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Matrine
Matrine is an alkaloid found in plants from the genus ''Sophora''. It has a variety of pharmacological effects, including anti-cancer effects, as well as κ-opioid and μ-opioid receptor agonism. Matrine possesses strong antitumor activities ''in vitro'' and ''in vivo''. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities. Matrine is a component of the traditional Chinese medical herb ''Sophora flavescens'' Ait. Mu opioid agonism is associated with euphoria, while kappa opioid agonism is associated with dysphoria and psychotomimetic hallucinations (as seen in the kappa-agonist Salvinorin A). Both receptors are known to produce analgesia when activated. Matrine and the related compound oxymatrine have an antifeedant effect against formosan subterranean termite. Additionally, it acts as a nematicide against the pine wood nematode which causes pine wilt ''Bursaphelenchus xylophilus'', commonly kno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxymatrine
Oxymatrine (matrine oxide, matrine ''N''-oxide, matrine 1-oxide) is one of many Quinolizidine alkaloids, quinolizidine alkaloid compounds extracted from the root of ''Sophora flavescens'', a Chinese herb. It is very similar in structure to matrine, which has one less oxygen atom. Oxymatrine has a variety of effects ''in vitro'' and in animal models, including protection against apoptosis, tumor and fibrotic tissue development, and inflammation. Furthermore, oxymatrine has been shown to decrease cardiac ischemia (decreased blood perfusion), myocardial injury, Heart arrhythmia, arrhythmias (irregular heartbeats), and improve heart failure by increasing cardiac function. Role in cardiac fibrosis Recent research has shown that oxymatrine prevents cardiac fibrosis in rats.Shen, X, Yang, Y, Xiao, T, Peng, J, Liu, X. (2011) Protective effect of oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats involved in TGF-b1-Smads signal pathway. Journal of Asian Natural ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quinolizidine Alkaloids
Quinolizidine alkaloids are natural products that have a quinolizidine structure; this includes the lupine alkaloids. Occurrence Quinolizidine alkaloids can be found in the plant family of legumes, especially in papilionaceous plants. While the lupine alkaloids (following their name) can be found in lupines, tinctorin, for example, was isolated from the dyer's broom. Examples More than 200 quinolizidine alkaloids are known which can be classified into 6 structural types: * the lupinine type with 34 known structures, including lupinine and its derivatives * the camoensine type with 6 known structures, including camoensin * the spartein type with 66 structures, including sparteine, lupanine, angustifoline * the α-pyridone type with 25 structures, including anagyrine and cytisine * the matrine type with 31 structures, including matrine * and the ormosanin type with 19 structures, including ormosanine. (–)-Lupinine Structural Formula V2.svg, (–)-lupinine (6R,7S,9S,1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sophora Flavescens
''Sophora flavescens'', the shrubby sophora, is a species of plant in the genus ''Sophora'' of the family Fabaceae. This genus contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceania, and the Pacific islands. About fifteen of these species have a long history of use in traditional Chinese medicines. Growth and cultivation ''Sophora flavescens'' is an evergreen slow growing shrub growing to by . It is hardy to and to Hardiness zone, US zone 6. The plant prefers light (sandy), medium (loamy) and heavy (clay) soils and requires well-drained soil. The plant prefers acid, neutral and basic (alkaline) soils. It cannot grow in the shade. It requires moist soil. Like many other species in the family Fabaceae, this species can Nitrogen fixation, fix nitrogen. Chemistry Chemical compounds isolated from ''S. flavescens'' include: * Matrine and matrine oxide, quinolizidine alkaloids found in the roots * Kushenin, a pterocarpan and iso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloids Found In Fabaceae
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , |
Pine Wood Nematode
''Bursaphelenchus xylophilus'', commonly known as pine wood nematode or pine wilt nematode (PWN), is a species of nematode that infects trees in the ''Pinus'' genus of coniferous trees and causes the disease pine wilt.''Bursaphelenchus xylophilus''. Nemaplex. UC Davis. While native to North America, it spread in the early 20th century to and in the latter half of the century to other areas of , including , |
