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Lung Transplantation
Lung transplantation, or pulmonary transplantation, is a surgical procedure in which one or both lungs are replaced by lungs from a donor. Donor lungs can be retrieved from a living or deceased donor. A living donor can only donate one lung lobe. With some lung diseases, a recipient may only need to receive a single lung. With other lung diseases such as cystic fibrosis, it is imperative that a recipient receive two lungs. While lung transplants carry certain associated risks, they can also extend life expectancy and enhance the quality of life for those with end stage pulmonary disease. Qualifying conditions Lung transplantation is the therapeutic measure of last resort for patients with end-stage lung disease who have exhausted all other available treatments without improvement. A variety of conditions may make such surgery necessary. As of 2005, the most common reasons for lung transplantation in the United States were: * 27% chronic obstructive pulmonary disease (COPD), incl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lung
The lungs are the primary organs of the respiratory system in humans and most other animals, including some snails and a small number of fish. In mammals and most other vertebrates, two lungs are located near the backbone on either side of the heart. Their function in the respiratory system is to extract oxygen from the air and transfer it into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere, in a process of gas exchange. Respiration is driven by different muscular systems in different species. Mammals, reptiles and birds use their different muscles to support and foster breathing. In earlier tetrapods, air was driven into the lungs by the pharyngeal muscles via buccal pumping, a mechanism still seen in amphibians. In humans, the main muscle of respiration that drives breathing is the diaphragm. The lungs also provide airflow that makes vocal sounds including human speech possible. Humans have two lungs, one on the left an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alcohol (drug)
Alcohol, sometimes referred to by the chemical name ''ethanol'', is a depressant drug that is the active ingredient in drinks such as beer, wine, and distilled spirits (hard liquor). It is one of the oldest and most commonly consumed recreational drugs, causing the characteristic effects of alcohol intoxication ("drunkenness"). Among other effects, alcohol produces happiness and euphoria, decreased anxiety, increased sociability, sedation, impairment of cognitive, memory, motor, and sensory function, and generalized depression of central nervous system (CNS) function. Ethanol is only one of several types of alcohol, but it is the only type of alcohol that is found in alcoholic beverages or commonly used for recreational purposes; other alcohols such as methanol and isopropyl alcohol are significantly more toxic. A mild, brief exposure to isopropanol, being only moderately more toxic than ethanol, is unlikely to cause any serious harm. Methanol, being profoundly more t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ciclosporin
Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is a natural product. It is taken orally or intravenously for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent rejection. It is also used as eye drops for keratoconjunctivitis sicca (dry eyes). Common side effects include high blood pressure, headache, kidney problems, increased hair growth, and vomiting. Other severe side effects include an increased risk of infection, liver problems, and an increased risk of lymphoma. Blood levels of the medication should be checked to decrease the risk of side effects. Use during pregnancy may result in preterm birth; however, ciclosporin does not appear to cause birth defects. Ciclosporin is believed to work by decreasing the function of lymphocytes. It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunosuppressive Drug
Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications, are drugs that inhibit or prevent activity of the immune system. Classification Immunosuppressive drugs can be classified into five groups: * glucocorticoids * cytostatics * antibodies * drugs acting on immunophilins * other drugs Glucocorticoids In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders. They are also administered as posttransplantory immunosuppressants to prevent the acute transplant rejection and graft-versus-host disease. Nevertheless, they do not prevent an infection and also inhibit later reparative processes. Immunosuppressive mechanism Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines Interleukin 1 (IL-1), IL-2, IL-3, IL-4, IL-5, IL-6 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heart-lung Machine
Cardiopulmonary bypass (CPB) is a technique in which a machine temporarily takes over the function of the heart and lungs during surgery, maintaining the circulation of blood and oxygen to the body. The CPB pump itself is often referred to as a heart–lung machine or "the pump". Cardiopulmonary bypass pumps are operated by perfusionists. CPB is a form of extracorporeal circulation. Extracorporeal membrane oxygenation is generally used for longer-term treatment. CPB mechanically circulates and oxygenates blood for the body while bypassing the heart and lungs. It uses a heart–lung machine to maintain perfusion to other body organs and tissues while the surgeon works in a bloodless surgical field. The surgeon places a cannula in the right atrium, vena cava, or femoral vein to withdraw blood from the body. Venous blood is removed from the body by the cannula and then filtered, cooled or warmed, and oxygenated before it is returned to the body by a mechanical pump. The cannula used ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transplant Rejection
Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant. Types of transplant rejection Transplant rejection can be classified into three types: hyperacute, acute, and chronic. These types are differentiated by how quickly the recipient's immune system is activated and the specific aspect or aspects of immunity involved. Hyperacute rejection Hyperacute rejection is a form of rejection that manifests itself in the minutes to hours following transplantation. It is caused by the presence of pre-existing antibodies in the recipient that recognize antigens in the donor organ. These antigens are located on the endothelial lining of blood vessels within the transplanted organ and, once antibodies bind, will lead to the rapid activation of the co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
June 1963
The following events occurred in June 1963: June 1, 1963 (Saturday) * Willie Pastrano, a 6 to 1 underdog challenger, won the world light heavyweight boxing championship, defeating titleholder Harold Johnson. Although most sportswriters thought that Johnson had won the 15 round bout in Las Vegas, Pastrano was declared the winner by the judges in a 2 to 1 decision. "I'm not saying that the underworld dictated the decision," Johnson's manager told reporters afterward, "but the betting was 5-1 and 6-1 for my boy? What do you think?" *In Vietnam, President Ngô Đình Diệm's office announced the dismissal of the three major officials involved in the Huế incident — the province chief and his deputy, and the government delegate for the Central Region of Vietnam — for failing to maintain order. *Jomo Kenyatta was sworn in as the first Prime Minister of Kenya. *Died: Alfred V. Kidder, 77, American archaeologist June 2, 1963 (Sunday) *Fred Lorenzen won the World 600 NASCA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Mississippi
The University of Mississippi ( byname Ole Miss) is a public research university that is located adjacent to Oxford, Mississippi, and has a medical center in Jackson. It is Mississippi's oldest public university and its largest by enrollment. The Mississippi Legislature chartered the university on February 24, 1844, and four years later it admitted its first 80 students. During the Civil War, the university operated as a Confederate hospital and narrowly avoided destruction by Ulysses S. Grant's forces. In 1962, during the civil rights movement, a race riot occurred on campus when segregationists tried to prevent the enrollment of African American student James Meredith. The university has since taken measures to improve its image. The university is closely associated with writer William Faulkner, and owns and manages his former Oxford home Rowan Oak, which with other on-campus sites Barnard Observatory and Lyceum–The Circle Historic District, is listed on the Nationa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Hardy (surgeon)
James D. Hardy (May 14, 1918 – February 19, 2003) was a United States surgeon who performed the world's first lung transplant with patient John Russell living for 18 days. The transplant was performed at the University of Mississippi Medical Center in Jackson, Mississippi on June 11, 1963. Hardy also performed the world's first modern heart transplant attempt when he transplanted the heart of a chimpanzee into comatose and dying Boyd Rush's chest during the early morning of January 24, 1964. This heart beat for approximately one hour, and then Rush died without ever regaining consciousness. The consent form did not include the possibility that a chimpanzee heart may be used, although Hardy stated that he had included this in discussions with Rush's stepsister. Before the transplant attempt, Hardy asked the four doctors who would be assisting him to please vote about whether to proceed. One said yes, one abstained, and the last two nodded yes. This operation was also perfo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vladimir Demikhov
Vladimir Petrovich Demikhov (russian: Владимир Петрович Демихов; July 31, 1916 – November 22, 1998) was a Soviet scientist and organ transplantation pioneer, who performed several transplants in the 1940s and 1950s, including the transplantation of a heart into an animal and a heart–lung replacement in an animal. He is also well known for his dog head transplants, which he conducted during the 1950s, resulting in two-headed dogs. This ultimately led to the head transplants in monkeys by Dr. Robert White, who was inspired by Demikhov's work. Early life Vladimir P. Demikhov was born on July 31, 1916, into a family of Russian peasants living on a small farmstead in the northern part of Russia's Volgograd region. His father, Demikhov Peter Yakovlevich, was killed during the Russian Civil War when Demikhov was about three years old, so he and his brother and sister were raised by their mother, Domnika Alexandrovna, who managed to provide th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transplant Rejection
Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant. Types of transplant rejection Transplant rejection can be classified into three types: hyperacute, acute, and chronic. These types are differentiated by how quickly the recipient's immune system is activated and the specific aspect or aspects of immunity involved. Hyperacute rejection Hyperacute rejection is a form of rejection that manifests itself in the minutes to hours following transplantation. It is caused by the presence of pre-existing antibodies in the recipient that recognize antigens in the donor organ. These antigens are located on the endothelial lining of blood vessels within the transplanted organ and, once antibodies bind, will lead to the rapid activation of the co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
