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Ligand Binding Domain
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These receptors work with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often occurs in the presence of a ligand—a molecule that affects the receptor's behavior. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up- or down-regulation of gene expression. A unique property of nuclear receptors that differentiates them from other classes of receptors is their direct control of genomic DNA. Nuclear receptors play key roles in both embryonic development and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PPARg RXRa 3E00
Peroxisome proliferator- activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone reverse insulin resistance receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the ''PPARG'' gene. Tissue distribution PPARG is mainly present in adipose tissue, colon and macrophages. Two isoforms of PPARG are detected in the human and in the mouse: PPAR-γ1 (found in nearly all tissues except muscle) and PPAR-γ2 (mostly found in adipose tissue and the intestine). Gene expression This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genomic
Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of ''individual'' genes and their roles in inheritance, genomics aims at the collective characterization and quantification of ''all'' of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nematostella Vectensis
The starlet sea anemone (''Nematostella vectensis'') is a species of small sea anemone in the family Edwardsiidae native to the east coast of the United States, with introduced populations along the coast of southeast England and the west coast of the United States (class ''Anthozoa'', phylum ''Cnidaria'', a sister group of Bilateria). Populations have also been located in Nova Scotia, Canada. This sea anemone is found in the shallow brackish water of coastal lagoons and salt marshes where its slender column is usually buried in the mud and its tentacles exposed. Its genome has been sequenced and it is cultivated in the laboratory as a model organism, but the IUCN has listed it as being a "Vulnerable species" in the wild. Description The starlet sea anemone has a bulbous basal end and a contracting column that ranges in length from less than . There is a fairly distinct division between the scapus, the main part of the column, and the capitulum, the part just below the crown of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cnidarian
Cnidaria () is a phylum under kingdom Animalia containing over 11,000 species of aquatic animals found both in freshwater and marine environments, predominantly the latter. Their distinguishing feature is cnidocytes, specialized cells that they use mainly for capturing prey. Their bodies consist of mesoglea, a non-living jelly-like substance, sandwiched between two layers of epithelium that are mostly one cell thick. Cnidarians mostly have two basic body forms: swimming medusae and sessile polyps, both of which are radially symmetrical with mouths surrounded by tentacles that bear cnidocytes. Both forms have a single orifice and body cavity that are used for digestion and respiration. Many cnidarian species produce colonies that are single organisms composed of medusa-like or polyp-like zooids, or both (hence they are trimorphic). Cnidarians' activities are coordinated by a decentralized nerve net and simple receptors. Several free-swimming species of Cubozoa and Scyphozo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trichoplax Adhaerens
''Trichoplax adhaerens'' is one of the three named species in the phylum Placozoa. The others are ''Hoilungia hongkongensis'' and ''Polyplacotoma mediterranea''. The Placozoa is a basal group of multicellular animals (metazoa). ''Trichoplax'' are very flat organisms around a millimetre in diameter, lacking any organs or internal structures. They have two cellular layers: the top epitheloid layer is made of ciliated «cover cells» flattened toward the outside of the organism, and the bottom layer is made up of cylinder cells that possess cilia used in locomotion, and gland cells that lack cilia. Between these layers is the fibre syncytium, a liquid-filled cavity strutted open by star-like fibres. ''Trichoplax'' feed by absorbing food particles—mainly microbes—with their underside. They generally reproduce asexually, by dividing or budding, but can also reproduce sexually. Though ''Trichoplax'' has a small genome in comparison to other animals, nearly 87% of its 11,514 predi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Placozoa
The Placozoa are a basal form of marine free-living (non-parasitic) multicellular organism. They are the simplest in structure of all animals. Three genera have been found: the classical ''Trichoplax adhaerens'', ''Hoilungia hongkongensis'', and ''Polyplacotoma mediterranea'', where the last appears most basal. The last two have been found only since 2017. Although the Placozoa were first discovered in 1883 by the German zoologist Franz Eilhard Schulze (1840–1921) and since the 1970s more systematically analyzed by the German protozoologist Karl Gottlieb Grell (1912–1994), a common name does not yet exist for the taxon; the scientific name means "flat animals". Biology ''Trichoplax'' is a small, flattened, animal around across. An amorphous multi-celled body, analogous to a single-celled ''Amoeba'', it has no regular outline, although the lower surface is somewhat concave, and the upper surface is always flattened. The body consists of an outer layer of simple epithelium ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mnemiopsis Leidyi
