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Methylphenethylamine
Methylphenethylamine may refer to: * α-Methylphenethylamine (amphetamine) * β-Methylphenethylamine * ''N''-Methylphenethylamine (an endogenous trace amine in humans) * 2-Methylphenethylamine * 3-Methylphenethylamine * 4-Methylphenethylamine See also *Phenethylamine Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace amin ...
, with the organic chemistry name phenyl-ethyl-amine {{Chemistry index ...
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Amphetamine
Amphetamine (contracted from alpha- methylphenethylamine) is a strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. It is also commonly used as a recreational drug. Amphetamine was discovered in 1887 and exists as two enantiomers: levoamphetamine and dextroamphetamine. ''Amphetamine'' properly refers to a specific chemical, the racemic free base, which is equal parts of the two enantiomers in their pure amine forms. The term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an athletic performance enhancer and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant. It is a prescription drug in many countries, and unauthorized possession and distribution of amphetamine are often tightly controlled due to ...
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β-Methylphenethylamine
β-Methylphenethylamine (β-Me-PEA, BMPEA, or 1-amino-2-phenylpropane) is an organic compound of the phenethylamine class, and a positional isomer of the drug amphetamine, with which it shares some properties. In particular, both amphetamine and β-methylphenethylamine are human TAAR1 agonists. In appearance, it is a colorless or yellowish liquid. Relatively little information has been published about this substance. Hartung and Munch reported that it had good antihypotensive (pressor) activity in experimental animals, and that it was orally active. The MLD (minimum lethal dose) for the HCl salt was given as 500 mg/kg (rat, s.c.) and 50 mg/kg (rabbit, i.v.). A study by Graham and co-workers at the Upjohn Co., comparing many β-methylphenethylamines substituted on the benzene ring showed that β-methylphenethylamine itself had 1/700 x the pressor activity of epinephrine, corresponding to ~ 1/3 the potency of amphetamine. The β-methyl compound also had ~ 2 x the broncho ...
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4-Methylphenethylamine
4-Methylphenethylamine (4MPEA), also known as ''para''-methylphenethylamine, is an organic compound with the chemical formula of . 4MPEA is a human trace amine associated receptor 1 (TAAR1) agonist, a property which it shares with its monomethylated phenethylamine isomers, such as amphetamine (α-methylphenethylamine), , and (a trace amine). 4MPEA also appears to inhibit the human cytochrome P450 enzymes CYP1A2 Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. In humans, the CYP1A2 enzyme is encoded by the ''CYP1A2'' gene. Function ... and CYP2A6, based upon the published literature. References Phenethylamines TAAR1 agonists {{amine-stub ...
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2-Methylphenethylamine
2-Methylphenethylamine (2MPEA) is an organic compound with the chemical formula of . 2MPEA is a human trace amine associated receptor 1 (TAAR1) agonist, a property which it shares with its monomethylated phenethylamine isomers, such as amphetamine (α-methylphenethylamine), , and (a trace amine Trace amines are an endogenous group of trace amine-associated receptor 1 (TAAR1) agonists – and hence, monoaminergic neuromodulators – that are structurally and metabolically related to classical monoamine neurotransmitters. Compared to the ...). Very little data, even on toxicity, is available about its effects on humans other than that it activates the human TAAR1 receptor. References Phenethylamines TAAR1 agonists {{amine-stub ...
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3-Methylphenethylamine
3-Methylphenethylamine (3MPEA) is an organic compound with the chemical formula of . 3MPEA is a human trace amine associated receptor 1 (TAAR1) agonist, a property which it shares with its monomethylated phenethylamine isomers, such as amphetamine (α-methylphenethylamine), , and (a trace amine Trace amines are an endogenous group of trace amine-associated receptor 1 (TAAR1) agonists – and hence, monoaminergic neuromodulators – that are structurally and metabolically related to classical monoamine neurotransmitters. Compared to the ...). Very little data, even on toxicity, is available about its effects on humans other than that it is corrosive and activates the human TAAR1 receptor. References Phenethylamines TAAR1 agonists 3-Tolyl compounds {{amine-stub ...
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N-Methylphenethylamine
''N''-Methylphenethylamine (NMPEA) is a naturally occurring trace amine neuromodulator in humans that is derived from the trace amine, phenethylamine (PEA). It has been detected in human urine (<1 Î¼g over 24 hours) and is produced by with as a substrate. PEA and NMPEA are both that are found in a number of different plant species as well. Some ''