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Methoxy Polyethylene Glycol-epoetin Beta
Methoxy polyethylene glycol-epoetin beta is the active ingredient of a drug marketed by Hoffmann-La Roche under the brand name Mircera. Mircera is a long-acting erythropoietin receptor activator (CERA) indicated for the treatment of patients with anaemia associated with chronic kidney disease. It is the first approved, chemically modified erythropoiesis-stimulating agent (ESA). Mircera is supplied as a solution in pre-filled syringes for intravenous or subcutaneous administration. Mircera was approved for use in Europe in July 2007 by the European Commission, in September 2007 by the Swissmedic, and in November 2007 by the U.S. Food and Drug Administration for use in the United States. Methoxy polyethylene glycol-epoetin beta is made from erythropoietin by chemically linking the N-terminal amino group or the ε-amino group of any lysine present in the protein with methoxy polyethylene glycol butanoic acid. The average molecular weight is approximately 60 kDa. The drug stimula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Injunction
An injunction is a legal and equitable remedy in the form of a special court order that compels a party to do or refrain from specific acts. ("The court of appeals ... has exclusive jurisdiction to enjoin, set aside, suspend (in whole or in part), or to determine the validity of...."); ("Limit on injunctive relief'); '' Jennings v. Rodriguez'', 583 U.S. ___, ___138 S.Ct. 830 851 (2018); '' Wheaton College v. Burwell''134 S.Ct. 2806 2810-11 (2014) ("Under our precedents, an injunction is appropriate only if (1) it is necessary or appropriate in aid of our jurisdiction, and (2) the legal rights at issue are indisputably clear.") (internal quotation marks and brackets omitted); '' Lux v. Rodrigues''561 U.S. 1306 1308 (2010); ''Correctional Services Corp. v. Malesko''534 U.S. 61 74 (2001) (stating that "injunctive relief has long been recognized as the proper means for preventing entities from acting unconstitutionally."); '' Nken v. Holder''556 U.S. 418(2009); see also ''Alli v. D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythropoiesis-stimulating Agents
Erythropoiesis-stimulating agents (ESA) are medications which stimulate the bone marrow to make red blood cells. They are used to treat anemia due to end stage kidney disease, chemotherapy, major surgery, or certain treatments in HIV/AIDS. In these situations they decrease the need for blood transfusions. The different agents are more or less equivalent. They are given by injection. Common side effects may include joint pain, rash, vomiting, and headache. Serious side effects may include heart attacks, stroke, increased cancer growth, or pure red cell aplasia. It is unclear if use is safe during pregnancy. They work similar to naturally occurring erythropoietin. They were first approved for medical use in the United States in 1989. It is on the World Health Organization's List of Essential Medicines. Commercially available agents include epoetin alfa and darbepoetin alfa, and biosimilars. Use among athletes is prohibited by the World Anti-Doping Agency. Medical uses ESAs ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antianemic Preparations
Anemia or anaemia (British English) is a blood disorder in which the blood has a reduced ability to carry oxygen due to a lower than normal number of red blood cells, or a reduction in the amount of hemoglobin. When anemia comes on slowly, the symptoms are often vague, such as Fatigue, tiredness, weakness, shortness of breath, headaches, and a Exercise intolerance, reduced ability to exercise. When anemia is acute, symptoms may include confusion, lightheadedness, feeling like one is going to pass out, Syncope (medicine), loss of consciousness, and polydipsia, increased thirst. Anemia must be significant before a person becomes noticeably Pallor, pale. Symptoms of anemia depend on how quickly hemoglobin decreases. Additional symptoms may occur depending on the underlying cause. Preoperative anemia can increase the risk of needing a blood transfusion following surgery. Anemia can be temporary or long term and can range from mild to severe. Anemia can be caused by blood loss, dec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PEGylation
PEGylation (or pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated. PEGylation affects the resulting derivatives or aggregates interactions, which typically slows down their coalescence and degradation as well as elimination in vivo. PEGylation is routinely achieved by the incubation of a reactive derivative of PEG with the target molecule. The covalent attachment of PEG to a drug or therapeutic protein can "mask" the agent from the host's immune system (reducing immunogenicity and antigenicity), and increase its hydrodynamic size (size in solution), which prolongs its circulatory time by reducing renal clearance. PEGylation can also provide water solubility to hydrophobic drugs and proteins. Having proven its pharmacological advantages and acceptability, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Union Cycliste Internationale
The ''Union Cycliste Internationale'' (UCI; ; en, International Cycling Union) is the world governing body for sports cycling and oversees international competitive cycling events. The UCI is based in Aigle, Switzerland. The UCI issues racing licenses to riders and enforces disciplinary rules, such as in matters of doping. The UCI also manages the classification of races and the points ranking system in various cycling disciplines including road and track cycling, mountain biking and BMX, for both men and women, amateur and professional. It also oversees the World Championships. After the 2022 Russian invasion of Ukraine, the UCI said that Russian and Belarusian teams are forbidden from competing in international events. It also stripped both Russia and Belarus of scheduled events. History UCI was founded in 1900 in Paris by the national cycling sports organisations of Belgium, the United States, France, Italy, and Switzerland. It replaced the International Cycling Associ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