''Mnemiopsis leidyi'', the warty comb jelly or sea walnut, is a species of tentaculate ctenophore (comb jelly). It is native to western Atlantic coastal waters, but has become established as an invasive species in European and western Asian regions. Three species have been named in the genus ''Mnemiopsis'', but they are now believed to be different ecological forms of a single species ''M. leidyi'' by most zoologists. Description and ecology ''Mnemiopsis'' have an oval-shaped and transparent lobed body, with four rows of ciliated combs that run along the body vertically and glow blue-green when disturbed. They have several feeding tentacles. Unlike cnidarians, ''Mnemiopsis'' does not sting. Their body comprises 97% water. They have a maximum body length of roughly and a diameter of . It is euryoecious, tolerating a wide range of salinity (2 to 38 psu), temperature (), and water quality. ''Mnemiopsis'' is a carnivore that consumes zooplankton including crustaceans, other comb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ctenophore
Ctenophora (; ctenophore ; ) comprise a phylum of marine invertebrates, commonly known as comb jellies, that inhabit sea waters worldwide. They are notable for the groups of cilia they use for swimming (commonly referred to as "combs"), and they are the largest animals to swim with the help of cilia. Depending on the species, adult ctenophores range from a few millimeters to in size. Only 100 to 150 species have been validated, and possibly another 25 have not been fully described and named. The textbook examples are cydippids with egg-shaped bodies and a pair of retractable tentacles fringed with tentilla ("little tentacles") that are covered with colloblasts, sticky cells that capture prey. Their bodies consist of a mass of jelly, with a layer two cells thick on the outside, and another lining the internal cavity. The phylum has a wide range of body forms, including the egg-shaped cydippids with retractable tentacles that capture prey, the flat generally combless platyct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amphimedon Queenslandica
''Amphimedon queenslandica'' (formerly known as ''Reniera'' sp.) is a sponge native to the Great Barrier Reef. Its genome has been sequenced. It has been the subject of various studies on the evolution of metazoan development. ''A. queenslandica'' was first discovered in 1998 on Heron Island Reef by Sally Leys when looking for sponges with larvae to study polarity, and was formally described by John Hooper and Rob van Soest in 2006. Like most sponges it has a biphasic life cycle, passing through a planktonic phase whilst a larva, but later becoming a benthic dweller. It is hermaphroditic, and reproduces via spermcast spawning, meaning it releases sperm into water but retains eggs, which are fertilised internally. The embryos develop in brood chambers until they reach a certain size, then disperse as parenchymella larvae. During this larval stage, they have a strong preference for darkness. The sponge is difficult or impossible to maintain in captivity. Genetics The genome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sponge
Sponges, the members of the phylum Porifera (; meaning 'pore bearer'), are a basal animal clade as a sister of the diploblasts. They are multicellular organisms that have bodies full of pores and channels allowing water to circulate through them, consisting of jelly-like mesohyl sandwiched between two thin layers of cells. Sponges have unspecialized cells that can transform into other types and that often migrate between the main cell layers and the mesohyl in the process. Sponges do not have nervous, digestive or circulatory systems. Instead, most rely on maintaining a constant water flow through their bodies to obtain food and oxygen and to remove wastes. Sponges were first to branch off the evolutionary tree from the last common ancestor of all animals, making them the sister group of all other animals. Etymology The term ''sponge'' derives from the Ancient Greek word ( 'sponge'). Overview Sponges are similar to other animals in that they are multicellular, he ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fungi
A fungus ( : fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, separately from the other eukaryotic kingdoms, which by one traditional classification include Plantae, Animalia, Protozoa, and Chromista. A characteristic that places fungi in a different kingdom from plants, bacteria, and some protists is chitin in their cell walls. Fungi, like animals, are heterotrophs; they acquire their food by absorbing dissolved molecules, typically by secreting digestive enzymes into their environment. Fungi do not photosynthesize. Growth is their means of mobility, except for spores (a few of which are flagellated), which may travel through the air or water. Fungi are the principal decomposers in ecological systems. These and other differences place fungi in a single group of related organisms, named the ''Eumycota'' (''t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Algae
Algae (; singular alga ) is an informal term for a large and diverse group of photosynthetic eukaryotic organisms. It is a polyphyletic grouping that includes species from multiple distinct clades. Included organisms range from unicellular microalgae, such as ''Chlorella,'' ''Prototheca'' and the diatoms, to multicellular forms, such as the giant kelp, a large brown alga which may grow up to in length. Most are aquatic and autotrophic (they generate food internally) and lack many of the distinct cell and tissue types, such as stomata, xylem and phloem that are found in land plants. The largest and most complex marine algae are called seaweeds, while the most complex freshwater forms are the ''Charophyta'', a division of green algae which includes, for example, ''Spirogyra'' and stoneworts. No definition of algae is generally accepted. One definition is that algae "have chlorophyll ''a'' as their primary photosynthetic pigment and lack a sterile covering of cells around thei ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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