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The first recorded outbreak of syphilis in Europe occurred in 1494/1495 in Naples, Italy, during a French invasion. Because it was spread by returning French troops, the disease was known as "French disease", and it was not until 1530 that the term "syphilis" was first applied by the Italian physician and poet Girolamo Fracastoro. The causative organism, ''Treponema pallidum'', was first identified by Fritz Schaudinn and Erich Hoffmann in 1905. The first effective treatment, Salvarsan, was developed in 1910 by Sahachirō Hata in the laboratory of Paul Ehrlich. It was followed by the introduction of penicillin in 1943. Many well-known figures, including Scott Joplin, Franz Schubert, Friedrich Nietzsche, Al Capone, and Édouard Manet are believed to have contracted the disease. Origin The history of syphilis has been well studied, but the exact origin of the disease remains unknown. There are two primary hypotheses: one proposes that syphilis was carried to Europe from the America ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Al Capone
Alphonse Gabriel Capone (; January 17, 1899 – January 25, 1947), sometimes known by the nickname "Scarface", was an American gangster and businessman who attained notoriety during the Prohibition era as the co-founder and boss of the Chicago Outfit. His seven-year reign as a crime boss ended when he went to prison at the age of 33. Capone was born in New York City in 1899 to Italian immigrants. He joined the Five Points Gang as a teenager and became a bouncer in organized crime premises such as brothels. In his early twenties, he moved to Chicago and became a bodyguard and trusted factotum for Johnny Torrio, head of a criminal syndicate that illegally supplied alcohol—the forerunner of the Outfit—and was politically protected through the Unione Siciliana. A conflict with the North Side Gang was instrumental in Capone's rise and fall. Torrio went into retirement after North Side gunmen almost killed him, handing control to Capone. Capone expanded the bootlegging b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elephantiasis
Elephantiasis is the enlargement and hardening of limbs or body parts due to tissue swelling. It is characterised by edema, hypertrophy, and fibrosis of skin and subcutaneous tissues, due to obstruction of lymphatic vessels. It may affect the genitalia. The term elephantiasis is often used in reference to (symptoms caused by) parasitic worm infections, but may refer to a variety of diseases where parts of a person's body swell to massive proportions. __TOC__ Cause Some conditions that present with elephantiasis include: * Elephantiasis nostras, due to longstanding chronic lymphangitis * Elephantiasis tropica (known as lymphatic filariasis), caused by a number of parasitic worms, particularly ''Wuchereria bancrofti''. More than 120 million people, mostly in Africa and Southeast Asia, are affected. * Nonfilarial elephantiasis (or podoconiosis), an immune disease affecting the lymph vessels * Leishmaniasis * Elephantiasis, Grade 3 lymphedema which may occur in people with breast cance ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leprosy
Leprosy, also known as Hansen's disease (HD), is a long-term infection by the bacteria ''Mycobacterium leprae'' or ''Mycobacterium lepromatosis''. Infection can lead to damage of the nerves, respiratory tract, skin, and eyes. This nerve damage may result in a lack of ability to feel pain, which can lead to the loss of parts of a person's extremities from repeated injuries or infection through unnoticed wounds. An infected person may also experience muscle weakness and poor eyesight. Leprosy symptoms may begin within one year, but, for some people, symptoms may take 20 years or more to occur. Leprosy is spread between people, although extensive contact is necessary. Leprosy has a low pathogenicity, and 95% of people who contract ''M. leprae'' do not develop the disease. Spread is thought to occur through a cough or contact with fluid from the nose of a person infected by leprosy. Genetic factors and immune function play a role in how easily a person catches the disease. Lepro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endemic (epidemiology)
In epidemiology, an infection is said to be endemic in a specific population or populated place when that infection is constantly maintained at a baseline level without extra infections being brought into the group as a result of travel or similar means. An endemic disease always has a steady, predictable number of people getting sick, but that number can be high (''hyperendemic'') or low (''hypoendemic''), and the disease can be severe or mild. Also, a disease that is usually endemic can become epidemic. For example, chickenpox is endemic (steady state) in the United Kingdom, but malaria is not. Every year, there are a few cases of malaria reported in the UK, but these do not lead to sustained transmission in the population due to the lack of a suitable vector (mosquitoes of the genus ''Anopheles''). Consequently, the number of people infected by malaria is too variable to be called endemic. However, the number of people who get chickenpox in the UK varies little from year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pinta (disease)
Pinta (also known as azul, carate, empeines, lota, mal del pinto, and tina) is a human skin disease caused by infection with the spirochete ''Treponema carateum'', which is morphologically and serologically indistinguishable from the bacterium that causes syphilis. The disease is endemic to Mexico, Central America, and South America. Signs and symptoms Pinta, the least severe of treponemal infections being limited to the skin, is thought to be transmitted by skin-to-skin contact (similar to bejel and yaws), and after an incubation period of two to three weeks, produces a raised papule, which enlarges and becomes hyperkeratotic (scaly/flaky). Lesions are usually present in the exposed surface of arms and legs. Local lymph nodes might be enlarged. Three to nine months later, further thickened and flat lesions (pintids) appear all over the body. These generally resolve, but a proportion of people with pinta will go on to develop late-stage disease, characterised by widespread pig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yaws
