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Mansonelliasis
Mansonelliasis is the condition of infection by the nematode ''Mansonella''. The disease exists in Africa and tropical Americas, spread by biting midges or blackflies. It is usually asymptomatic. Symptoms and signs Infections by ''Mansonella perstans'', while often asymptomatic, can be associated with angioedema, pruritus, fever, headaches, arthralgias, and neurologic manifestations. ''Mansonella streptocerca'' can manifest on the skin via pruritus, papular eruptions and pigmentation changes. '' Mansonella ozzardi'' can cause symptoms that include arthralgias, headaches, fever, pulmonary symptoms, adenopathy, hepatomegaly, and pruritus. Eosinophilia is often prominent but do not occur in all cases of Mansonelliasis. ''M. perstans'' can also present with Calabar-like swellings, hives, and a condition known as Kampala, or Ugandan eye worm. This occurs when adult M. perstans invades the conjunctiva or periorbital connective tissues in the eye. ''M. perstans'' can also present with h ...
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Mansonella Perstans
''Mansonella perstans'' is a filarial (arthropod-borne) nematode (roundworm), transmitted by tiny blood-sucking flies called midges. ''Mansonella perstans'' is one of two filarial nematodes that causes serous cavity filariasis in humans. The other filarial nematode is '' Mansonella ozzardi''. ''M. perstans'' is widespread in many parts of sub-Saharan Africa, parts of Central and South America, and the Caribbean. Compared to infections with other filarial parasites such as ''Wuchereria bancrofti'', ''Brugia malayi'', and ''Loa loa'', ''Mansonella'' infections are relatively mild. However, the pathogenicity of ''M. perstans'' infection has been recently reconsidered in various studies. These studies have demonstrated that ''M. perstans'' has the ability to induce a variety of clinical features, including angioedema Calabar-like swellings, pruritus, fever, headache, eosinophilia, and abdominal pain. The overall disability among populations in regions where filariae are endemi ...
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Mansonella
''Mansonella'' is a genus of parasitic nematodes. It includes three species that are responsible for the disease mansonelliasis: ''Mansonella ozzardi'', ''M. perstans'', and ''M. streptocerca''. Species There are nine species: * '' Mansonella barbascalensis'' * '' Mansonella llewellyni'' Price, 1962 * '' Mansonella longicapitata'' Eberhard, Campo-Aasen & Orihel, 1984 * '' Mansonella ozzardi'' Manson, 1897 – parasite of humans in Central and South America * ''Mansonella perstans'' Manson, 1891 – parasite of humans and primates in Africa and South America * '' Mansonella rodhaini'' * '' Mansonella rotundicapitata'' Eberhard, Campo-Aasen & Orihel, 1984 * '' Mansonella semiclarum'' Fain, 1974 * ''Mansonella streptocerca ''Mansonella streptocerca'', (formerly ''Diptalonema streptocerca''), is a filarial (arthropod-borne) nematode (roundworm) causing the disease streptocerciasis. It is a common parasite in the skin of humans in the rain forests of Africa, where ...'' – pa ...
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Mansonella Streptocerca
''Mansonella streptocerca'', (formerly ''Diptalonema streptocerca''), is a filarial (arthropod-borne) nematode (roundworm) causing the disease streptocerciasis. It is a common parasite in the skin of humans in the rain forests of Africa, where it is thought to be a parasite of chimpanzees, as well. ''Mansonella streptocerca'' is one of three filarial nematodes that cause subcutaneous filariasis in humans. The other two filarial nematodes are ''Loa loa'' (the African eye worm), and ''Onchocerca volvulus'' (river blindness). The worm is distributed across West and Central Africa. Life cycle The contraction of an ''M. streptocerca'' infection can be better understood through an understanding of its life cycle. The life cycle involves two stages: one involving a midge (genus ''Culicoides'') and another involving a human host. First, a midge ingests a blood meal from a human host. This allows third-stage filarial larvae to enter the bite wound. Once inside the dermis, the larva ...
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Angioedema
Angioedema is an area of swelling ( edema) of the lower layer of skin and tissue just under the skin or mucous membranes. The swelling may occur in the face, tongue, larynx, abdomen, or arms and legs. Often it is associated with hives, which are swelling within the upper skin. Onset is typically over minutes to hours. The underlying mechanism typically involves histamine or bradykinin. The version related to histamine is due to an allergic reaction to agents such as insect bites, foods, or medications. The version related to bradykinin may occur due to an inherited problem known as C1 esterase inhibitor deficiency, medications known as angiotensin-converting enzyme inhibitors, or a lymphoproliferative disorder. Treatment to protect the airway may include intubation or cricothyroidotomy. Histamine-related angioedema can be treated with antihistamines, corticosteroids, and epinephrine. In those with bradykinin-related disease a C1 esterase inhibitor, ecallantide, or icati ...
