a key role in nearly eradicating the disease. In 1969–72, he served as the president of the Weizmann Institute of Science in Israel. Biography Abram Saperstejn (later Albert Sabin) was born in Białystok, Russian Empire (before and since 1918 in Poland), to Polish-Jewish parents, Jacob Saperstejn and Tillie Krugman. In 1921, he emigrated with his family on the SS ''Lapland'' which sailed from Antwerp, Belgium, to the Port of New York. In 1930, he became a naturalized citizen of the United States and changed his name to Sabin, as well as assuming the middle name Bruce. He graduated from high school in Paterson, New Jersey. Sabin began university in a dentistry program, but was interested in virology and changed majors. He received a bachelor's degree in science in 1928 and a medical degree in 1931 from New Yo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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