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Leishmaniasis Vaccine
A Leishmaniasis vaccine is a vaccine which would prevent leishmaniasis. As of 2017, no vaccine for humans was available. Currently some effective leishmaniasis vaccines for dogs exist. The parasite which causes leishmaniasis is '' Leishmania'', which is a Trypanosomatida. The disease spreads from sandflies. Animals such as dogs can be a vector for having the parasite, spreading it to sandflies, and from sandflies to humans. A vaccination strategy to control or eliminate Leishmaniasis might include developing a vaccine for humans and other vaccines for animals. Scientists wish for a vaccine and there is vaccine research. There is also consideration that public health practices can control or eliminate leishmaniasis without a vaccine. Leishmanization People who recover from leishmaniasis gain immunity from reinfection. "Leishmanization" is the practice of inoculation with live ''Leishmania'' to induce mild cutaneous leishmaniasis (CL) to prevent future dangerous infection. Some B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leishmania Culture In Hood 2
''Leishmania'' is a parasitic protozoan, a single-celled organism of the genus '' Leishmania'' that are responsible for the disease leishmaniasis. They are spread by sandflies of the genus ''Phlebotomus'' in the Old World, and of the genus ''Lutzomyia'' in the New World. At least 93 sandfly species are proven or probable vectors worldwide.WHO (2010) Annual report. Geneva Their primary hosts are vertebrates; ''Leishmania'' commonly infects hyraxes, canids, rodents, and humans. History Members of an ancient genus of the ''Leishmania'' parasite, ''Paleoleishmania'', have been detected in fossilized sand flies dating back to the early Cretaceous period. The first written reference to the conspicuous symptoms of cutaneous leishmaniasis surfaced in the Paleotropics within oriental texts dating back to the 7th century BC (allegedly transcribed from sources several hundred years older, between 1500 and 2000 BC). Due to its broad and persistent prevalence throughout antiquity as a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glycolipid
Glycolipids are lipids with a carbohydrate attached by a glycosidic (covalent) bond. Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response and in the connections that allow cells to connect to one another to form tissues. Glycolipids are found on the surface of all eukaryotic cell membranes, where they extend from the phospholipid bilayer into the extracellular environment. Structure The essential feature of a glycolipid is the presence of a monosaccharide or oligosaccharide bound to a lipid moiety. The most common lipids in cellular membranes are glycerolipids and sphingolipids, which have glycerol or a sphingosine backbones, respectively. Fatty acids are connected to this backbone, so that the lipid as a whole has a polar head and a non-polar tail. The lipid bilayer of the cell membrane consists of two layers of lipids, with the inner and outer surfaces of the membrane made up of the pol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glycoproteins
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. Secreted extracellular proteins are often glycosylated. In proteins that have segments extending extracellularly, the extracellular segments are also often glycosylated. Glycoproteins are also often important integral membrane proteins, where they play a role in cell–cell interactions. It is important to distinguish endoplasmic reticulum-based glycosylation of the secretory system from reversible cytosolic-nuclear glycosylation. Glycoproteins of the cytosol and nucleus can be modified through the reversible addition of a single GlcNAc residue that is considered reciprocal to phosphorylation and the functions of these are likely to be an additional regulatory mechanism that controls phosphorylation-based signalling. In contrast, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recombinant Protein
Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) that bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome. Recombinant DNA is the general name for a piece of DNA that has been created by combining at least two fragments from two different sources. Recombinant DNA is possible because DNA molecules from all organisms share the same chemical structure, and differ only in the nucleotide sequence within that identical overall structure. Recombinant DNA molecules are sometimes called chimeric DNA, because they can be made of material from two different species, like the mythical chimera. R-DNA technology uses palindromic sequences and leads to the production of sticky and blunt ends. The DNA sequences used in the construction of recombinant DNA molecules can originate from any species. For example, plant DNA may be joined to bacte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uzbekistan
Uzbekistan (, ; uz, Ozbekiston, italic=yes / , ; russian: Узбекистан), officially the Republic of Uzbekistan ( uz, Ozbekiston Respublikasi, italic=yes / ; russian: Республика Узбекистан), is a doubly landlocked country located in Central Asia. It is surrounded by five landlocked countries: Kazakhstan to the north; Kyrgyzstan to the northeast; Tajikistan to the southeast; Afghanistan to the south; and Turkmenistan to the southwest. Its capital and largest city is Tashkent. Uzbekistan is part of the Turkic world, as well as a member of the Organization of Turkic States. The Uzbek language is the majority-spoken language in Uzbekistan, while Russian is widely spoken and understood throughout the country. Tajik is also spoken as a minority language, predominantly in Samarkand and Bukhara. Islam is the predominant religion in Uzbekistan, most Uzbeks being Sunni Muslims. The first recorded settlers in what is now Uzbekistan were Eastern Iranian no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iran–Iraq War