Yaws is a tropical infection of the skin, bones, and joints caused by the spirochete bacterium ''Treponema pallidum pertenue''. The disease begins with a round, hard swelling of the skin, in diameter. The center may break open and form an ulcer. This initial skin lesion typically heals after 3–6 months. After weeks to years, joints and bones may become painful, fatigue may develop, and new skin lesions may appear. The skin of the palms of the hands and the soles of the feet may become thick and break open. The bones (especially those of the nose) may become misshapen. After 5 years or more, large areas of skin may die, leaving scars. Yaws is spread by direct contact with the fluid from a lesion of an infected person. The contact is usually of a nonsexual nature. The disease is most common among children, who spread it by playing together. Other related treponemal diseases are bejel (''T. pallidum endemicum''), pinta (''T. carateum''), and syphilis (''T. p. pallidum''). Ya ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nonvenereal Endemic Syphilis
Bejel, or endemic syphilis, is a chronic skin and tissue disease caused by infection by the ''endemicum'' subspecies of the spirochete ''Treponema pallidum''. Bejel is one of the "endemic treponematoses" (endemic infections caused by spiral-shaped bacteria called treponemes), a group that also includes yaws and pinta. Typically, endemic trepanematoses begin with localized lesions on the skin or mucous membranes. Pinta is limited to affecting the skin, whereas bejel and yaws are considered to be invasive because they can also cause disease in bone and other internal tissues. Signs and symptoms Bejel usually begins in childhood as a small patch on the mucosa, often on the interior of the mouth, followed by the appearance of raised, eroding lesions on the limbs and trunk. Periostitis (inflammation) of the leg bones is commonly seen, and gummas of the nose and soft palate develop in later stages. Causes Although the organism that causes bejel, ''Treponema pallidum endemicum'', is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Treponematosis
Treponematosis is a term used to individually describe any of the diseases caused by four members of the bacterial genus ''Treponema''. The four diseases are collectively referred to as treponematoses: * Syphilis (''Treponema pallidum pallidum'') * Yaws (''Treponema pallidum pertenue'') * Bejel (''Treponema pallidum endemicum'') * Pinta (disease), Pinta (''Treponema carateum'') Traditional laboratory tests cannot distinguish the treponematoses. However, sequence differences among the ''T. pallidum'' subspecies have been identified. Molecular approaches involving Polymerase chain reaction, PCR to identify these sequences are being developed. References External links Spirochaetes Bacterium-related cutaneous conditions {{infectious-disease-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sexually Transmitted Disease
Sexually transmitted infections (STIs), also referred to as sexually transmitted diseases (STDs) and the older term venereal diseases, are infections that are spread by sexual activity, especially vaginal intercourse, anal sex, and oral sex. STIs often do not initially cause symptoms, which results in a risk of passing the infection on to others. Symptoms and signs of STIs may include vaginal discharge, penile discharge, ulcers on or around the genitals, and pelvic pain. Some STIs can cause infertility. Bacterial STIs include chlamydia, gonorrhea, and syphilis. Viral STIs include genital herpes, HIV/AIDS, and genital warts. Parasitic STIs include trichomoniasis. STI diagnostic tests are usually easily available in the developed world, but they are often unavailable in the developing world. Some vaccinations may also decrease the risk of certain infections including hepatitis B and some types of HPV. Safe sex practices, such as use of condoms, having a smaller n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Printing Press
A printing press is a mechanical device for applying pressure to an inked surface resting upon a printing, print medium (such as paper or cloth), thereby transferring the ink. It marked a dramatic improvement on earlier printing methods in which the cloth, paper or other medium was brushed or rubbed repeatedly to achieve the transfer of ink, and accelerated the process. Typically used for texts, the invention and global spread of the printing press was one of the most influential events in the second millennium. In Germany, around 1440, goldsmith Johannes Gutenberg invented the movable-type printing press, which started the Printing Revolution. Modelled on the design of existing screw presses, a single Renaissance movable-type printing press could produce up to 3,600 pages per workday, compared to forty by History of typography in East Asia, hand-printing and a few by scribe, hand-copying. Gutenberg's newly devised matrix (printing), hand mould made possible the precise and ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Columbian Exchange
The Columbian exchange, also known as the Columbian interchange, was the widespread transfer of plants, animals, precious metals, commodities, culture, human populations, technology, diseases, and ideas between the New World (the Americas) in the Western Hemisphere, and the Old World ( Afro-Eurasia) in the Eastern Hemisphere, in the late 15th and following centuries. It is named after the Italian explorer Christopher Columbus and is related to the European colonization and global trade following his 1492 voyage. Some of the exchanges were purposeful; some were accidental or unintended. Communicable diseases of Old World origin resulted in an 80 to 95 percent reduction in the number of Indigenous peoples of the Americas from the 15th century onwards, most severely in the Caribbean. The cultures of both hemispheres were significantly impacted by the migration of people (both free and enslaved) from the Old World to the New. European colonists and African slaves replaced Indig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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