Macromerine
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Macromerine
Macromerine is a phenethylamine derivative. It was first identified from the cactus '' Coryphantha macromeris''. It can also be found in ''C. runyonii'', ''C. elephantidens'', and other related members of the family Cactaceae. The plants may have been used by Tarahumara shamans for their entheogen Entheogens are psychoactive substances that induce alterations in perception, mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwiseRätsch, Christian, ''The Encyclopedia of Psychoac ...ic effects. Chemistry Macromerine is a phenethylamine derivative with the molecular formula C12H19NO3. Effects At least one study found macromerine to be non-psychoactive, however as a phenethylamine derivative, it may be psychoactive. See also * Phenethylamine cactus * Mescaline References {{Phenethylamines Phenethylamine alkaloids Phenethylamines Phenol ethers Phenylethanolamines ...
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Phenethylamine
Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace amine-associated receptor 1 (TAAR1) and inhibiting vesicular monoamine transporter 2 (VMAT2) in monoamine neurons. To a lesser extent, it also acts as a neurotransmitter in the human central nervous system. In mammals, phenethylamine is produced from the amino acid L-phenylalanine by the enzyme aromatic L-amino acid decarboxylase via enzymatic decarboxylation. In addition to its presence in mammals, phenethylamine is found in many other organisms and foods, such as chocolate, especially after microbial fermentation. Phenethylamine is sold as a dietary supplement for purported mood and weight loss-related therapeutic benefits; however, in orally ingested phenethylamine, a significant amount is metabolized in the small intestine by monoami ...
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Coryphantha Macromeris
''Coryphantha macromeris'', the nipple beehive cactus, is a species of cactus in the United States and Mexico. In the Chihuhuan Desert, it is common and has a wide range. In the United States, it occurs naturally in Texas and New Mexico. It prefers to grown in the shade under other larger plants, growing in irregular clusters or mounds. In late summer, it blooms with purple or pink flowers and then bears green fruit. Biochemistry The phenethylamine macromerine Macromerine is a phenethylamine derivative. It was first identified from the cactus '' Coryphantha macromeris''. It can also be found in ''C. runyonii'', ''C. elephantidens'', and other related members of the family Cactaceae. The plants may hav ... is present in the cactus. References {{Taxonbar, from=Q1135881 macromeris Flora of the Southwestern United States Cacti of the United States Cacti of Mexico Flora of Mexico ...
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Cactaceae
A cactus (, or less commonly, cactus) is a member of the plant family Cactaceae, a family comprising about 127 genera with some 1750 known species of the order Caryophyllales. The word ''cactus'' derives, through Latin, from the Ancient Greek word (''káktos''), a name originally used by Theophrastus for a spiny plant whose identity is now not certain. Cacti occur in a wide range of shapes and sizes. Although some species live in quite humid environments, most cacti live in habitats subject to at least some drought. Many live in extremely dry environments, even being found in the Atacama Desert, one of the driest places on Earth. Because of this, cacti show many adaptations to conserve water. For example, almost all cacti are succulents, meaning they have thickened, fleshy parts adapted to store water. Unlike many other succulents, the stem is the only part of most cacti where this vital process takes place. Most species of cacti have lost true leaves, retaining only Thorns, s ...
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Shamans
Shamanism is a religious practice that involves a practitioner (shaman) interacting with what they believe to be a spirit world through altered states of consciousness, such as trance. The goal of this is usually to direct spirits or spiritual energies into the physical world for the purpose of healing, divination, or to aid human beings in some other way. Beliefs and practices categorized as "shamanic" have attracted the interest of scholars from a variety of disciplines, including anthropologists, archeologists, historians, religious studies scholars, philosophers and psychologists. Hundreds of books and academic papers on the subject have been produced, with a peer-reviewed academic journal being devoted to the study of shamanism. In the 20th century, non-Indigenous Westerners involved in countercultural movements, such as hippies and the New Age created modern magicoreligious practices influenced by their ideas of various Indigenous religions, creating what has been term ...
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Entheogen
Entheogens are psychoactive substances that induce alterations in perception, mood (psychology), mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwiseRätsch, Christian, ''The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications'' pub. Park Street Press 2005 in sacred contexts. Anthropological study has established that entheogens are used for religion, religious, Magic (supernatural), magical, shamanism, shamanic, or spirituality, spiritual purposes in many parts of the world. Entheogens have traditionally been used to supplement many diverse practices geared towards achieving Transcendence (religion), transcendence, including divination, meditation, yoga, sensory deprivation, healings, asceticism, prayer, trance, rituals, chanting, Imitation of sounds in shamanism, imitation of sounds, hymns like peyote songs, Drum circle, drumming, and ecstatic dance. The Psychedelic drug, psychedelic experience ...