The Iran–Iraq War was an armed conflict between Iran and Iraq that lasted from September 1980 to August 1988. It began with the Iraqi invasion of Iran and lasted for almost eight years, until the acceptance of United Nations Security Council Resolution 598 by both sides. Iraq's primary rationale for the attack against Iran cited the need to prevent Ruhollah Khomeini—who had spearheaded Iran's Islamic Revolution in 1979—from exporting the new Iranian ideology to Iraq; there were also fears among the Iraqi leadership of Saddam Hussein that Iran, a theocratic state with a population predominantly composed of Shia Muslims, would exploit sectarian tensions in Iraq by rallying Iraq's Shia majority against the Baʽathist government, which was officially secular and dominated by Sunni Muslims. Iraq also wished to replace Iran as the power player in the Persian Gulf, which was not seen as an achievable objective prior to the Islamic Revolution because of Pahlavi Iran's economi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saul Adler
Saul Adler FRS ( he, שאול אדלר; May 17, 1895 – January 25, 1966) was an Israeli expert on parasitology. Early life Adler was born in 1895 in Kerelits (Karelichy), then in the Russian Empire, now in Belarus. In 1900, he and his family moved to England and they settled in Leeds. He studied at University of Leeds and the Liverpool School of Tropical Medicine. One of his brothers was Solomon Adler, the economist. Career From 1917 until 1920, Adler served in the Royal Army Medical Corps, attaining the rank of captain, serving in the Middle East, where he developed his first taste into research into tropical medicine, which he commenced studying after his military service, initially in Liverpool. In 1921, Adler went to Sierra Leone to conduct research into Malaria. In 1924, Chaim Weizmann offered him a job in Jerusalem to develop the new Institute of Microbiology. Later that year, he emigrated to Mandate Palestine and started working in Hadassah Hospital, becoming dire ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccination Of Dogs
Vaccination of dogs is the practice of animal vaccination applied to dogs. Programs in this field have contributed both to the health of dogs and to the public health. In countries where routine rabies vaccination of dogs is practiced, for example, rabies in humans is reduced to a very rare event. Currently, there are geographically defined ''core vaccines'' and individually chosen ''non-core vaccine'' recommendations for dogs. A number of controversies surrounding adverse reactions to vaccines have resulted in authoritative bodies revising their guidelines as to the type, frequency, and methods/locations for dog vaccination. Recommended administration of vaccines In 2010 and 2011, revised guidelines addressed concerns about adverse vaccine reactions by altering the recommended frequency, type, methods, and locations for administration of core and non-core canine vaccines. General schedule Most vaccination protocols recommend a series of vaccines for puppies, with vaccine booste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Npj Vaccines
This is a list of journals published by Nature Research. These include the flagship ''Nature'' journal, the ''Nature Reviews'' series (which absorbed the former ''Nature Clinical Practice'' series in 2009), the ''npj'' series, '' Scientific Reports'' and many others. List A B C E G H I J L M N ;''Nature Reviews'' series ;''npj'' series The ''Nature Partner Journals'' series, abbreviated ''npj'', is a series of online-only, open access, journals. It was launched in April 2014 with three journals: ''npj Primary Care Respiratory Medicine'', ''npj Biofilms and Microbiomes'', and ''npj Schizophrenia''. Each journal in the series is published through a partnership between Springer Nature and a separate academic organization, foundation, or institution. O P S T References {{reflist External linksList of journalson Nature.com * Nature Research Nature Portfolio (formerly known as Nature Publishing Group and Nature Research) is a division of the int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CRISPR-Cas9
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering applications. Its main function is to cut DNA and thereby alter a cell's genome. The CRISPR-Cas9 genome editing technique was a significant contributor to the Nobel Prize in Chemistry in 2020 being awarded to Emmanuelle Charpentier and Jennifer Doudna. More technically, Cas9 is a dual RNA-guided DNA endonuclease enzyme associated with the Clustered Regularly Interspaced Short Palindromic Repeats ( CRISPR) adaptive immune system in ''Streptococcus pyogenes''. ''S. pyogenes'' utilizes CRISPR to memorize and Cas9 to later interrogate and cleave foreign DNA, such as invading bacteriophage DNA or plasmid DNA. Cas9 performs this interrogation by unwinding foreign DNA and checking for sites complementary to the 20 nucleotide sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunological Memory
Immunological memory is the ability of the immune system to quickly and specifically recognize an antigen that the body has previously encountered and initiate a corresponding immune response. Generally, these are secondary, tertiary and other subsequent immune responses to the same antigen. The adaptive immune system and antigen-specific receptor generation ( TCR, antibodies) are responsible for adaptive immune memory. After the inflammatory immune response to danger-associated antigen, some of the antigen-specific T cells and B cells persist in the body and become long-living memory T and B cells. After the second encounter with the same antigen, they recognize the antigen and mount a faster and more robust response. Immunological memory is the basis of vaccination.Hammarlund, Erika, et al. (2003). "Duration of antiviral immunity after smallpox vaccination." Nature medicine 9.9, 1131. Emerging resources show that even the innate immune system can initiate a more efficient immune ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