Heterocyclic Compounds With 4 Rings
A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of its ring(s). Heterocyclic chemistry is the branch of organic chemistry dealing with the synthesis, properties, and applications of these heterocycles. Examples of heterocyclic compounds include all of the nucleic acids, the majority of drugs, most biomass (cellulose and related materials), and many natural and synthetic dyes. More than half of known compounds are heterocycles. 59% of US FDA-approved drugs contain nitrogen heterocycles. Classification The study of heterocyclic chemistry focuses especially on unsaturated derivatives, and the preponderance of work and applications involves unstrained 5- and 6-membered rings. Included are pyridine, thiophene, pyrrole, and furan. Another large class of heterocycles refers to those fused to benzene rings. For example, the fused benzene derivatives of pyridine, thiophene, pyrrole, and furan are quinol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nitrogen Heterocycles
Nitrogen is the chemical element with the symbol N and atomic number 7. Nitrogen is a nonmetal and the lightest member of group 15 of the periodic table, often called the pnictogens. It is a common element in the universe, estimated at seventh in total abundance in the Milky Way and the Solar System. At standard temperature and pressure, two atoms of the element bond to form N2, a colorless and odorless diatomic gas. N2 forms about 78% of Earth's atmosphere, making it the most abundant uncombined element. Nitrogen occurs in all organisms, primarily in amino acids (and thus proteins), in the nucleic acids ( DNA and RNA) and in the energy transfer molecule adenosine triphosphate. The human body contains about 3% nitrogen by mass, the fourth most abundant element in the body after oxygen, carbon, and hydrogen. The nitrogen cycle describes the movement of the element from the air, into the biosphere and organic compounds, then back into the atmosphere. Many industrially importa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lactams
A lactam is a cyclic amide, formally derived from an amino alkanoic acid. The term is a portmanteau of the words ''lactone'' + ''amide''. Nomenclature Greek prefixes in alphabetical order indicate ring size: * α-Lactam (3-atom rings) * β-Lactam (4-atom rings) * γ-Lactam (5-atom rings) * δ-Lactam (6-atom rings) * ε-Lactam (7-atom rings) This ring-size nomenclature stems from the fact that a hydrolyzed α-Lactam leads to an α-amino acid and a β-Lactam to a β-amino acid, ''etc''. Synthesis General synthetic methods exist for the organic synthesis of lactams. Beckmann rearrangement Lactams form by the acid-catalyzed rearrangement of oximes in the Beckmann rearrangement. Schmidt reaction Lactams form from cyclic ketones and hydrazoic acid in the Schmidt reaction. Cyclization of amino acids Lactams can be formed from cyclisation of amino acids via the coupling between an amine and a carboxylic acid within the same molecule. Lactamization is most efficient in this wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pine Wilt
''Bursaphelenchus xylophilus'', commonly known as pine wood nematode or pine wilt nematode (PWN), is a species of nematode that infects trees in the ''Pinus'' genus of coniferous trees and causes the disease pine wilt.''Bursaphelenchus xylophilus''. Nemaplex. UC Davis. While native to North America, it spread in the early 20th century to and in the latter half of the century to other areas of , including , |
Formosan Subterranean Termite
The Formosan termite (''Coptotermes formosanus'') is a species of termite local to southern China and introduced to Taiwan (formerly known as Formosa, where it gets its name), Japan, South Africa, Sri Lanka, Hawaii, and the continental United States. The Formosan termite is often nicknamed the super-termite because of its destructive habits due to the large size of its colonies and its ability to consume wood at a rapid rate. Populations of these termites have become large enough to appear on New Orleans' weather radars. A mature Formosan colony can consume as much as 13 ounces of wood a day (about 400 g) and can severely damage a structure in as little as three months. Formosan termites infest a wide variety of structures (including boats and high-rise condominiums) and can damage trees. In the United States, along with another species, ''Coptotermes gestroi'', introduced from Southeast Asia, they are responsible for tremendous damage to property resulting in large treatment ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