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Phenethylamine Cactus
Many cacti are known to be psychoactive, containing phenethylamine alkaloids such as mescaline. However, the two main ritualistic (folkloric) genera are ''Echinopsis'', of which the most psychoactive species is the San Pedro cactus (''Echinopsis pachanoi'', syn. ''Trichocereus pachanoi''), and ''Lophophora'', with peyote (''Lophophora williamsii'') being the most psychoactive species. Several other species pertaining to other genera are also psychoactive, though not always used with a ritualistic intent. Species Globular cacti *''Lophophora williamsii'' (peyote) Other "peyotes" *''Ariocarpus fissuratus'' *''Coryphantha compacta'' (syn. ''C. palmeri'') *''Pelecyphora aselliformis'' *''Pelecyphora strobiliformis'' *''Lophophora diffusa'' *''Ariocarpus retusus'' *''Ariocarpus agavoides''; '' kotschoubeyanus''; and other species *''Astrophytum asterias''; '' capricorne''; '' myriostigma''; and other species *''Aztekium ritteri''; and other species *''Coryphantha elephantidens''; ...
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Mescaline
Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Biological sources It occurs naturally in several species of cacti. It is also found in small amounts in certain members of the bean family, Fabaceae, including ''Acacia berlandieri''. However those claims concerning ''Acacia'' species have been challenged and have been unsupported in any additional analysis. History and use Peyote has been used for at least 5,700 years by Indigenous peoples of the Americas in Mexico. Europeans noted use of peyote in Native American religious ceremonies upon early contact, notably by the Huichols in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in South America, from Peru to Ecuador. While religious and ceremonial peyote use was widespread in the Aztec empire and northern M ...
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Phenethylamine Alkaloids
Phenethylamine (PEA) is an organic compound, natural product, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmitter, monoamine neurotransmission by binding to trace amine-associated receptor 1 (TAAR1) and inhibiting vesicular monoamine transporter 2 (VMAT2) in monoamine neurons. To a lesser extent, it also acts as a neurotransmitter in the human central nervous system. In mammals, phenethylamine biosynthesis, is produced from the amino acid L-phenylalanine by the enzyme aromatic L-amino acid decarboxylase via enzymatic decarboxylation. In addition to its presence in mammals, phenethylamine is found in many other organisms and foods, such as chocolate, especially after microorganism, microbial fermentation (food), fermentation. Phenethylamine is sold as a dietary supplement for purported Mood (psychology), mood and weight loss-related therapeutic benefits; howeve ...
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Phenethylamines
Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative compounds of phenethylamine which can be formed by replacing, or substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents. The structural formula of any substituted phenethylamine contains a phenyl ring that is joined to an amino (NH) group via a two-carbon sidechain. Hence, any substituted phenethylamine can be classified according to the substitution of hydrogen (H) atoms on phenethylamine's phenyl ring, sidechain, or amino group with a specific group of atoms. Many substituted phenethylamines are psychoactive drugs which belong to a variety of different drug classes, including central nervous system stimulants (e.g., amphetamine), hallucinogens (e.g., dl- 2,5-dimethoxy-4-methylamphetamine DOM), entactogens (e.g., 3,4-methylenedioxyamphe ...
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Phenol Ethers
Phenol (also called carbolic acid) is an aromatic organic compound with the molecular formula . It is a white crystalline solid that is volatile. The molecule consists of a phenyl group () bonded to a hydroxy group (). Mildly acidic, it requires careful handling because it can cause chemical burns. Phenol was first extracted from coal tar, but today is produced on a large scale (about 7 billion kg/year) from petroleum-derived feedstocks. It is an important industrial commodity as a precursor to many materials and useful compounds. It is primarily used to synthesize plastics and related materials. Phenol and its chemical derivatives are essential for production of polycarbonates, epoxies, Bakelite, nylon, detergents, herbicides such as phenoxy herbicides, and numerous pharmaceutical drugs. Properties Phenol is an organic compound appreciably soluble in water, with about 84.2 g dissolving in 1000 mL (0.895 M). Homogeneous mixtures of phenol and water at phenol to ...
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