French Anti-Doping Agency
The French Anti-Doping Agency (, AFLD) is an independent public authority formed in 2006 and charged with ensuring that participants in sports in France do not violate rules regarding doping. As a national anti-doping organization ( NADO), the AFLD cooperates with the World Anti-Doping Agency (WADA) and with other signatory organizations of the World Anti-Doping Code such as international sports federations. The agency has been particularly prominent in cases involving the Tour de France, such as that of Floyd Landis, who was stripped of his title in the 2006 race. A breakdown in the relationship between AFLD and the Union Cycliste Internationale in relation to testing procedures in the 2009 Tour de France lead to the severance of the role which gave AFLD their highest profile cases. AFLD Departments * Testing Department * Department of legal and institutional affairs * Intelligence and investigation department * Education and prevention Assignments Anti-Doping testi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
French Cycling Federation
The Fédération Française de Cyclisme (''FFC'') or French Cycling Federation is the national governing body of cycle racing in France. The FFC is a member of the UCI and the UEC. In February 2009, David Lappartient was elected for a four-year term as president. History The ''Union Vélocipédique Française'' (UVF) was the predecessor of the FFC. It was founded on 6 February 1881 in Paris at the ''Café Le Marengo'' by delegates of ten cycling clubs, who on the same day decided to create a national championship race of 10 km. The first president was Parisian Paul Devilliers, and from the start the UVF admitted professional riders. The UVF was reformed on 20 December 1940, becoming the FFC. Organisation The executive board is composed of a president, six vice-presidents, a general secretary, and a general treasurer. Executive board * President : David Lapartient * General secretary : Patrick Roy * General treasurer : Pierre Pouyet External links French Cycling ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tour De France
The Tour de France () is an annual men's multiple-stage bicycle race primarily held in France, while also occasionally passing through nearby countries. Like the other Grand Tours (the Giro d'Italia and the Vuelta a España), it consists of 21 stages, each a day long, over the course of 23 days, coinciding with the Bastille Day holiday. It is the oldest of the Grand Tours and generally considered the most prestigious. The race was first organized in 1903 to increase sales for the newspaper '' L'Auto'' and is currently run by the Amaury Sport Organisation. The race has been held annually since its first edition in 1903 except when it was stopped for the two World Wars. As the Tour gained prominence and popularity, the race was lengthened and its reach began to extend around the globe. Participation expanded from a primarily French field as more riders from all over the world began to participate in the race each year. The Tour is a UCI World Tour event, which means that th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Riccardo Riccò
Riccardo Riccò (born 1 September 1983) is an Italian professional road bicycle racer, who is suspended from all competition until 2024. He was previously ejected from the 2008 Tour de France for doping violations and suspended. Riccò returned to competition in late 2010, but in February 2011 he was fired by his team, , after he became seriously ill allegedly through a self-administered autologous blood transfusion. He then signed to UCI Continental team . On 19 April 2012 it was announced that he had been suspended for 12 years effectively ending his career. Career Born in Formigine, Riccò joined UCI ProTeam in 2006 after two successful seasons as an amateur rider, during which he won the Settimana Bergamasca. Prior to joining the team he tried to become a professional with in 2005 but was not allowed because several blood tests revealed his hematocrit levels exceeded those acceptable. Saunier Duval's sportif director, Mauro Gianetti, suggested he spend a week in the UCI ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World Anti-Doping Agency
The World Anti-Doping Agency (WADA; french: Agence mondiale antidopage, AMA) is a foundation initiated by the International Olympic Committee based in Canada to promote, coordinate, and monitor the fight against drugs in sports. The agency's key activities include scientific research, education, development of anti-doping capacities, and monitoring of the World Anti-Doping Code, whose provisions are enforced by the UNESCO International Convention Against Doping in Sport. The aims of the Council of Europe Anti-Doping Convention and the United States Anti-Doping Agency are also closely aligned with those of WADA. History The World Anti-Doping Agency is a foundation created through a collective initiative led by the International Olympic Committee (IOC). It was set up on 10 November 1999 in Lausanne, Switzerland, as a result of what was called the "Declaration of Lausanne", to promote, coordinate and monitor the fight against drugs in sports. Since 2002, the organization's head ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
France
France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pacific and Indian Oceans. Its Metropolitan France, metropolitan area extends from the Rhine to the Atlantic Ocean and from the Mediterranean Sea to the English Channel and the North Sea; overseas territories include French Guiana in South America, Saint Pierre and Miquelon in the North Atlantic, the French West Indies, and many islands in Oceania and the Indian Ocean. Due to its several coastal territories, France has the largest exclusive economic zone in the world. France borders Belgium, Luxembourg, Germany, Switzerland, Monaco, Italy, Andorra, and Spain in continental Europe, as well as the Kingdom of the Netherlands, Netherlands, Suriname, and Brazil in the Americas via its overseas territories in French Guiana and Saint Martin (island), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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