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Pruritus
Itch (also known as pruritus) is a sensation that causes the desire or reflex to scratch. Itch has resisted many attempts to be classified as any one type of sensory experience. Itch has many similarities to pain, and while both are unpleasant sensory experiences, their behavioral response patterns are different. Pain creates a withdrawal reflex, whereas itch leads to a scratch reflex. Unmyelinated nerve fibers for itch and pain both originate in the skin; however, information for them is conveyed centrally in two distinct systems that both use the same nerve bundle and spinothalamic tract. Classification Most commonly, an itch is felt in one place. If it is felt all over the body, then it is called ''generalized itch'' or ''generalized pruritus''. If the sensation of itching persists for six weeks or longer, then it is called ''chronic itch'' or ''chronic pruritus''. ''Chronic idiopathic pruritus'' or ''essential pruritus'' is a rare form of itch that persists for longer t ...
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Arthralgias
Arthralgia (from Greek ''arthro-'', joint + ''-algos'', pain) literally means ''joint pain''. Specifically, arthralgia is a symptom of injury, infection, illness (in particular arthritis), or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. Causes The causes of ''arthralgia'' are varied and range, from a joints perspective, from degenerative and destructive processes such as osteoarthritis and sports injuries to inflammation of tissues surrounding the joints, such as bursitis. These might be triggered by other things, such as infections or vaccinations. Diagnosis Diagnosis involves interviewing the patient and performing physical exams. When attempting to establish the cause of the arthralgia, the emphasis is on the interview. The patient is asked questions intended to narrow the number of potential causes. Given t ...
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Mansonella Ozzardi
''Mansonella ozzardi'' is a filarial (arthropod-borne) nematode (roundworm). This filarial nematode is one of two that causes serous cavity filariasis in humans. The other filarial nematode that causes it in humans is ''Mansonella perstans''. ''M. ozzardi'' is an endoparasite that inhabits the serous cavity of the abdomen in the human host. It lives within the mesenteries, peritoneum, and in the subcutaneous tissue. Morphology Like other nematodes, ''M. ozzardi'' is a cylindrical and bilaterally symmetrical worm, with a pseudocoel, or a false body cavity. The exterior of the parasite, the cuticle, is a protective layer that can withstand the harsh environment in the digestive tracts of the human hosts. ''M. ozzardi'' and other nematodes have longitudinal muscles that run along the body wall. They also have dorsal, ventral, and longitudinal nerve cords connected to these longitudinal muscles. In the adult stages of ''M. ozzardi'', the females are larger than the males. ''M. o ...
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M Perstans LifeCycle
M, or m, is the thirteenth Letter (alphabet), letter in the Latin alphabet, used in the English alphabet, modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is English alphabet#Letter names, ''em'' (pronounced ), plural ''ems''. History The letter M is derived from the Phoenician alphabet, Phoenician Mem, via the Greek alphabet, Greek Mu (letter), Mu (Μ, μ). Semitic alphabets, Semitic Mem is most likely derived from a "Proto-Sinaitic script, Proto-Sinaitic" (Bronze Age) adoption of the N-water ripple (n hieroglyph), "water" ideogram in Egyptian hieroglyphs, Egyptian writing. The Egyptian sign had the acrophonic value , from the Egyptian word for "water", ''nt''; the adoption as the Semitic letter for was presumably also on acrophonic grounds, from the Semitic languages, Semitic word for "water", '':wikt:Reconstruction:Proto-Semitic/maʾ-, *mā(y)-''. Use in writing systems The letter represents the ...
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Congo Basin
The Congo Basin (french: Bassin du Congo) is the sedimentary basin of the Congo River. The Congo Basin is located in Central Africa, in a region known as west equatorial Africa. The Congo Basin region is sometimes known simply as the Congo. It contains some of the largest tropical rainforests in the world and is an important source of water used in agriculture and energy generation. The rainforest in the Congo Basin is the largest rainforest in Africa and second only to the Amazon rainforest in size, with 300 million hectares compared to the 800 million hectares in the Amazon. Because of its size and diversity, many experts have characterized the basin's forest as important for mitigating climate change because of its role as a carbon sink. However, deforestation and degradation of the ecology by the impacts of climate change may increase stress on the forest ecosystem, in turn making the hydrology of the basin more variable. A 2012 study found that the variability in precipita ...
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Filariasis
Filariasis is a parasitic disease caused by an infection with roundworms of the Filarioidea type. These are spread by blood-feeding insects such as black flies and mosquitoes. They belong to the group of diseases called helminthiases. These parasites exist in the wild in subtropical parts of southern Asia, Africa, the South Pacific, and parts of South America. One does not acquire them in temperate areas like Europe or the United States. Eight known filarial worms have humans as a definitive host. These are divided into three groups according to the part of the body they affect: * Lymphatic filariasis is caused by the worms ''Wuchereria bancrofti'', ''Brugia malayi'', and ''Brugia timori''. These worms occupy the lymphatic system, including the lymph nodes; in chronic cases, these worms lead to the syndrome of ''elephantiasis''. * Subcutaneous filariasis is caused by ''Loa loa'' (the eye worm), ''Mansonella streptocerca'', and ''Onchocerca volvulus''. These worms occupy the la ...
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